2. Gene
  3. SIGLEC11 - sialic acid binding Ig like lectin 11 Gene

SIGLEC11 - sialic acid binding Ig like lectin 11 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：唾液酸结合 Ig 样凝集素 11

种属: Homo sapiens

基因 ID: 114132 | 基因类型: protein coding

关于 SIGLEC11

Cytogenetic location: 19q13.33 Genomic coordinates (GRCh38): 19:49,948,985-49,961,172 (from NCBI)

This gene has 3 transcripts (splice variants), 133 orthologues and 16 paralogues. Biased expression in ovary (RPKM 40.7), spleen (RPKM 13.8) and 1 other tissue.

功能概要

该基因编码唾液酸结合免疫球蛋白样凝集素家族的成员。这些细胞表面凝集素的特征在于免疫球蛋白 (Ig) 样结构域中的结构基序和第一个 Ig V 组结构域中的唾液酸识别位点。该家族成员介导抗炎和免疫抑制信号。已发现该基因编码不同异构体的多个转录变体。[RefSeq 提供，2011 年 10 月]

This gene encodes a member of the sialic acid-binding immunoglobulin-like lectin family. These cell surface lectins are characterized by structural motifs in the immunoglobulin (Ig)-like domains and sialic acid recognition sites in the first Ig V set domain. This family member mediates anti-inflammatory and immunosuppressive signaling. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

SIGLEC11 基因产物(2)

mRNA Protein Name
NM_001135163.1 NP_001128635.1 sialic acid-binding Ig-like lectin 11 isoform 2 precursor
NM_052884.3 NP_443116.2 sialic acid-binding Ig-like lectin 11 isoform 1 precursor
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables phosphatase binding IPI
IPI: 通过物理相互作用推断
11986327 GOA
enables sialic acid binding IDA
IDA: 通过直接分析推断
11986327 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SIGLEC11 蛋白结构

V-set

V-set: Immunoglobulin V-set domain (37 - 136)

C2-set_2

C2-set_2: CD80-like C2-set immunoglobulin domain (160 - 236)

I-set

I-set: Immunoglobulin I-set domain (275 - 351)

ig

ig: Immunoglobulin domain (384 - 438)

  • 0
  • 200
  • 400
  • 600
  • 698 a.a.
蛋白主名 其他名称

sialic acid-binding Ig-like lectin 11

siglec-11

重组 SIGLEC11 蛋白

目录号 产品名 蛋白编号 纯度
HY-P79127 Siglec-11 Protein, Human (E84A, K145Q, CHO, hFc) AAK72907 (N17-H543, E84A, K145Q) ≥95%

关联疾病

疾病名称 别名
Alzheimer Disease 2

AD2

Alzheimer Disease Associated With Apoe4

Alzheimer'S Disease 2

Alzheimer Disease-2

Alzheimer Disease 2, Late-Onset

Alzheimer Disease 2, Late Onset

Late-Onset Alzheimer Disease

Alzheimer Disease, Type 2

Alzheimer Disease, Late Onset
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS12899 SIGLEC11 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus SIGLEC11 MGD MGI:2443630
Others SIGLEC11 NCBI
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