ALOX15 - arachidonate 15-lipoxygenase Gene

中文名称：花生四烯酸 15-脂氧合酶

种属: Homo sapiens

同用名: LOG15; 12-LOX; 15-LOX; 15-LOX-1

基因 ID: 246 | 基因类型: protein coding

关于 ALOX15

Cytogenetic location: 17p13.2 Genomic coordinates (GRCh38): 17:4,630,919-4,641,678 (from NCBI)

This gene has 6 transcripts (splice variants), 168 orthologues and 5 paralogues. Biased expression in lung (RPKM 5.0), small intestine (RPKM 1.7) and 11 other tissues.

功能概要

该基因编码脂氧合酶蛋白质家族的成员。编码的酶作用于各种多不饱和脂肪酸底物，产生各种具有生物活性的脂质介质，如类花生酸、hepoxilins、脂氧素和其他分子。编码的酶及其反应产物已被证明可以调节炎症和免疫力。已在人类基因组中鉴定出该基因的多个假基因。[RefSeq 提供，2017 年 8 月]

This gene encodes a member of the Lipoxygenase family of proteins. The encoded Enzyme acts on various polyunsaturated fatty acid substrates to generate various bioactive lipid mediators such as eicosanoids, hepoxilins, lipoxins, and Other molecules. The encoded Enzyme and its reaction products have been shown to regulate inflammation and immunity. Multiple pseudogenes of this gene have been identified in the human genome. [provided by RefSeq, Aug 2017]

ALOX15 基因产物(1)

mRNA	Protein	Name
NM_001140.5	NP_001131.3	polyunsaturated fatty acid lipoxygenase ALOX15

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables arachidonate 12(S)-lipoxygenase activity	IDA IDA: 通过直接分析推断	1944593	GOA
enables arachidonate 15-lipoxygenase activity	IDA IDA: 通过直接分析推断	1944593	GOA
enables linoleate 13S-lipoxygenase activity	IDA IDA: 通过直接分析推断	8334154	GOA
enables phosphatidylinositol-4,5-bisphosphate binding	IDA IDA: 通过直接分析推断	17052953	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	21831839	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in arachidonate metabolic process	IDA IDA: 通过直接分析推断	1944593	GOA
involved in cellular response to calcium ion	IDA IDA: 通过直接分析推断	17052953	GOA
involved in cellular response to interleukin-13	IMP IMP: 通过突变表型推断	21831839	GOA
involved in linoleic acid metabolic process	IDA IDA: 通过直接分析推断	8334154	GOA
involved in lipid metabolic process	IDA IDA: 通过直接分析推断	23242647	GOA
involved in lipoxygenase pathway	IDA IDA: 通过直接分析推断	1944593	GOA
involved in positive regulation of ERK1 and ERK2 cascade	IMP IMP: 通过突变表型推断	21831839	GOA
involved in positive regulation of cell-substrate adhesion	IDA IDA: 通过直接分析推断	11278875	GOA
involved in regulation of inflammatory response	IDA IDA: 通过直接分析推断	23242647	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cytoplasmic side of plasma membrane	IDA IDA: 通过直接分析推断	17052953	GOA
located in cytosol	IDA IDA: 通过直接分析推断	17052953	GOA
located in lipid droplet	IDA IDA: 通过直接分析推断	19528634	GOA
located in membrane	IDA IDA: 通过直接分析推断	21831839	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ALOX15 蛋白结构

PLAT

Lipoxygenase

0
200
400
600
662 a.a.

蛋白主名

其他名称

polyunsaturated fatty acid lipoxygenase ALOX15

12/15-lipoxygenase	15-LOX type 1
15-lipooxygenase-1	15-lipoxygenase type 1
arachidonate 12-lipoxygenase, leukocyte-type	arachidonate omega-6 lipoxygenase
hepoxilin A3 synthase Alox15	linoleate 13S-lipoxygenase

ALOX15 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	ALOX15	P16050	TIMM29	Homo sapiens	Q9BSF4	Anti Tag CoIP	28514442
种属内	ALOX15	P16050	TIMM29	Homo sapiens	Q9BSF4	Anti Tag CoIP	33961781

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Ichthyosis, Congenital, Autosomal Recessive 3

Autosomal Recessive Congenital Ichthyosis 3	ARCI3
Lamellar Ichthyosis 5	Collodion Baby, Self-Healing
Ichthyosis, Lamellar, 5, Formerly	Li5, Formerly
Li5	Self-Healing Collodion Baby
Ichthyosis, Congenital, Autosomal Recessive, Type 3

Malaria

Malaria, Susceptibility To	Malaria, Resistance To
Malaria, Cerebral	Cerebral Malaria
Malaria, Severe, Susceptibility To	Malaria, Severe, Resistance To
Malaria, Cerebral, Susceptibility To	Induced Malaria
Malaria, Vivax, Protection Against	Malaria, Severe
Malaria, Cerebral, Reduced Risk Of	Malaria, Protection Against
Resistance To Malaria Due To G6pd Deficiency	Malaria Due To G6pd Deficiency
Malarial Encephalitis	CM
Malaria Cerebral	Susceptibility To Malaria
Acute Pernicious Fever	Aestivo-Autumnal Fever
Aestivo Autumnal Malaria	Chagres Fever
Continued Malaria Fever	Estivo-Autumnal Fever
Estivo-Autumnal Malaria	Estivo-Autumnal Malarial Fever
Falciparum Fever	Malignant Tertian Fever
Malignant Tertian Malaria	Pernicious Intermittent Fever
Pernicious Malaria	Quotidian Malaria
Subtertian Fever	Subtertian Malaria Fever
Subtertian Malignant Tertian Malaria	Tropical Malaria
Algid Malaria	Bilious Haemoglobinuric Fever
Black Water Fever	Blackwater Fever
Malarial Blackwater Fever	Severe Malarial Falciparum
West African Fever	Malarial Haematinuria
Haemoglobinuric Fever	Haemoglobinuric Malaria
Severe Plasmodium Falciparum Malaria	Malarial Haemoglobinuria
Malarial Haematuria	Falciparum Malaria [Malignant Tertian]
Malaria Tropica	Malarial Shock
Chagres Virus Disease	Malignant Malaria
Mtm - [Malignant Tertian Malaria]	Tm -[Malignant Tertian Malaria]
Panama Fever	St - [Subtertian Malaria]
Malarial Quotidian	Benign Tertian Malaria
Tertian Ague	Vivax Fever
Plasmodium Vivax Malaria Nos	Btm - [Benign Tertian Malaria]
Bt - [Benign Tertian Malaria]	Vivax Malaria
Benign Tertian Vivax Malaria	Tertian Malaria
Quartan Malaria	Quartan Ague
Quartan Fever	Plasmodium Malariae Malaria Nos
Quartan Malarial	Malaria By Plasmodium Malariae
Malariae Malaria	Ovale Tertian Malaria
Plasmodium Ovale Fever	Malaria Fever By Plasmodium Ovale
Ovale Malaria	Malaria By Plasmodium Ovale
Malarial Ovale	Marsh Fever
Remittent Congestive Fever	Coastal Fever
Remittent Gastric Fever	Miasmatic Fever
Congestive Remittent Fever	Intermittent Fever
Jungle Fever	Paludism
Cameroon Fever	Ague
Corsican Fever	Intermittent Bilious Fever
Disease Due To Plasmodiidae	Malarial Fever
Plasmodiosis	Remittent Fever
Roman Fever	Malaria Fever Nos
Malaria Nos	Paludal Fever
Clinically Diagnosed Malaria	Clinically Diagnosed Malaria Without Parasitological Confirmation
Congestive Fever	Malarial Cachexia
Marsh Cachexia	Paludal Cachexia
Recurrent Malaria	Remittent Malaria

Cone-Rod Dystrophy 17

CORD17

Asthma

Chronic Obstructive Asthma	Asthma, Diminished Response To Antileukotriene Treatment In
Bronchial Hyperreactivity	Asthma, Susceptibility To
Asthma, Bronchial	Asthma, Protection Against
Asthma, Nocturnal, Susceptibility To	Nocturnal Asthma
Asthma-Related Traits	Asthma-Related Traits, Susceptibility To
Asthma, Nocturnal	Chronic Obstructive Asthma With Acute Exacerbation
Chronic Obstructive Asthma With Status Asthmaticus	Exercise Induced Asthma
Exercise-Induced Asthma	Bronchial Asthma
Asthma, Exercise-Induced	Idiosyncratic Asthma
Unspecified Asthma With Acute Exacerbation	Asthma, Unspecified, With Stated Status Asthmaticus
Status Asthmaticus Nos	Acute Severe Asthma
Acute Severe Bronchial Asthma	Status Asthma
Status Post Asthmaticus

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-143787	ALOX15-IN-1	Inhibitor	98.09%	否
HY-143791	ALOX15-IN-2	Inhibitor	99.88%	否
HY-RS00616	ALOX15 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS00617	Alox15 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS00618	Alox15 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS00619	ALOX15B Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Bos taurus	ALOX15	VGNC	VGNC:25843
Mus musculus	ALOX15	MGD	MGI:87997
Rattus norvegicus	ALOX15	RGD	RGD:70493
Macaca mulatta	ALOX15	VGNC	VGNC:69796
Canis familiaris	ALOX15	VGNC	VGNC:37811
Others	ALOX15	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

ALOX15 - arachidonate 15-lipoxygenase Gene

关于 ALOX15

功能概要

ALOX15 基因产物(1)

ALOX15 蛋白结构

ALOX15 蛋白互作信息

关联疾病

直系同源

热门区域

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ALOX15 - arachidonate 15-lipoxygenase Gene

关于 ALOX15

功能概要

ALOX15 基因产物(1)

ALOX15 蛋白结构

ALOX15 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

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B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z