2. Gene
  3. NOSTRIN - nitric oxide synthase trafficking Gene

NOSTRIN - nitric oxide synthase trafficking Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：一氧化氮合酶运输

种属: Homo sapiens

同用名: DaIP2

基因 ID: 115677 | 基因类型: protein coding

关于 NOSTRIN

Cytogenetic location: 2q24.3 Genomic coordinates (GRCh38): 2:168,786,539-168,865,514 (from NCBI)

This gene has 13 transcripts (splice variants), 1 gene allele, 176 orthologues and 3 paralogues. Ubiquitous expression in fat (RPKM 8.2), lung (RPKM 6.6) and 24 other tissues.

功能概要

一氧化氮 (NO) 是神经传递、炎症反应和血管稳态等生物过程中的有效介质。 NOSTRIN 结合负责 NO 产生的酶，内皮 NO 合酶 (ENOS；MIM 163729) ，并触发 eNOS 从质膜转移到囊泡样亚细胞结构，从而减弱 eNOS 依赖性 NO 的产生。[OMIM 提供，4 月 2004]

Nitric oxide (NO) is a potent mediator in biologic processes such as neurotransmission, inflammatory response, and vascular homeostasis. NOSTRIN binds the Enzyme responsible for NO production, endothelial NO Synthase (ENOS; MIM 163729), and triggers the translocation of eNOS from the plasma membrane to vesicle-like subcellular structures, thereby attenuating ENOS-dependent NO production.[supplied by OMIM, Apr 2004]

NOSTRIN 基因产物(4)

mRNA Protein Name
NM_001039724.4 NP_001034813.2 nostrin isoform 2
NM_001171631.2 NP_001165102.1 nostrin isoform 4
NM_001171632.2 NP_001165103.1 nostrin isoform 3
NM_052946.4 NP_443178.2 nostrin isoform 1
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
12446846 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

NOSTRIN 蛋白结构

FCH

FCH: Fes/CIP4, and EFC/F-BAR homology domain (14 - 92)

SH3_1

SH3_1: SH3 domain (444 - 489)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 506 a.a.
蛋白主名 其他名称

nostrin

BM247 homolog

NOSTRIN 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra NOSTRIN Q8IVI9 FGFR1 Homo sapiens P11362
Y2H
22751148
Intra NOSTRIN Q8IVI9 FGFR1 Homo sapiens P11362
Pull Down
22751148
Intra NOSTRIN Q8IVI9 NOS3 Homo sapiens P29474
Anti Tag CoIP
16234328
Intra NOSTRIN Q8IVI9 NOS3 Homo sapiens P29474
Confocal
12446846
Intra NOSTRIN Q8IVI9 NOS3 Homo sapiens P29474
Pull Down
16234328
Intra NOSTRIN Q8IVI9 NOS3 Homo sapiens P29474
Y2H
12446846
Intra NOSTRIN Q8IVI9 NOS3 Homo sapiens P29474
Anti Bait CoIP
12446846
Intra NOSTRIN Q8IVI9 DNM1 Homo sapiens Q05193
Pull Down
16234328
Cross NOSTRIN Q8IVI9 Wasl Rattus norvegicus O08816
Pull Down
16234328
Cross NOSTRIN Q8IVI9 Wasl Rattus norvegicus O08816
Anti Tag CoIP
16234328
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Eclampsia

Eclampsia In Puerperium

Postpartum Eclampsia

Eclampsia, Postpartum

Puerperal Eclampsia
Pre-Eclampsia

Preeclampsia

Gestational Hypertension

Hypertension Induced By Pregnancy

Pre-Eclamptic Toxaemia

Pregnancy Associated Hypertension

Proteinuric Hypertension Of Pregnancy

Hypertension, Pregnancy-Induced, Susceptibility To

Preeclampsia/Eclampsia

Pregnancy Toxemia

Toxaemia Of Pregnancy

Gestational Proteinuric Hypertension

Pregnancy-Induced Hypertension

Toxemia Of Pregnancy

Preeclampsia, Susceptibility To

Transient Hypertension Of Pregnancy

Gestational [Pregnancy-Induced] Hypertension Without Significant Proteinuria

Gestational Hypertension Nos

Mild Proteinuric Hypertension Of Pregnancy

Pih - [Pregnancy-Induced Hypertension]

Pregnancy-Induced Hypertension Nos

Gestational [Pregnancy-Induced] Hypertension With Significant Proteinuria

Pe - [Pre-Eclampsia]

Pre-Eclampsia Nos

Pre-Eclamptic Nos

Pregnancy Pre-Eclampsia

Puerperal Pre-Eclampsia

Pre-Eclampsia Toxaemia

Toxaemia In Pregnancy

Pet - [Pre-Eclamptic Toxaemia]

Maternal Toxaemia
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS09444 NOSTRIN Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus NOSTRIN MGD MGI:3606242
Canis familiaris NOSTRIN VGNC VGNC:43897
Rattus norvegicus NOSTRIN RGD RGD:727920
Macaca mulatta NOSTRIN VGNC VGNC:75219
Bos taurus NOSTRIN VGNC VGNC:32176
Felis catus NOSTRIN VGNC VGNC:63862
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