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  2. CKS2 - CDC28 protein kinase regulatory subunit 2 Gene

CKS2 - CDC28 protein kinase regulatory subunit 2 Gene

中文名称:CDC28 蛋白激酶调节亚基 2

种属: Homo sapiens

同用名: CKSHS2

基因 ID: 1164 | 基因类型: protein coding

关于 CKS2

Cytogenetic location: 9q22.2 Genomic coordinates (GRCh38): 9:89,311,195-89,316,703 (from NCBI)

This gene has 1 transcript (splice variant), 183 orthologues and 2 paralogues. Broad expression in testis (RPKM 88.8), bone marrow (RPKM 46.4) and 21 other tissues.

功能概要

CKS2 蛋白与细胞周期蛋白依赖性激酶的催化亚基结合,对其生物学功能至关重要。发现 CKS2 mRNA 在 HeLa 细胞的细胞周期中以不同模式表达,这反映了编码蛋白的特殊作用。[RefSeq 提供,2008 年 7 月]

CKS2 protein binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. The CKS2 mRNA is found to be expressed in different patterns through the cell cycle in HeLa cells, which reflects specialized role for the encoded protein. [provided by RefSeq, Jul 2008]

CKS2 基因产物(1)

mRNA Protein Name
NM_001827.3 NP_001818.1 cyclin-dependent kinases regulatory subunit 2
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
2227411 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

CKS2 蛋白结构

CKS

CKS: Cyclin-dependent kinase regulatory subunit (5 - 73)

  • 0
  • 79 a.a.
蛋白主名 其他名称

cyclin-dependent kinases regulatory subunit 2

CDC28 protein kinase 2

CKS2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
CKS2 P33552 CDK3 Homo sapiens Q00526
Validated Y2H
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Coffin-Siris Syndrome 1

Coffin-Siris Syndrome

Fifth Digit Syndrome

Css

CSS1

Mrd12

Mental Retardation, Autosomal Dominant 12

Hhid

Dwarfism-Onychodysplasia

Hypertrichosis, Hyperkeratosis, Mental Retardation, And Distinctive Facial Features

Autosomal Dominant Mental Retardation 12

Short Stature-Onychodysplasia.

Intellectual Disability With Absent Fifth Fingernail And Terminal Phalanx

Mental Retardation With Hypoplastic Fifth Fingernails And Toenails

Short Stature-Onychodysplasia

Coffin-Siris Syndrome, Type 1

Mental Retardation, Autosomal Dominant, Type 12

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Mus musculus CKS2 MGD MGI:1913447
Felis catus CKS2 VGNC VGNC:97381
Bos taurus CKS2 VGNC VGNC:27388
Rattus norvegicus CKS2 RGD RGD:1562047
Canis familiaris CKS2 VGNC VGNC:39293
Macaca mulatta CKS2 VGNC VGNC:104887
Others CKS2 NCBI