Apc - APC regulator of WNT signaling pathway Gene

中文名称：WNT 信号通路的 APC 调节因子

种属: Rattus norvegicus

同用名: RATAPC

关于 Apc

功能概要

该基因编码的蛋白可启动微管结合活动。参与多个过程，包括细胞对神经生长因子刺激的反应；心肌细胞增殖的负调节；和调节谷氨酸代谢过程。位于多个细胞成分中，包括轴突生长锥；胞体纤维；和侧质膜。部分含蛋白质复合物。与神经元投射和突触共定位。用于研究贫血；结肠腺癌；结肠癌;和家族性腺瘤性息肉病。该基因的人类直系同源物与多种疾病有关，包括癌（多种）；子宫内膜癌（多发性）；家族性腺瘤性息肉病 1；遗传性硬纤维瘤病；和髓母细胞瘤。与人类 APC 同源（WNT 信号通路的 APC 调节剂）。 [由基因组资源联盟提供，2022 年 4 月]

Enables microtubule binding activity. Involved in several processes, including cellular response to nerve growth factor stimulus; negative regulation of cardiac muscle cell proliferation; and regulation of glutamate metabolic process. Located in several cellular components, including axonal growth cone; cell body fiber; and lateral plasma membrane. Part of protein-containing complex. Colocalizes with neuron projection and synapse. Used to study anemia; colon adenocarcinoma; colon cancer; and familial adenomatous polyposis. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); endometrial Cancer (multiple); familial adenomatous polyposis 1; hereditary desmoid disease; and medulloblastoma. Orthologous to human APC (APC regulator of Wnt signaling pathway). [provided by Alliance of Genome Resources, Apr 2022]