2. Gene
  3. P2ry6 - pyrimidinergic receptor P2Y6 Gene

P2ry6 - pyrimidinergic receptor P2Y6 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：嘧啶能受体 P2Y6

种属: Rattus norvegicus

同用名: P2y6

基因 ID: 117264 | 基因类型: protein coding

关于 P2ry6

Primary_assembly 1: 155,295,111-155,330,808 reverse strand.mRatBN7.2:CM026974.1

This gene has 5 transcripts (splice variants), 183 orthologues, 13 paralogues and is associated with 1 phenotype. Biased expression in Spleen (RPKM 12.8), Heart (RPKM 6.9) and 9 other tissues.

功能概要

预测该基因编码的蛋白可启动 G 蛋白偶联的 ADP 受体活性； G蛋白偶联的UDP受体活性；和 G 蛋白偶联的 UTP 受体活性。参与多个过程，包括细胞对嘧啶核糖核苷酸的反应；肌醇 1,4,5-三磷酸敏感钙释放通道活性的正向调节；和平滑肌细胞迁移的正调节。位于顶端质膜和基底外侧质膜。与人 P2RY6（嘧啶能受体 P2Y6）同源。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable G protein-coupled ADP receptor activity; G protein-coupled UDP receptor activity; and G protein-coupled UTP receptor activity. Involved in several processes, including cellular response to pyrimidine ribonucleotide; positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; and positive regulation of smooth muscle cell migration. Located in apical plasma membrane and basolateral plasma membrane. Orthologous to human P2RY6 (pyrimidinergic receptor P2Y6). [provided by Alliance of Genome Resources, Apr 2022]

P2ry6 基因产物(1)

mRNA Protein Name
NM_057124.2 NP_476465.1 P2Y purinoceptor 6
基因本体论
  • 生物过程
  • 细胞组分
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to pyrimidine ribonucleotide IMP
IMP: 通过突变表型推断
17410128 RGD
involved in phagocytosis IMP
IMP: 通过突变表型推断
17410128 RGD
involved in positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity IMP
IMP: 通过突变表型推断
17410128 RGD
involved in positive regulation of smooth muscle cell migration IMP
IMP: 通过突变表型推断
11934835 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in apical plasma membrane IDA
IDA: 通过直接分析推断
11557527 RGD
located in basolateral plasma membrane IDA
IDA: 通过直接分析推断
11557527 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

P2ry6 蛋白结构

7tm_GPCRs

7tm_GPCRs: cl28897 (26 - 311)

7tm_GPCRs

7tm_GPCRs: cd14964 (28 - 52)

7tm_GPCRs

7tm_GPCRs: cd14964 (61 - 82)

7tm_GPCRs

7tm_GPCRs: cd14964 (99 - 121)

7tm_GPCRs

7tm_GPCRs: cd14964 (145 - 161)

7tm_GPCRs

7tm_GPCRs: cd14964 (189 - 212)

7tm_GPCRs

7tm_GPCRs: cd14964 (237 - 259)

7tm_GPCRs

7tm_GPCRs: cd14964 (279 - 304)

  • 0
  • 100
  • 200
  • 300
  • 328 a.a.
蛋白主名 其他名称

P2Y purinoceptor 6

P2Y ATP receptor 6

pyrimidinergic receptor P2Y, G-protein coupled, 6

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS09934 P2RY6 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS09935 P2ry6 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS09936 P2ry6 Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens P2ry6 NCBI NCBI:5031
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