Mapk1 - mitogen activated protein kinase 1 Gene

中文名称：有丝分裂原活化蛋白激酶 1

种属: Rattus norvegicus

同用名: ERT1; Erk2; ERK-2; p42-MAPK

关于 Mapk1

功能概要

该基因编码的蛋白可启动多项功能，包括 ATP 绑定活动； MAP 激酶活性；和有丝分裂原活化蛋白激酶激酶激酶结合活性。涉及多个过程，包括ERK1和ERK2级联；蜕化；和大分子生物合成过程的正调控。作用于肽基丝氨酸磷酸化的上游或内部。位于几种细胞成分中，包括小窝；树突细胞质；和周核体。部分含蛋白质复合物。活跃于突触后密度。用于研究冠状动脉疾病（多种）；胃溃疡;大脑中动脉梗塞; 2型糖尿病；和输尿管梗阻。肾纤维化和尿道梗阻的生物标志物。该基因的人类直系同源物与努南综合征 13 相关；腺癌（多发性）；肺动脉高压;和肾细胞癌。与人 MAPK1（丝裂原活化蛋白激酶 1）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables several functions, including ATP binding activity; MAP kinase activity; and mitogen-activated protein kinase kinase kinase binding activity. Involved in several processes, including ERK1 and ERK2 cascade; decidualization; and positive regulation of macromolecule biosynthetic process. Acts upstream of or within peptidyl-serine phosphorylation. Located in several cellular components, including caveola; dendrite cytoplasm; and perikaryon. Part of protein-containing complex. Is active in postsynaptic density. Used to study coronary artery disease (multiple); gastric ulcer; middle cerebral artery infarction; type 2 diabetes mellitus; and ureteral obstruction. Biomarker of renal fibrosis and urethral obstruction. Human ortholog(s) of this gene implicated in Noonan syndrome 13; adenocarcinoma (multiple); pulmonary hypertension; and renal cell carcinoma. Orthologous to human MAPK1 (mitogen-activated protein kinase 1). [provided by Alliance of Genome Resources, Apr 2022]