1. Gene
  2. Slc6a9 - solute carrier family 6 member 9 Gene

Slc6a9 - solute carrier family 6 member 9 Gene

中文名称:溶质载体家族 6 成员 9

种属: Rattus norvegicus

同用名: Glyt1; GLYT-1; GLYT-1b

基因 ID: 116509 | 基因类型: protein coding

关于 Slc6a9

Primary_assembly 5: 131,374,542-131,408,728 forward strand.mRatBN7.2:CM026978.1

This gene has 2 transcripts (splice variants), 206 orthologues, 20 paralogues and is associated with 7 phenotypes. Biased expression in Brain (RPKM 173.1), Liver (RPKM 15.1) and 8 other tissues.

功能概要

该基因编码的蛋白可启动甘氨酸跨膜转运蛋白活性。参与跨质膜的甘氨酸输入。位于致密的核心颗粒中;核内体;和质膜。活跃于海马苔藓纤维至 CA3 突触;与浦肯野细胞突触平行的纤维;和突触后密度。是突触后膜的组成部分;突触前膜的组成部分;和突触小泡膜的组成部分。与人类 SLC6A9(溶质载体家族 6 成员 9)同源。 [由基因组资源联盟提供,2022 年 4 月]

Enables glycine transmembrane transporter activity. Involved in glycine import across plasma membrane. Located in dense core granule; endosome; and plasma membrane. Is active in hippocampal mossy fiber to CA3 synapse; parallel fiber to Purkinje cell synapse; and postsynaptic density. Is integral component of postsynaptic membrane; integral component of presynaptic membrane; and integral component of synaptic vesicle membrane. Orthologous to human SLC6A9 (solute carrier family 6 member 9). [provided by Alliance of Genome Resources, Apr 2022]

Slc6a9 基因产物(1)

mRNA Protein Name
NM_053818.3 NP_446270.1 sodium- and chloride-dependent glycine transporter 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables glycine transmembrane transporter activity IDA
IDA: 通过直接分析推断
12091465 RGD
enables glycine:sodium symporter activity IDA
IDA: 通过直接分析推断
1534013 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
16181645 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in glycine import across plasma membrane IDA
IDA: 通过直接分析推断
12091465 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in asymmetric synapse IDA
IDA: 通过直接分析推断
15749988 RGD
located in dense core granule IDA
IDA: 通过直接分析推断
12091465 RGD
located in endosome IDA
IDA: 通过直接分析推断
12091465 RGD
is active in hippocampal mossy fiber to CA3 synapse IDA
IDA: 通过直接分析推断
15749988 RGD
is active in parallel fiber to Purkinje cell synapse IDA
IDA: 通过直接分析推断
15749988 RGD
located in plasma membrane IDA
IDA: 通过直接分析推断
12091465 RGD
is active in postsynaptic density IDA
IDA: 通过直接分析推断
15749988 RGD
is active in postsynaptic membrane IDA
IDA: 通过直接分析推断
15749988 RGD
is active in presynaptic membrane IDA
IDA: 通过直接分析推断
15749988 RGD
is active in synaptic vesicle membrane IDA
IDA: 通过直接分析推断
24036061 RGD
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

Slc6a9 蛋白结构

SLC6sbd_GlyT1

SLC6sbd_GlyT1: cd11498 (15 - 598)

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  • 638 a.a.
蛋白主名 其他名称

sodium- and chloride-dependent glycine transporter 1

glycine transporter 1

solute carrier family 6 (neurotransmitter transporter, glycine), member 9

Slc6a9 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra Slc6a9 P28572 Dlg4 Rattus norvegicus P31016
Far-WB
16271045
种属间: 跨种属相互作用 种属内: 同种属相互作用

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Slc6a9 NCBI NCBI:6536