2. Gene
  3. SLITRK1 - SLIT and NTRK like family member 1 Gene

SLITRK1 - SLIT and NTRK like family member 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：SLIT 和 NTRK 样家族成员 1

种属: Homo sapiens

同用名: TTM; LRRC12

基因 ID: 114798 | 基因类型: protein coding

关于 SLITRK1

Cytogenetic location: 13q31.1 Genomic coordinates (GRCh38): 13:83,877,205-83,882,474 (from NCBI)

This gene has 2 transcripts (splice variants), 187 orthologues, 25 paralogues and is associated with 3 phenotypes. Restricted expression toward brain (RPKM 10.6).

功能概要

该基因编码 SLITRK 蛋白家族的一个成员。该家族的成员是完整的膜蛋白，其特征在于两个 N 末端富含亮氨酸重复序列 (LRR) 结构域和一个与 trk 神经营养蛋白受体具有同源性的 C 末端区域。然而，该基因编码的蛋白质缺乏与神经营养蛋白受体同源的区域。这种蛋白质被认为与神经突生长有关。该基因的突变可能与图雷特综合征有关。可变剪接导致多个转录本变体。[RefSeq 提供，2013 年 7 月]

This gene encodes a member of the SLITRK protein family. Members of this family are integral membrane proteins that are characterized by two N-terminal leucine-rich repeat (LRR) domains and a C-terminal region that shares homology with trk neurotrophin receptors. However, the protein encoded by this gene lacks the region of homology to neurotrophin receptors. This protein is thought to be involved in neurite outgrowth. Mutations in this gene may be associated with Tourette syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

SLITRK1 基因产物(2)

mRNA Protein Name
NM_001281503.2 NP_001268432.1 SLIT and NTRK-like protein 1 precursor
NM_052910.2 NP_443142.1 SLIT and NTRK-like protein 1 precursor

SLITRK1 蛋白结构

LRR_8

LRR_8: Leucine rich repeat (132 - 189)

LRR_1

LRR_1: Leucine Rich Repeat (400 - 422)

LRR_8

LRR_8: Leucine rich repeat (425 - 483)

  • 0
  • 200
  • 400
  • 600
  • 696 a.a.
蛋白主名 其他名称

SLIT and NTRK-like protein 1

leucine-rich repeat-containing protein 12

重组 SLITRK1 蛋白

目录号 产品名 蛋白编号 纯度
HY-P76077 SLITRK1 Protein, Human (HEK293, His-Fc) Q96PX8 (M1-S616) ≥95%
HY-P76078 SLITRK1 Protein, Human (HEK293, His) Q96PX8 (N18-S616) ≥95%

关联疾病

疾病名称 别名
Trichotillomania

TTM

Hair-Pulling Syndrome

Compulsive Hair Plucking

Hair Pulling Disorder
Gilles De La Tourette Syndrome

Tourette Syndrome

Tourette Disorder

GTS

Ts

Gilles De La Tourette'S Syndrome

Motor-Verbal Tic Disorder

Guinon'S Disease

Psychogenic Tics

Tourette'S Syndrome

Chronic Motor And Vocal Tic Disorder

Td

Tourette'S Disease

Combined Vocal And Multiple Motor Tic Disorder [De La Tourette]

Combined Vocal And Multiple Motor Tic Disorder

Tic De La Tourette
Obsessive-Compulsive Disorder

OCD

Obsessive-Compulsive Disorder, Susceptibility To

Anancastic Neurosis

Obsessive Compulsive Disorder

Anankastic Neurosis

Obsessive-Compulsive Neurosis

Obsessive Compulsive Behavior
Chronic Tic Disorder

Chronic Motor Or Vocal Tic Disorder

Tic Disorders

Tic Disorder

Tic Disorder Nos

Tic Nos

Tic Spasm Nos
Transient Tic Disorder
Tic Disorder

Tics

Behavioral Tic
Color Agnosia
Deafness, Autosomal Dominant 33

DFNA33

Autosomal Dominant Nonsyndromic Deafness 33

Autosomal Dominant Deafness 33
Trichothiodystrophy 5, Nonphotosensitive

TTD5

Nonphotosensitive Trichothiodystrophy 5

Trichothiodystrophy 5, Non-Photosensitive
Impulse Control Disorder

Disruptive, Impulse Control, And Conduct Disorders
Abcd Syndrome

ABCDS

Albinism, Black Lock, Cell Migration Disorder Of The Neurocytes Of The Gut, And Deafness

Albinism, Black Lock, Cell Migration Disorder Of The Neurocytes Of The Gut And Deafness
Echolalia
Stereotypic Movement Disorder

Stereotypy Habit Disorder

Stereotyped Repetitive Movements

Stereotyped Disorder

Stereotypes Nos

Stereotype Habit Disorder
Attention Deficit-Hyperactivity Disorder

Attention Deficit Hyperactivity Disorder

ADHD

Attention Deficit Disorder

Attention Deficit-Hyperactivity Disorder, Susceptibility To

Attention Deficit Disorder With Hyperactivity

Hyperkinetic Disorder

Hyperactivity Of Childhood

Attention-Deficit/Hyperactivity Disorder

Add

Addh

Attention Deficit

Attention Deficit Disorder Of Childhood With Hyperactivity

Attention Deficit Disorder With Hyperactivity Syndrome

Hyperkinetic Syndrome

Attention-Deficit Hyperactivity Disorder

Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type

Disturbance Of Activity And Attention

Disorder Of Activity And Attention

Adhd - [Attention Deficit Hyperactivity Disorder]

Hyperkinetic Disorders

Disorder Of Activity And Attention With Hyperkinesia

Attention Deficit Syndrome With Hyperactivity
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS13373 SLITRK1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus SLITRK1 VGNC VGNC:65454
Rattus norvegicus SLITRK1 RGD RGD:1308858
Mus musculus SLITRK1 MGD MGI:2679446
Bos taurus SLITRK1 VGNC VGNC:34962
Canis familiaris SLITRK1 VGNC VGNC:46506
Macaca mulatta SLITRK1 VGNC VGNC:77744
Others SLITRK1 NCBI
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