2. Gene
  3. Alox15 - arachidonate 15-lipoxygenase Gene

Alox15 - arachidonate 15-lipoxygenase Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：花生四烯酸 15-脂氧合酶

种属: Mus musculus

同用名: 12-LO; 15-LOX; L-12LO; Alox12l; 12/15-LO

基因 ID: 11687 | 基因类型: protein coding

关于 Alox15

Chromosome 11: 70,234,978-70,242,857 reverse strand.GRCm39:CM001004.3

This gene has 2 transcripts (splice variants), 168 orthologues, 6 paralogues and is associated with 23 phenotypes. Broad expression in subcutaneous fat pad adult (RPKM 3.1), ovary adult (RPKM 2.5) and 24 other tissues.

功能概要

该基因编码的蛋白可启动花生四烯酸 12(S)-脂氧合酶活性和花生四烯酸 15-脂氧合酶活性。参与多个过程，包括脂肪酸代谢过程；磷脂酰乙醇胺生物合成过程；和肌动蛋白丝聚合的正调控。作用于骨矿化的上游或内部。位于胞质溶胶和质膜中。以多种结构表达，包括消化系统；肝;鼻子;腹腔积液；和呼吸系统。与人类 ALOX15（花生四烯酸 15-脂氧合酶）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables arachidonate 12(S)-lipoxygenase activity and arachidonate 15-lipoxygenase activity. Involved in several processes, including fatty acid metabolic process; phosphatidylethanolamine biosynthetic process; and positive regulation of actin filament polymerization. Acts upstream of or within bone mineralization. Located in cytosol and plasma membrane. Is expressed in several structures, including alimentary system; liver; nose; peritoneal fluid; and respiratory system. Orthologous to human ALOX15 (arachidonate 15-lipoxygenase). [provided by Alliance of Genome Resources, Apr 2022]

Alox15 基因产物(1)

mRNA Protein Name
NM_009660.3 NP_033790.3 polyunsaturated fatty acid lipoxygenase ALOX15
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables arachidonate 12(S)-lipoxygenase activity IDA
IDA: 通过直接分析推断
8188678 MGI
enables arachidonate 15-lipoxygenase activity IDA
IDA: 通过直接分析推断
8188678 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in apoptotic cell clearance IMP
IMP: 通过突变表型推断
22503541 MGI
involved in arachidonate metabolic process IDA
IDA: 通过直接分析推断
8188678 MGI
involved in arachidonate metabolic process IMP
IMP: 通过突变表型推断
8798642 MGI
acts upstream of or within bone mineralization IMP
IMP: 通过突变表型推断
14716014 MGI
involved in lipoxin A4 biosynthetic process IMP
IMP: 通过突变表型推断
15708862 MGI
involved in lipoxygenase pathway IDA
IDA: 通过直接分析推断
8188678 MGI
involved in lipoxygenase pathway IMP
IMP: 通过突变表型推断
8798642 MGI
involved in negative regulation of adaptive immune response IMP
IMP: 通过突变表型推断
22503541 MGI
acts upstream of or within ossification IMP
IMP: 通过突变表型推断
14716014 MGI
involved in phosphatidylethanolamine biosynthetic process IMP
IMP: 通过突变表型推断
22503541 MGI
involved in positive regulation of actin filament polymerization IMP
IMP: 通过突变表型推断
11278875 MGI
involved in regulation of engulfment of apoptotic cell IMP
IMP: 通过突变表型推断
11278875 MGI
involved in regulation of peroxisome proliferator activated receptor signaling pathway IMP
IMP: 通过突变表型推断
10432118 MGI
involved in response to endoplasmic reticulum stress IMP
IMP: 通过突变表型推断
22215650 MGI
involved in wound healing IMP
IMP: 通过突变表型推断
15708862 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
17426145 MGI
located in cytosol IDA
IDA: 通过直接分析推断
11278875 MGI
located in plasma membrane IDA
IDA: 通过直接分析推断
11278875 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Alox15 蛋白结构

PLAT_LOX

PLAT_LOX: cd01753 (1 - 111)

Lipoxygenase

Lipoxygenase: cl37981 (201 - 653)

  • 0
  • 200
  • 400
  • 600
  • 663 a.a.
蛋白主名 其他名称

polyunsaturated fatty acid lipoxygenase ALOX15

12-LOX

12/15-lipoxygenase

arachidonate 12-lipoxygenase, leukocyte-type

arachidonate omega-6 lipoxygenase

hepoxilin A3 synthase Alox15

linoleate 13S-lipoxygenase

相关产品

Pre-clinical Phase
生物活性分子 (6)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-143787 ALOX15-IN-1 Inhibitor 98.09% 否
HY-143791 ALOX15-IN-2 Inhibitor 99.88% 否
HY-RS00616 ALOX15 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS00617 Alox15 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS00618 Alox15 Rat Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS00619 ALOX15B Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Alox15 NCBI NCBI:246
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