SLITRK1 - SLIT and NTRK like family member 1 Gene

中文名称：SLIT 和 NTRK 样家族成员 1

种属: Homo sapiens

同用名: TTM; LRRC12

基因 ID: 114798 | 基因类型: protein coding

关于 SLITRK1

Cytogenetic location: 13q31.1 Genomic coordinates (GRCh38): 13:83,877,205-83,882,474 (from NCBI)

This gene has 2 transcripts (splice variants), 187 orthologues, 25 paralogues and is associated with 3 phenotypes. Restricted expression toward brain (RPKM 10.6).

功能概要

该基因编码 SLITRK 蛋白家族的一个成员。该家族的成员是完整的膜蛋白，其特征在于两个 N 末端富含亮氨酸重复序列 (LRR) 结构域和一个与 Trk 神经营养蛋白受体具有同源性的 C 末端区域。然而，该基因编码的蛋白质缺乏与神经营养蛋白受体同源的区域。这种蛋白质被认为与神经突生长有关。该基因的突变可能与图雷特综合征有关。可变剪接导致多个转录本变体。[RefSeq 提供，2013 年 7 月]

This gene encodes a member of the SLITRK protein family. Members of this family are integral membrane proteins that are characterized by two N-terminal leucine-rich repeat (LRR) domains and a C-terminal region that shares homology with Trk neurotrophin receptors. However, the protein encoded by this gene lacks the region of homology to neurotrophin receptors. This protein is thought to be involved in neurite outgrowth. Mutations in this gene may be associated with Tourette syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

SLITRK1 基因产物(2)

mRNA	Protein	Name
NM_001281503.2	NP_001268432.1	SLIT and NTRK-like protein 1 precursor
NM_052910.2	NP_443142.1	SLIT and NTRK-like protein 1 precursor

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	19640509	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in positive regulation of axonogenesis	IMP IMP: 通过突变表型推断	23990902	GOA
involved in regulation of presynapse assembly	IDA IDA: 通过直接分析推断	23345436	GOA
involved in regulation of presynapse assembly	IMP IMP: 通过突变表型推断	23345436	GOA
involved in synapse assembly	IMP IMP: 通过突变表型推断	27273464	GOA
involved in synaptic membrane adhesion	IDA IDA: 通过直接分析推断	23345436	GOA
involved in synaptic membrane adhesion	IMP IMP: 通过突变表型推断	23345436	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
is active in GABA-ergic synapse	IDA IDA: 通过直接分析推断	23345436	GOA
is active in GABA-ergic synapse	IMP IMP: 通过突变表型推断	23345436	GOA
is active in glutamatergic synapse	IDA IDA: 通过直接分析推断	23345436	GOA
is active in glutamatergic synapse	IMP IMP: 通过突变表型推断	23345436	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SLITRK1 蛋白结构

LRR_8

LRR_1

LRR_8

0
200
400
600
696 a.a.

蛋白主名

其他名称

SLIT and NTRK-like protein 1

leucine-rich repeat-containing protein 12

SLITRK1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	SLITRK1	Q96PX8	UBQLN2	Homo sapiens	Q9UHD9	Y2H Array	32296183
种属内	SLITRK1	Q96PX8	UBQLN2	Homo sapiens	Q9UHD9	Validated Y2H	32296183
种属内	SLITRK1	Q96PX8	UBQLN2	Homo sapiens	Q9UHD9	Y2H Prey Pooling	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 SLITRK1 蛋白

目录号	产品名	蛋白编号	纯度
HY-P76077	SLITRK1 Protein, Human (HEK293, His-Fc)	Q96PX8 (N18-S616)	≥95%
HY-P76078	SLITRK1 Protein, Human (HEK293, His)	Q96PX8 (N18-S616)	≥95%

关联疾病

疾病名称

别名

Trichotillomania

TTM	Hair-Pulling Syndrome
Compulsive Hair Plucking	Hair Pulling Disorder

Gilles De La Tourette Syndrome

Tourette Syndrome	Tourette Disorder
GTS	Ts
Gilles De La Tourette'S Syndrome	Motor-Verbal Tic Disorder
Guinon'S Disease	Psychogenic Tics
Tourette'S Syndrome	Chronic Motor And Vocal Tic Disorder
Td	Tourette'S Disease
Combined Vocal And Multiple Motor Tic Disorder [De La Tourette]	Combined Vocal And Multiple Motor Tic Disorder
Tic De La Tourette

Obsessive-Compulsive Disorder

OCD	Obsessive-Compulsive Disorder, Susceptibility To
Anancastic Neurosis	Obsessive Compulsive Disorder
Anankastic Neurosis	Obsessive-Compulsive Neurosis
Obsessive Compulsive Behavior

Chronic Tic Disorder

Chronic Motor Or Vocal Tic Disorder	Tic Disorders
Tic Disorder	Tic Disorder Nos
Tic Nos	Tic Spasm Nos

Transient Tic Disorder

Tic Disorder

Tics	Behavioral Tic

Color Agnosia

Deafness, Autosomal Dominant 33

DFNA33	Autosomal Dominant Nonsyndromic Deafness 33
Autosomal Dominant Deafness 33

Trichothiodystrophy 5, Nonphotosensitive

TTD5	Nonphotosensitive Trichothiodystrophy 5
Trichothiodystrophy 5, Non-Photosensitive

Impulse Control Disorder

Disruptive, Impulse Control, And Conduct Disorders

Abcd Syndrome

ABCDS	Albinism, Black Lock, Cell Migration Disorder Of The Neurocytes Of The Gut, And Deafness
Albinism, Black Lock, Cell Migration Disorder Of The Neurocytes Of The Gut And Deafness

Echolalia

Stereotypic Movement Disorder

Stereotypy Habit Disorder	Stereotyped Repetitive Movements
Stereotyped Disorder	Stereotypes Nos
Stereotype Habit Disorder

Attention Deficit-Hyperactivity Disorder

Attention Deficit Hyperactivity Disorder	ADHD
Attention Deficit Disorder	Attention Deficit-Hyperactivity Disorder, Susceptibility To
Attention Deficit Disorder With Hyperactivity	Hyperkinetic Disorder
Hyperactivity Of Childhood	Attention-Deficit/Hyperactivity Disorder
Add	Addh
Attention Deficit	Attention Deficit Disorder Of Childhood With Hyperactivity
Attention Deficit Disorder With Hyperactivity Syndrome	Hyperkinetic Syndrome
Attention-Deficit Hyperactivity Disorder	Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type
Disturbance Of Activity And Attention	Disorder Of Activity And Attention
Adhd - [Attention Deficit Hyperactivity Disorder]	Hyperkinetic Disorders
Disorder Of Activity And Attention With Hyperkinesia	Attention Deficit Syndrome With Hyperactivity

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS13373	SLITRK1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Felis catus	SLITRK1	VGNC	VGNC:65454
Rattus norvegicus	SLITRK1	RGD	RGD:1308858
Mus musculus	SLITRK1	MGD	MGI:2679446
Bos taurus	SLITRK1	VGNC	VGNC:34962
Canis familiaris	SLITRK1	VGNC	VGNC:46506
Macaca mulatta	SLITRK1	VGNC	VGNC:77744
Others	SLITRK1	NCBI

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上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

SLITRK1 - SLIT and NTRK like family member 1 Gene

关于 SLITRK1

功能概要

SLITRK1 基因产物(2)

SLITRK1 蛋白结构

SLITRK1 蛋白互作信息

重组 SLITRK1 蛋白

关联疾病

直系同源

热门区域

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SLITRK1 - SLIT and NTRK like family member 1 Gene

关于 SLITRK1

功能概要

SLITRK1 基因产物(2)

SLITRK1 蛋白结构

SLITRK1 蛋白互作信息

重组 SLITRK1 蛋白

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z