2. Gene
  3. Magi2 - membrane associated guanylate kinase, WW and PDZ domain containing 2 Gene

Magi2 - membrane associated guanylate kinase, WW and PDZ domain containing 2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: AIP-1; S-SCAM; Acvrip1; Acvrinp1

基因 ID: 113970 | 基因类型: protein coding

关于 Magi2

功能概要

Enables Kinesin binding activity. A structural constituent of postsynaptic density. Involved in several processes, including nerve growth factor signaling pathway; regulation of neurotransmitter receptor localization to postsynaptic specialization membrane; and regulation of synaptic membrane adhesion. Located in several cellular components, including late endosome; perinuclear region of cytoplasm; and slit diaphragm. Part of protein-containing complex. Is active in GABA-ergic synapse; glutamatergic synapse; and postsynaptic density. Is extrinsic component of postsynaptic membrane. Human ortholog(s) of this gene implicated in nephrotic syndrome type 15. Orthologous to human MAGI2 (membrane associated guanylate kinase, WW and PDZ domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]

Magi2 基因产物(1)

mRNA Protein Name
NM_053621.2 NP_446073.2 membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables kinesin binding IPI
IPI: 通过物理相互作用推断
12097473 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
9694864 RGD
enables protein-containing complex binding IDA
IDA: 通过直接分析推断
10644767 RGD
enables protein-containing complex binding IPI
IPI: 通过物理相互作用推断
15331416 RGD
enables structural constituent of postsynaptic density IDA
IDA: 通过直接分析推断
22593065 RGD
enables structural constituent of postsynaptic density IMP
IMP: 通过突变表型推断
22593065 RGD
enables structural constituent of postsynaptic specialization IDA
IDA: 通过直接分析推断
23751499 RGD
enables structural constituent of postsynaptic specialization IMP
IMP: 通过突变表型推断
23751499 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to nerve growth factor stimulus IDA
IDA: 通过直接分析推断
17724123 RGD
involved in negative regulation of cell migration IDA
IDA: 通过直接分析推断
17880912 RGD
involved in negative regulation of cell population proliferation IDA
IDA: 通过直接分析推断
17880912 RGD
involved in nerve growth factor signaling pathway IDA
IDA: 通过直接分析推断
17724123 RGD
involved in podocyte development IEP
IEP: 通过表达模式推断
15994232 RGD
involved in positive regulation of neuron projection development IMP
IMP: 通过突变表型推断
17724123 RGD
involved in receptor clustering IDA
IDA: 通过直接分析推断
10644767 RGD
involved in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane IDA
IDA: 通过直接分析推断
22593065 RGD
involved in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane IMP
IMP: 通过突变表型推断
22593065 RGD
involved in regulation of synaptic membrane adhesion IDA
IDA: 通过直接分析推断
23751499 RGD
involved in regulation of synaptic membrane adhesion IMP
IMP: 通过突变表型推断
23751499 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in GABA-ergic synapse IDA
IDA: 通过直接分析推断
17059560 RGD
is active in GABA-ergic synapse IMP
IMP: 通过突变表型推断
23751499 RGD
located in cytoplasm IDA
IDA: 通过直接分析推断
17724123 RGD
located in dendrite IDA
IDA: 通过直接分析推断
10548487 RGD
is active in extrinsic component of postsynaptic membrane IDA
IDA: 通过直接分析推断
17059560 RGD
is active in glutamatergic synapse IDA
IDA: 通过直接分析推断
9694864 RGD
is active in glutamatergic synapse IMP
IMP: 通过突变表型推断
22593065 RGD
located in late endosome IDA
IDA: 通过直接分析推断
17724123 RGD
located in perinuclear region of cytoplasm IDA
IDA: 通过直接分析推断
12589829 RGD
is active in postsynaptic density IDA
IDA: 通过直接分析推断
9694864 RGD
located in postsynaptic density IDA
IDA: 通过直接分析推断
12589829 RGD
part of protein-containing complex IDA
IDA: 通过直接分析推断
15331416 RGD
located in slit diaphragm IDA
IDA: 通过直接分析推断
15994232 RGD
located in synapse IDA
IDA: 通过直接分析推断
10548487 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2

activin receptor interacting protein 1

atrophin-1-interacting protein 1

membrane-associated guanylate kinase inverted 2

synaptic-scaffolding molecule

Magi2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Cross Magi2 O88382 CRHR1 Homo sapiens P34998
Anti Tag CoIP
26352593
Cross Magi2 O88382 DDN Homo sapiens O94850
Pull Down
16751601
Cross Magi2 O88382 PTEN Homo sapiens P60484
Anti Tag CoIP
15951562
Cross Magi2 O88382 PTEN Homo sapiens P60484
Pull Down
15951562
Intra Magi2 O88382 Tamalin Rattus norvegicus Q8R4T5
Anti Bait CoIP
12586822
Intra Magi2 O88382 Tamalin Rattus norvegicus Q8R4T5
Pull Down
12586822
Intra Magi2 O88382 Dlgap1 Rattus norvegicus P97836
Y2H
9694864
Intra Magi2 O88382 Dlgap1 Rattus norvegicus P97836
Filter Binding
9694864
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS07982 MAGI2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Magi2 NCBI NCBI:9863
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