1. Gene
  2. CCNE2 - cyclin E2 Gene

CCNE2 - cyclin E2 Gene

中文名称:细胞周期蛋白 E2

种属: Homo sapiens

同用名: CYCE2

基因 ID: 9134 | 基因类型: protein coding

关于 CCNE2

Cytogenetic location: 8q22.1 Genomic coordinates (GRCh38): 8:94,880,224-94,896,693 (from NCBI)

This gene has 8 transcripts (splice variants), 275 orthologues and 18 paralogues. Broad expression in testis (RPKM 6.8), bone marrow (RPKM 6.2) and 20 other tissues.

功能概要

由该基因编码的蛋白质属于高度保守的细胞周期蛋白家族,其成员的特点是在整个细胞周期中蛋白质丰度具有显着的周期性。细胞周期蛋白作为 CDK 激酶的调节剂发挥作用。不同的细胞周期蛋白表现出不同的表达和降解模式,这有助于每个有丝分裂事件的时间协调。该细胞周期蛋白与 CDK2 的调节亚基形成复合物并发挥作用。这种细胞周期蛋白已被证明与 CIP/KIP 家族的 CDK 抑制剂特异性相互作用,并在细胞周期 G1/S 转换中发挥作用。该基因的表达在 G1-S 期达到峰值,并表现出与细胞周期蛋白 E1 不同的组织特异性模式。在肿瘤来源的细胞中观察到该基因的表达水平显着增加。[RefSeq 提供,2008 年 7 月]

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2. This cyclin has been shown to specifically interact with CIP/KIP family of CDK inhibitors, and plays a role in cell cycle G1/S transition. The expression of this gene peaks at the G1-S phase and exhibits a pattern of tissue specificity distinct from that of cyclin E1. A significantly increased expression level of this gene was observed in tumor-derived cells. [provided by RefSeq, Jul 2008]

CCNE2 基因产物(1)

mRNA Protein Name
NM_057749.3 NP_477097.1 G1/S-specific cyclin-E2
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
9840943 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of cyclin E2-CDK2 complex IPI
IPI: 通过物理相互作用推断
15232106 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

CCNE2 蛋白结构

Cyclin_N

Cyclin_N: Cyclin, N-terminal domain (112 - 239)

Cyclin_C

Cyclin_C: Cyclin, C-terminal domain (241 - 361)

  • 0
  • 100
  • 200
  • 300
  • 404 a.a.
蛋白主名 其他名称

G1/S-specific cyclin-E2

CCNE2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
CCNE2 O96020 CDK3 Homo sapiens Q00526
Y2H
9840943
种属内
CCNE2 O96020 CDKN1A Homo sapiens P38936
GMS
24358021
种属内
CCNE2 O96020 CDKN1A Homo sapiens P38936 28514442
种属内
CCNE2 O96020 CDK2 Homo sapiens P24941 9840943
种属内
CCNE2 O96020 CDK2 Homo sapiens P24941
GMS
24358021
种属内
CCNE2 O96020 CDK2 Homo sapiens P24941
Y2H
9840943
种属内
CCNE2 O96020 HTT Homo sapiens P42858 32814053
种属内
CCNE2 O96020 HTT Homo sapiens P42858 32814053
种属内
CCNE2 O96020 HTT Homo sapiens P42858 32814053
种属内
CCNE2 O96020 CDKN1B Homo sapiens P46527 9840943
种属内
CCNE2 O96020 CDKN1B Homo sapiens P46527
GMS
24358021
种属内
CCNE2 O96020 WFS1 Homo sapiens O76024 32814053
种属内
CCNE2 O96020 WFS1 Homo sapiens O76024 32814053
种属内
CCNE2 O96020 WFS1 Homo sapiens O76024 32814053
种属间: 跨种属相互作用 种属内: 同种属相互作用

CCNE2 抗体

目录号 产品名 应用 反应物种
HY-P82849 Cyclin E2 Antibody (YA2594) WB, IHC-F, IHC-P, ICC/IF Human

关联疾病

疾病名称 别名
Retinoblastoma

RB

Trilateral Retinoblastoma

RB1

Retinoblastoma, Trilateral

Neuroblastoma Of Retina

Rb - Retinoblastoma

Eye Cancer, Retinoblastoma

Retinal Cancer

Retinal Tumor

Glioma, Retinal

Non-Hereditary Retinoblastoma

Childhood Cancer Retinoblastoma

Malignant Neoplasm Of Retina

Retinal Neoplasms

Lung Cancer

Lung Carcinoma

Non-Small Cell Lung Carcinoma

Lung Cancer, Susceptibility To

Lung Cancer, Protection Against

Adenocarcinoma Of Lung, Somatic

Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer

Lung Neoplasm

Carcinoma Of Lung

Lung Non-Small Cell Carcinoma

Non-Small Cell Lung Cancer

Nsclc

Lung Neoplasms

Malignant Neoplasm Of Lung

Alveolar Cell Carcinoma

Nonsmall Cell Lung Cancer, Somatic

Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer, Susceptibility To

Lung Cancer, Somatic

Lung Cancer, Resistance To

Cancer Of Lung

Cancer Of Bronchus

Cancer Of The Lung

Lung Malignancies

Lung Malignant Tumors

Malignant Lung Tumor

Malignant Tumor Of Lung

Pulmonary Cancer

Pulmonary Carcinoma

Pulmonary Neoplasms

Respiratory Carcinoma

LNCR

Adenocarcinoma Of Lung

Neoplasm Of Lung

Cancer Lung

Carcinoma Non-Small Cell Lung

Carcinoma, Non-Small-Cell Lung

Lung Cancers

Lung Carcinomas

Cancer, Lung

Cancer, Lung, Non-Small Cell

Primary Malignant Neoplasm Of Lung

Bronchioloalveolar Adenocarcinoma

Pancreatic Cancer

Pancreatic Carcinoma

Carcinoma Of Pancreas

Familial Pancreatic Carcinoma

Pancreatic Neoplasm

Pancreatic Carcinoma, Familial

Malignant Neoplasm Of Pancreas

Pancreatic Acinar Carcinoma

Pancreatic Tumor

Familial Pancreatic Cancer

Neoplasm Of The Pancreas

Cancer Of The Pancreas

Pancreatic Carcinoma, Somatic

Pancreatic Cancer, Somatic

Ca Body Of Pancreas

Ca Head Of Pancreas

Ca Tail Of Pancreas

Malignant Neoplasm Of Body Of Pancreas

Malignant Neoplasm Of Head Of Pancreas

Malignant Neoplasm Of Tail Of Pancreas

Pancreas Neoplasm

Exocrine Cancer

Exocrine Pancreas Carcinoma

Hereditary Pancreatic Cancer

Hereditary Pancreatic Carcinoma

PNCA

Pancreatic Cancer, Susceptibility To

Carcinoma Of Head Of Pancreas

Pancreatic Neoplasms

Pancreatic Tumors

Cancer, Pancreatic

Cancer Of Pancreas

Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site

Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Mus musculus CCNE2 MGD MGI:1329034
Canis familiaris CCNE2 VGNC VGNC:54109
Felis catus CCNE2 VGNC VGNC:60558
Macaca mulatta CCNE2 VGNC VGNC:70728
Bos taurus CCNE2 VGNC VGNC:26967
Rattus norvegicus CCNE2 RGD RGD:1307783
Others CCNE2 NCBI