1. Gene
  2. CDK3 - cyclin dependent kinase 3 Gene

CDK3 - cyclin dependent kinase 3 Gene

中文名称:细胞周期蛋白依赖性激酶 3

种属: Homo sapiens

基因 ID: 1018 | 基因类型: protein coding

关于 CDK3

Cytogenetic location: 17q25.1 Genomic coordinates (GRCh38): 17:76,000,855-76,005,998 (from NCBI)

This gene has 3 transcripts (splice variants), 121 orthologues and 26 paralogues. Ubiquitous expression in skin (RPKM 8.9), small intestine (RPKM 6.9) and 25 other tissues.

功能概要

该基因编码细胞周期蛋白依赖性蛋白激酶家族的成员。该蛋白促进进入 S 期,部分是通过激活转录因子 E2F 家族的成员。该蛋白还与细胞周期蛋白 C 结合并磷酸化视网膜母细胞瘤 1 蛋白以促进从 G0 期退出。[RefSeq 提供,2008 年 7 月]

This gene encodes a member of the cyclin-dependent protein kinase family. The protein promotes entry into S phase, in part by activating members of the E2F family of transcription factors. The protein also associates with cyclin C and phosphorylates the retinoblastoma 1 protein to promote exit from G0. [provided by RefSeq, Jul 2008]

CDK3 基因产物(1)

mRNA Protein Name
NM_001258.4 NP_001249.1 cyclin-dependent kinase 3
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
9840943 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within DNA damage response IDA
IDA: 通过直接分析推断
24550317 GOA
involved in G0 to G1 transition IDA
IDA: 通过直接分析推断
15084261 GOA
involved in negative regulation of Notch signaling pathway IDA
IDA: 通过直接分析推断
25344755 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of cyclin-dependent protein kinase holoenzyme complex IPI
IPI: 通过物理相互作用推断
15084261 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

CDK3 蛋白结构

Pkinase

Pkinase: Protein kinase domain (4 - 286)

  • 0
  • 100
  • 200
  • 305 a.a.
蛋白主名 其他名称

cyclin-dependent kinase 3

cell division protein kinase 3

关联疾病

疾病名称 别名
Retinoblastoma

RB

Trilateral Retinoblastoma

RB1

Retinoblastoma, Trilateral

Neuroblastoma Of Retina

Rb - Retinoblastoma

Eye Cancer, Retinoblastoma

Retinal Cancer

Retinal Tumor

Glioma, Retinal

Non-Hereditary Retinoblastoma

Childhood Cancer Retinoblastoma

Malignant Neoplasm Of Retina

Retinal Neoplasms

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Felis catus CDK3 VGNC VGNC:107052
Mus musculus CDK3 MGD MGI:1916931
Bos taurus CDK3 VGNC VGNC:55794
Canis familiaris CDK3 VGNC VGNC:51938
Others CDK3 NCBI