Apc - APC, WNT signaling pathway regulator Gene

中文名称：APC、WNT 信号通路调节因子

种属: Mus musculus

同用名: CC1; Min; mAPC

关于 Apc

功能概要

该基因编码的蛋白可启动多种功能，包括 β-连环蛋白结合活性；动力蛋白复合物结合活性；和酶结合活性。参与胰岛素受体信号通路；冷诱导产热的正调节；和蛋白质定位到中心体的正调节。作用于多个过程的上游或内部，包括动物器官发育；区域化；和调节微管聚合或解聚。位于多个细胞成分中，包括轴突生长锥；细胞投射膜；和微管细胞骨架。 Scrib-APC-β-连环蛋白复合物的一部分。以多种结构表达，包括消化系统；中枢神经系统;泌尿生殖系统；周围神经系统神经节；和视网膜。用于研究乳腺癌；家族性腺瘤性息肉病；胃肠系统癌症（多发性）；和生殖器官癌（多发性）。该基因的人类直系同源物与多种疾病有关，包括癌（多种）；子宫内膜癌（多发性）；家族性腺瘤性息肉病 1；遗传性硬纤维瘤病；和髓母细胞瘤。与人类 APC 同源（WNT 信号通路的 APC 调节剂）。 [由基因组资源联盟提供，2022 年 4 月]

Enables several functions, including beta-catenin binding activity; dynein complex binding activity; and Enzyme binding activity. Involved in Insulin Receptor signaling pathway; positive regulation of cold-induced thermogenesis; and positive regulation of protein localization to centrosome. Acts upstream of or within several processes, including animal organ development; regionalization; and regulation of microtubule polymerization or depolymerization. Located in several cellular components, including axonal growth cone; cell projection membrane; and microtubule Cytoskeleton. Part of Scrib-APC-beta-catenin complex. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; peripheral nervous system ganglion; and retina. Used to study breast cancer; familial adenomatous polyposis; gastrointestinal system Cancer (multiple); and reproductive organ Cancer (multiple). Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); endometrial Cancer (multiple); familial adenomatous polyposis 1; hereditary desmoid disease; and medulloblastoma. Orthologous to human APC (APC regulator of Wnt signaling pathway). [provided by Alliance of Genome Resources, Apr 2022]