CDK3 - cyclin dependent kinase 3 Gene

中文名称：细胞周期蛋白依赖性激酶 3

种属: Homo sapiens

基因 ID: 1018 | 基因类型: protein coding

关于 CDK3

Cytogenetic location: 17q25.1 Genomic coordinates (GRCh38): 17:76,000,855-76,005,998 (from NCBI)

This gene has 3 transcripts (splice variants), 121 orthologues and 26 paralogues. Ubiquitous expression in skin (RPKM 8.9), small intestine (RPKM 6.9) and 25 other tissues.

功能概要

该基因编码细胞周期蛋白依赖性蛋白激酶家族的成员。该蛋白促进进入 S 期，部分是通过激活转录因子 E2F 家族的成员。该蛋白还与细胞周期蛋白 C 结合并磷酸化视网膜母细胞瘤 1 蛋白以促进从 G0 期退出。[RefSeq 提供，2008 年 7 月]

This gene encodes a member of the cyclin-dependent protein kinase family. The protein promotes entry into S phase, in part by activating members of the E2F family of transcription factors. The protein also associates with cyclin C and phosphorylates the retinoblastoma 1 protein to promote exit from G0. [provided by RefSeq, Jul 2008]

CDK3 基因产物(1)

mRNA	Protein	Name
NM_001258.4	NP_001249.1	cyclin-dependent kinase 3

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	9840943	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
acts upstream of or within DNA damage response	IDA IDA: 通过直接分析推断	24550317	GOA
involved in G0 to G1 transition	IDA IDA: 通过直接分析推断	15084261	GOA
involved in negative regulation of Notch signaling pathway	IDA IDA: 通过直接分析推断	25344755	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of cyclin-dependent protein kinase holoenzyme complex	IPI IPI: 通过物理相互作用推断	15084261	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CDK3 蛋白结构

Pkinase

0
100
200
305 a.a.

蛋白主名

其他名称

cyclin-dependent kinase 3

cell division protein kinase 3

CDK3 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	CDK3	Q00526	CCNI	Homo sapiens	Q14094	Validated Y2H	32296183
种属内	CDK3	Q00526	CCNI	Homo sapiens	Q14094	Y2H Array	32296183
种属内	CDK3	Q00526	CCNI	Homo sapiens	Q14094	Y2H Prey Pooling	32296183
种属内	CDK3	Q00526	LHX3	Homo sapiens	Q9UBR4-2	Y2H Prey Pooling	32296183
种属内	CDK3	Q00526	LHX3	Homo sapiens	Q9UBR4-2	Validated Y2H	32296183
种属内	CDK3	Q00526	LHX3	Homo sapiens	Q9UBR4-2	Y2H Array	32296183
种属内	CDK3	Q00526	SPDYE4	Homo sapiens	A6NLX3	Y2H Prey Pooling	32296183
种属内	CDK3	Q00526	SPDYE4	Homo sapiens	A6NLX3	Y2H Array	32296183
种属内	CDK3	Q00526	a0a384nq31_human	Homo sapiens	A0A384NQ31	Y2H Prey Pooling	32296183
种属内	CDK3	Q00526	a0a384nq31_human	Homo sapiens	A0A384NQ31	Y2H Array	32296183
种属内	CDK3	Q00526	OR2G6	Homo sapiens	Q5TZ20	Y2H Prey Pooling	32296183
种属内	CDK3	Q00526	OR2G6	Homo sapiens	Q5TZ20	Validated Y2H	32296183
种属内	CDK3	Q00526	OR2G6	Homo sapiens	Q5TZ20	Y2H Array	32296183
种属内	CDK3	Q00526	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
种属内	CDK3	Q00526	MEOX2	Homo sapiens	Q6FHY5	Validated Y2H	32296183
种属内	CDK3	Q00526	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183
种属内	CDK3	Q00526	PAX8	Homo sapiens	Q06710	Validated Y2H	32296183
种属内	CDK3	Q00526	PAX8	Homo sapiens	Q06710	Y2H Array	32296183
种属内	CDK3	Q00526	LHX4	Homo sapiens	Q969G2	Y2H Prey Pooling	32296183
种属内	CDK3	Q00526	LHX4	Homo sapiens	Q969G2	Validated Y2H	32296183
种属内	CDK3	Q00526	LHX4	Homo sapiens	Q969G2	Y2H Array	32296183
种属内	CDK3	Q00526	PAX5	Homo sapiens	Q02548	Validated Y2H	32296183
种属内	CDK3	Q00526	PAX5	Homo sapiens	Q02548	Y2H Prey Pooling	32296183
种属内	CDK3	Q00526	PAX5	Homo sapiens	Q02548	Y2H Array	32296183
种属内	CDK3	Q00526	HSP90AB1	Homo sapiens	P08238	Anti Tag CoIP	28514442
种属内	CDK3	Q00526	HSP90AB1	Homo sapiens	P08238	Anti Tag CoIP	33961781
种属内	CDK3	Q00526	CCND3	Homo sapiens	P30281	Y2H Prey Pooling	32296183
种属内	CDK3	Q00526	CCND3	Homo sapiens	P30281	Y2H Array	32296183
种属内	CDK3	Q00526	CCNE2	Homo sapiens	O96020	Anti Tag CoIP	33961781
种属内	CDK3	Q00526	CCNE2	Homo sapiens	O96020	Anti Tag CoIP	28514442
种属内	CDK3	Q00526	CDKN1A	Homo sapiens	P38936	Y2H Prey Pooling	32296183
种属内	CDK3	Q00526	CDKN1A	Homo sapiens	P38936	Y2H Array	32296183
种属内	CDK3	Q00526	CDKN1A	Homo sapiens	P38936	Anti Tag CoIP	33961781
种属内	CDK3	Q00526	CDKN1A	Homo sapiens	P38936	TAP	23602568
种属内	CDK3	Q00526	CDKN1A	Homo sapiens	P38936	Anti Tag CoIP	28514442
种属内	CDK3	Q00526	CCNC	Homo sapiens	P24863	Y2H Array	32296183
种属内	CDK3	Q00526	CCNC	Homo sapiens	P24863	Y2H Prey Pooling	32296183
种属内	CDK3	Q00526	CKS1B	Homo sapiens	P61024	Y2H Prey Pooling	32296183
种属内	CDK3	Q00526	CKS1B	Homo sapiens	P61024	TAP	23602568
种属内	CDK3	Q00526	CKS1B	Homo sapiens	P61024	Anti Tag CoIP	33961781
种属内	CDK3	Q00526	CKS1B	Homo sapiens	P61024	Y2H Array	32296183
种属内	CDK3	Q00526	NELFA	Homo sapiens	Q9H3P2	Y2H Array	32296183
种属内	CDK3	Q00526	NELFA	Homo sapiens	Q9H3P2	Y2H Prey Pooling	32296183
种属内	CDK3	Q00526	NELFA	Homo sapiens	Q9H3P2	Validated Y2H	32296183
种属内	CDK3	Q00526	CKS2	Homo sapiens	P33552	Anti Tag CoIP	33961781
种属内	CDK3	Q00526	CKS2	Homo sapiens	P33552	Anti Tag CoIP	28514442
种属内	CDK3	Q00526	CKS2	Homo sapiens	P33552	Y2H Array	32296183
种属内	CDK3	Q00526	CKS2	Homo sapiens	P33552	Y2H Prey Pooling	32296183
种属内	CDK3	Q00526	RACGAP1	Homo sapiens	Q9H0H5	Y2H Array	32296183
种属内	CDK3	Q00526	RACGAP1	Homo sapiens	Q9H0H5	Validated Y2H	32296183
种属内	CDK3	Q00526	RACGAP1	Homo sapiens	Q9H0H5	Y2H Prey Pooling	32296183
种属内	CDK3	Q00526	CCNH	Homo sapiens	P51946	Y2H Array	32296183
种属内	CDK3	Q00526	CCNH	Homo sapiens	P51946	Y2H Prey Pooling	32296183
种属内	CDK3	Q00526	PAX6	Homo sapiens	P26367	Y2H Array	32296183
种属内	CDK3	Q00526	PAX6	Homo sapiens	P26367	Y2H Prey Pooling	32296183
种属内	CDK3	Q00526	OTX2	Homo sapiens	P32243-2	Y2H Prey Pooling	32296183
种属内	CDK3	Q00526	OTX2	Homo sapiens	P32243-2	Y2H Array	32296183
种属内	CDK3	Q00526	FOXP2	Homo sapiens	O15409	Y2H Prey Pooling	32296183
种属内	CDK3	Q00526	FOXP2	Homo sapiens	O15409	Y2H Array	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

CDK3 抗体

目录号	产品名	应用	反应物种
HY-P80797	Phospho-CDK1/2/3 (Thr14) Antibody	WB, IP	Human, Hamster

关联疾病

疾病名称

别名

Retinoblastoma

RB	Trilateral Retinoblastoma
RB1	Retinoblastoma, Trilateral
Neuroblastoma Of Retina	Rb - Retinoblastoma
Eye Cancer, Retinoblastoma	Retinal Cancer
Retinal Tumor	Glioma, Retinal
Non-Hereditary Retinoblastoma	Childhood Cancer Retinoblastoma
Malignant Neoplasm Of Retina	Retinal Neoplasms

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

目录号	产品名	作用方式	纯度	Phase
HY-12871B	Atuveciclib	Inhibitor	99.80%	Phase 1
HY-15504	RGB-286638	Inhibitor	99.70%	Phase 1
HY-137443	Ipivivint	Inhibitor	99.65%	Phase 1
HY-15504A	RGB-286638 free base	Inhibitor	98.07%	Phase 1

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-10329	JNJ-7706621	Inhibitor	99.91%	否
HY-10014	R547	Inhibitor	99.57%	否
HY-119940	MC180295	Inhibitor	98.89%	否
HY-15951	ML167	Inhibitor	98.62%	否
HY-15241	NVP-LCQ195	Inhibitor	98.81%	否
HY-N9561	Vanicoside B	Inhibitor	99.82%	否
HY-X0009A	JSH-009 dimaleate	Inhibitor	/	否
HY-163856	CDK7-IN-30	Inhibitor	/	否
HY-151878	CDK7-IN-20	Inhibitor	/	否
HY-142696	CDK6/PIM1-IN-1	Inhibitor	/	否

直系同源

种属	基因名	来源	基因 ID
Felis catus	CDK3	VGNC	VGNC:107052
Mus musculus	CDK3	MGD	MGI:1916931
Bos taurus	CDK3	VGNC	VGNC:55794
Canis familiaris	CDK3	VGNC	VGNC:51938
Others	CDK3	NCBI

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