2. Gene
  3. LRG1 - leucine rich alpha-2-glycoprotein 1 Gene

LRG1 - leucine rich alpha-2-glycoprotein 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：富亮氨酸的 α-2-糖蛋白 1

种属: Homo sapiens

同用名: LRG; HMFT1766

基因 ID: 116844 | 基因类型: protein coding

关于 LRG1

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:4,536,402-4,540,036 (from NCBI)

This gene has 2 transcripts (splice variants), 289 orthologues and 22 paralogues. Biased expression in liver (RPKM 150.7), esophagus (RPKM 16.6) and 4 other tissues.

功能概要

富含亮氨酸重复序列 (LRR) 的蛋白质家族，包括 LRG1，已被证明参与蛋白质-蛋白质相互作用、信号转导以及细胞粘附和发育。 LRG1 在粒细胞分化过程中表达 (O'Donnell 等人，2002 [PubMed 12223515]) 。[OMIM 提供，2008 年 3 月]

The leucine-rich repeat (LRR) family of proteins, including LRG1, have been shown to be involved in protein-protein interaction, signal transduction, and cell adhesion and development. LRG1 is expressed during granulocyte differentiation (O'Donnell et al., 2002 [PubMed 12223515]).[supplied by OMIM, Mar 2008]

LRG1 基因产物(1)

mRNA Protein Name
NM_052972.3 NP_443204.1 leucine-rich alpha-2-glycoprotein precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
23868260 GOA
enables type I transforming growth factor beta receptor binding IPI
IPI: 通过物理相互作用推断
23868260 GOA
enables type II transforming growth factor beta receptor binding IPI
IPI: 通过物理相互作用推断
23868260 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of keratinocyte migration IMP
IMP: 通过突变表型推断
32887674 GOA
acts upstream of leukocyte adhesion to vascular endothelial cell IMP
IMP: 通过突变表型推断
32887674 GOA
acts upstream of positive regulation of angiogenesis IMP
IMP: 通过突变表型推断
32887674 GOA
involved in positive regulation of angiogenesis IMP
IMP: 通过突变表型推断
23868260 GOA
acts upstream of positive regulation of endothelial cell proliferation IMP
IMP: 通过突变表型推断
23868260 GOA
acts upstream of positive regulation of epithelial cell proliferation involved in wound healing IMP
IMP: 通过突变表型推断
32887674 GOA
involved in positive regulation of epithelial to mesenchymal transition IDA
IDA: 通过直接分析推断
32887674 GOA
acts upstream of positive regulation of keratinocyte proliferation IMP
IMP: 通过突变表型推断
32887674 GOA
involved in positive regulation of transforming growth factor beta receptor signaling pathway IDA
IDA: 通过直接分析推断
23868260 GOA
acts upstream of or within wound healing, spreading of epidermal cells IMP
IMP: 通过突变表型推断
32887674 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in extracellular space IDA
IDA: 通过直接分析推断
20363744 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

LRG1 蛋白结构

LRR_1

LRR_1: Leucine Rich Repeat (93 - 111)

LRR_8

LRR_8: Leucine rich repeat (116 - 176)

LRR_1

LRR_1: Leucine Rich Repeat (190 - 208)

LRR_8

LRR_8: Leucine rich repeat (213 - 272)

  • 0
  • 100
  • 200
  • 300
  • 347 a.a.
蛋白主名 其他名称

leucine-rich alpha-2-glycoprotein

1300008B03Rik

LRG1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
LRG1 P02750 ENG Homo sapiens P17813-1
Anti Bait CoIP
23868260
种属内
LRG1 P02750 ENG Homo sapiens P17813-1
SPR
23868260
种属内
LRG1 P02750 TGFBR2 Homo sapiens P37173-2
Anti Bait CoIP
23868260
种属内
LRG1 P02750 TGFBR1 Homo sapiens P36897-1
Anti Bait CoIP
23868260
种属内
LRG1 P02750 CYCS Homo sapiens P99999
Anti Tag CoIP
33961781
种属内
LRG1 P02750 CYCS Homo sapiens P99999
Anti Tag CoIP
28514442
种属内
LRG1 P02750 ACVRL1 Homo sapiens P37023
Anti Bait CoIP
23868260
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 LRG1 蛋白

目录号 产品名 蛋白编号 纯度
HY-P70166 LRG1 Protein, Human (HEK293, His) AAH34389.1  (V36-Q347) ≥95%
HY-P70175 LRG1 Protein, Human (HEK293, Fc-His) P02750/AAH70198.1 (V36-Q347) ≥95%

关联疾病

疾病名称 别名
Appendicitis

Acute Appendicitis

Acute Appendicitis With Generalized Peritonitis

Acute Appendicitis Nos

Acute Appendicitis With Peritoneal Abscess

Appendiceal Inflammation

Appendicitis, Unqualified

Acute Appendix Inflammation

Acute Appendicitis With Diffuse Peritonitis Following Rupture Or Perforation

Acute Appendicitis With Free Peritonitis

Acute Appendicitis With Free Perforation To The Abdominal Cavity

Perforated Appendix With Generalised Peritonitis

Appendicitis With Perforation And Free Pus In The Peritoneal Cavity

Perforated Appendix With Localised Peritonitis

Acute Appendicitis With Contained Perforation To A Localised Abscess

Acute Appendicitis With Localised Peritonitis With Rupture Or Perforation

Acute Appendicitis With Localised Peritonitis Without Rupture Or Perforation

Acute Appendicitis With Perforation And Contained Peritonitis Into An Abscess

Appendicitis With Abscess

Appendicitis With Peritoneal Abscess

Ruptured Appendix Nos

Acute Appendicitis With No Perforation Or Abscess And No Visible Pus

Acute Appendicitis With No Specification If Perforated Or Not

Acute Appendicitis With Phlegmone
Cecal Disease

Cecal Diseases

Disorder Of Cecum
Communicating Hydrocephalus

Acquired Communicating Hydrocephalus
Hydrocephalus

Hydrocephalus, Nonsyndromic, Autosomal Recessive

Hydrocephalus, X-Linked

Hydrocephalus Adverse Event

Hydrocephaly Nos
Normal Pressure Hydrocephalus

Low Pressure Hydrocephalus

Hydrocephalus Normal Pressure

Hydrocephalus, Normal Pressure

Normal Pressure Hydrocephalus Nos

Nph - [Normal Pressure Hydrocephalus]

Normal Pressure Hydrocephaly
Cardiomyopathy, Dilated, 1e

Left Ventricular Noncompaction 9

Left Ventricular Noncompaction 5

Dilated Cardiomyopathy 1e

Dilated Cardiomyopathy 1s

CMD1E

Cdcd2

Cardiomyopathy, Dilated, 1y

CMD1Y

Cardiomyopathy, Dilated, 1s

CMD1S

Dilated Cardiomyopathy 1y

Dilated Cardiomyopathy With Conduction Defect 2

Dilated Cardiomyopathy With Conduction Disorder And Arrhythmia

Cardiomyopathy, Dilated, With Conduction Disorder And Arrhythmia

Cardiomyopathy, Dilated, With Conduction Defect 2

Cardiomyopathy Dilated With Conduction Defect Type 2

Cardiomyopathy, Dilated 1e

Cardiomyopathy, Dilated 1s

Cardiomyopathy, Dilated 1y

Left Ventricular Non-Compaction 5

LVNC5

Left Ventricular Non-Compaction 9

LVNC9

Cardiomyopathy, Dilated, Type 1e

Cardiomyopathy, Dilated, Type 1s

Cardiomyopathy, Dilated, Type 1y
Cardiomyopathy, Familial Hypertrophic, 1

Asymmetric Septal Hypertrophy

Familial Hypertrophic Cardiomyopathy

Hypertrophic Cardiomyopathy 1

CMH1

Hypertrophic Cardiomyopathy 19

CMH

Ventricular Hypertrophy, Hereditary

Ash

Hypertrophic Subaortic Stenosis, Idiopathic

Cardiomyopathy, Familial Hypertrophic

Cardiomyopathy, Hypertrophic, 1, Digenic

Cardiomyopathy, Familial Hypertrophic 1

Hcm

Hereditary Ventricular Hypertrophy

Idiopathic Hypertrophic Subaortic Stenosis

Hypertrophic Cardiomyopathy

Cardiomyopathy, Hypertrophic, Familial

Cardiomyopathy, Hypertrophic, 1

Familial Asymmetric Septal Hypertrophy

Heritable Hypertrophic Cardiomyopathy

Fhc

Cardiomyopathy, Hypertrophic, Familial, Type 1
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS07784 LRG1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus LRG1 RGD RGD:1359464
Macaca mulatta LRG1 VGNC VGNC:74394
Bos taurus LRG1 VGNC VGNC:30980
Felis catus LRG1 VGNC VGNC:102630
Canis familiaris LRG1 VGNC VGNC:42765
Mus musculus LRG1 MGD MGI:1924155
Macaca fascicularis LRG1 NCBI NCBI:102118680
Others LRG1 NCBI
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