2. Gene
  3. DHRS1 - dehydrogenase/reductase 1 Gene

DHRS1 - dehydrogenase/reductase 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：脱氢酶/还原酶 1

种属: Homo sapiens

同用名: SDR19C1

基因 ID: 115817 | 基因类型: protein coding

关于 DHRS1

Cytogenetic location: 14q12 Genomic coordinates (GRCh38): 14:24,290,598-24,299,780 (from NCBI)

This gene has 11 transcripts (splice variants), 1 gene allele, 197 orthologues and 13 paralogues. Ubiquitous expression in liver (RPKM 39.6), esophagus (RPKM 38.5) and 24 other tissues.

功能概要

该基因编码短链脱氢酶/还原酶 (SDR) 家族的成员。编码的酶包含一个保守的催化结构域，可能起氧化还原酶的作用。已经鉴定出编码相同蛋白质的多个可变剪接变体。[RefSeq 提供，2008 年 11 月]

This gene encodes a member of the short-chain dehydrogenases/reductases (SDR) family. The encoded Enzyme contains a conserved catalytic domain and likely functions as an oxidoreductase. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Nov 2008]

DHRS1 基因产物(2)

mRNA Protein Name
NM_001136050.3 NP_001129522.1 dehydrogenase/reductase SDR family member 1
NM_138452.3 NP_612461.1 dehydrogenase/reductase SDR family member 1
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables carbonyl reductase (NADPH) activity IDA
IDA: 通过直接分析推断
30031147 GOA
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IDA
IDA: 通过直接分析推断
30031147 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
16189514 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

DHRS1 蛋白结构

adh_short

adh_short: short chain dehydrogenase (9 - 181)

  • 0
  • 100
  • 200
  • 313 a.a.
蛋白主名 其他名称

dehydrogenase/reductase SDR family member 1

dehydrogenase/reductase (SDR family) member 1

DHRS1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra DHRS1 Q96LJ7 KRTAP10-8 Homo sapiens P60410
Y2H Array
32296183
Intra DHRS1 Q96LJ7 KRTAP10-8 Homo sapiens P60410
Validated Y2H
25416956
Intra DHRS1 Q96LJ7 KRTAP10-8 Homo sapiens P60410
Y2H Prey Pooling
32296183
Intra DHRS1 Q96LJ7 KRTAP10-9 Homo sapiens P60411
Y2H Prey Pooling
32296183
Intra DHRS1 Q96LJ7 KRTAP10-9 Homo sapiens P60411
Y2H Array
32296183
Intra DHRS1 Q96LJ7 KRTAP12-2 Homo sapiens P59991
Y2H Array
32296183
Intra DHRS1 Q96LJ7 KRTAP12-2 Homo sapiens P59991
Y2H Prey Pooling
32296183
Intra DHRS1 Q96LJ7 KRTAP12-1 Homo sapiens P59990
Y2H Prey Pooling
32296183
Intra DHRS1 Q96LJ7 KRTAP12-1 Homo sapiens P59990
Y2H Array
32296183
Intra DHRS1 Q96LJ7 KRTAP4-11 Homo sapiens Q9BYQ6
Y2H Prey Pooling
32296183
Intra DHRS1 Q96LJ7 KRTAP4-11 Homo sapiens Q9BYQ6
Validated Y2H
32296183
Intra DHRS1 Q96LJ7 KRTAP4-11 Homo sapiens Q9BYQ6
Y2H Array
32296183
Intra DHRS1 Q96LJ7 KRT34 Homo sapiens O76011
Y2H Prey Pooling
32296183
Intra DHRS1 Q96LJ7 KRT34 Homo sapiens O76011
Y2H Array
32296183
Intra DHRS1 Q96LJ7 KRTAP11-1 Homo sapiens Q8IUC1
Y2H Array
32296183
Intra DHRS1 Q96LJ7 KRTAP11-1 Homo sapiens Q8IUC1
Y2H Prey Pooling
32296183
Intra DHRS1 Q96LJ7 LCE2B Homo sapiens O14633
Y2H Array
32296183
Intra DHRS1 Q96LJ7 LCE2B Homo sapiens O14633
Y2H Prey Pooling
32296183
Intra DHRS1 Q96LJ7 MTUS2 Homo sapiens Q5JR59-3
Y2H Array
32296183
Intra DHRS1 Q96LJ7 MTUS2 Homo sapiens Q5JR59-3
Y2H Prey Pooling
32296183
Intra DHRS1 Q96LJ7 KRTAP1-3 Homo sapiens Q8IUG1
Y2H Prey Pooling
32296183
Intra DHRS1 Q96LJ7 KRTAP1-3 Homo sapiens Q8IUG1
Y2H Array
32296183
Intra DHRS1 Q96LJ7 KRTAP12-3 Homo sapiens P60328
Y2H Prey Pooling
32296183
Intra DHRS1 Q96LJ7 KRTAP12-3 Homo sapiens P60328
Y2H Array
32296183
Intra DHRS1 Q96LJ7 KRTAP5-2 Homo sapiens Q701N4
Y2H Array
32296183
Intra DHRS1 Q96LJ7 KRTAP5-2 Homo sapiens Q701N4
Y2H Prey Pooling
32296183
Intra DHRS1 Q96LJ7 KRTAP9-8 Homo sapiens Q9BYQ0
Validated Y2H
32296183
Intra DHRS1 Q96LJ7 KRTAP9-8 Homo sapiens Q9BYQ0
Y2H Prey Pooling
32296183
Intra DHRS1 Q96LJ7 KRTAP9-8 Homo sapiens Q9BYQ0
Y2H Array
32296183
Intra DHRS1 Q96LJ7 KRTAP1-1 Homo sapiens Q07627
Y2H Array
32296183
Intra DHRS1 Q96LJ7 KRTAP1-1 Homo sapiens Q07627
Y2H Prey Pooling
32296183
Intra DHRS1 Q96LJ7 KRTAP6-2 Homo sapiens Q3LI66
Y2H Array
32296183
Intra DHRS1 Q96LJ7 KRTAP6-2 Homo sapiens Q3LI66
Y2H Prey Pooling
32296183
Intra DHRS1 Q96LJ7 KRTAP5-1 Homo sapiens Q6L8H4
Y2H Prey Pooling
32296183
Intra DHRS1 Q96LJ7 KRTAP5-1 Homo sapiens Q6L8H4
Y2H Array
32296183
Intra DHRS1 Q96LJ7 LAMP2 Homo sapiens P13473-2
Y2H Pooling
32814053
Intra DHRS1 Q96LJ7 LAMP2 Homo sapiens P13473-2
Validated Y2H
32814053
Intra DHRS1 Q96LJ7 LAMP2 Homo sapiens P13473-2
Y2H Array
32814053
Intra DHRS1 Q96LJ7 NOTCH2NLC Homo sapiens P0DPK4
Y2H Array
32296183
Intra DHRS1 Q96LJ7 NOTCH2NLC Homo sapiens P0DPK4
Y2H Prey Pooling
32296183
Intra DHRS1 Q96LJ7 KRTAP6-3 Homo sapiens Q3LI67
Y2H Prey Pooling
32296183
Intra DHRS1 Q96LJ7 KRTAP6-3 Homo sapiens Q3LI67
Y2H Array
32296183
Intra DHRS1 Q96LJ7 SH3GLB1 Homo sapiens Q9Y371
Validated Y2H
32814053
Intra DHRS1 Q96LJ7 SH3GLB1 Homo sapiens Q9Y371
Y2H Pooling
32814053
Intra DHRS1 Q96LJ7 SH3GLB1 Homo sapiens Q9Y371
Y2H Array
32814053
Intra DHRS1 Q96LJ7 LHX4 Homo sapiens Q969G2
Y2H Prey Pooling
32296183
Intra DHRS1 Q96LJ7 LHX4 Homo sapiens Q969G2
Y2H Array
32296183
Intra DHRS1 Q96LJ7 KRTAP4-1 Homo sapiens Q9BYQ7
Y2H Array
32296183
Intra DHRS1 Q96LJ7 KRTAP4-1 Homo sapiens Q9BYQ7
Y2H Prey Pooling
32296183
Intra DHRS1 Q96LJ7 KRTAP5-9 Homo sapiens P26371
Y2H Prey Pooling
25416956
Intra DHRS1 Q96LJ7 DIABLO Homo sapiens Q9NR28
Validated Y2H
32296183
Intra DHRS1 Q96LJ7 MDFI Homo sapiens Q99750
Y2H Prey Pooling
32296183
Intra DHRS1 Q96LJ7 MDFI Homo sapiens Q99750
Validated Y2H
32296183
Intra DHRS1 Q96LJ7 MDFI Homo sapiens Q99750
Y2H Array
32296183
Intra DHRS1 Q96LJ7 KRTAP3-2 Homo sapiens Q9BYR7
Y2H Prey Pooling
25416956
Intra DHRS1 Q96LJ7 NOTCH2NLA Homo sapiens Q7Z3S9
Y2H Array
25416956
Intra DHRS1 Q96LJ7 NOTCH2NLA Homo sapiens Q7Z3S9
Y2H Prey Pooling
25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Nevus, Epidermal

Epidermal Nevus

Woolly Hair Nevus

Epidermal Naevus

Epidermal Nevus Syndrome

Nevus, Keratinocytic, Nonepidermolytic

Epidermal Nevus, Somatic

Nevus, Epidermal, Somatic

Nevus Sebaceous Or Woolly Hair Nevus, Somatic

Nonepidermolytic Keratinocytic Nevus

Epidermal Hamartoma Syndrome

Wooly Hair Nevus

Keratinocytic Non-Epidermolytic Nevus

KNEN

Pigmented Moles

Organoid Nevus Phakomatosis

Nevus Sebaceous

Melanocytic Nevus

Melanocytic Nevus Of Skin
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS03738 DHRS1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus DHRS1 RGD RGD:1359172
Mus musculus DHRS1 MGD MGI:1196314
Canis familiaris DHRS1 VGNC VGNC:56058
Bos taurus DHRS1 VGNC VGNC:28039
Macaca mulatta DHRS1 VGNC VGNC:71629
Felis catus DHRS1 VGNC VGNC:61468
Others DHRS1 NCBI
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