2. Gene
  3. GSTO2 - glutathione S-transferase omega 2 Gene

GSTO2 - glutathione S-transferase omega 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：谷胱甘肽 S-转移酶 omega 2

种属: Homo sapiens

同用名: GSTO 2-2; bA127L20.1

基因 ID: 119391 | 基因类型: protein coding

关于 GSTO2

Cytogenetic location: 10q25.1 Genomic coordinates (GRCh38): 10:104,269,184-104,304,950 (from NCBI)

This gene has 7 transcripts (splice variants), 542 orthologues and 14 paralogues. Broad expression in skin (RPKM 2.1), testis (RPKM 1.8) and 21 other tissues.

功能概要

该基因编码的蛋白质是一种欧米茄类谷胱甘肽 S-转移酶 (GST) 。 GST 参与外源物质和致癌物质的代谢。已发现该基因编码不同亚型的四种转录变体。[RefSeq 提供，2010 年 7 月]

The protein encoded by this gene is an omega class Glutathione S-transferase (GST). GSTs are involved in the metabolism of xenobiotics and carcinogens. Four transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2010]

GSTO2 基因产物(4)

mRNA Protein Name
NM_001191013.2 NP_001177942.1 glutathione S-transferase omega-2 isoform 2
NM_001191014.2 NP_001177943.1 glutathione S-transferase omega-2 isoform 3
NM_001191015.2 NP_001177944.1 glutathione S-transferase omega-2 isoform 4
NM_183239.2 NP_899062.1 glutathione S-transferase omega-2 isoform 1
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables glutathione dehydrogenase (ascorbate) activity IDA
IDA: 通过直接分析推断
15970797 GOA
enables identical protein binding IPI
IPI: 通过物理相互作用推断
25416956 GOA
enables oxidoreductase activity IDA
IDA: 通过直接分析推断
15970797 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
25416956 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in L-ascorbic acid metabolic process IDA
IDA: 通过直接分析推断
15970797 GOA
involved in cellular response to arsenic-containing substance IDA
IDA: 通过直接分析推断
15970797 GOA
involved in xenobiotic metabolic process IDA
IDA: 通过直接分析推断
15970797 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

GSTO2 蛋白结构

GST_N_3

GST_N_3: Glutathione S-transferase, N-terminal domain (27 - 100)

GST_C_2

GST_C_2: Glutathione S-transferase, C-terminal domain (143 - 204)

  • 0
  • 100
  • 200
  • 243 a.a.
蛋白主名 其他名称

glutathione S-transferase omega-2

GSTO-2

GSTO2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
GSTO2 Q9H4Y5 GSTO2 Homo sapiens Q9H4Y5
Validated Y2H
32296183
种属内
GSTO2 Q9H4Y5 GSTO2 Homo sapiens Q9H4Y5
Y2H Array
25416956
种属内
GSTO2 Q9H4Y5 GSTO2 Homo sapiens Q9H4Y5
Y2H Array
32296183
种属内
GSTO2 Q9H4Y5 MUM1 Homo sapiens Q9H6H2
Validated Y2H
25416956
种属内
GSTO2 Q9H4Y5 GSTO2 Homo sapiens Q9H4Y5
Y2H Prey Pooling
32296183
种属内
GSTO2 Q9H4Y5 INCA1 Homo sapiens Q0VD86
Y2H Array
32296183
种属内
GSTO2 Q9H4Y5 TFAP2A Homo sapiens P05549
Y2H Prey Pooling
25416956
种属内
GSTO2 Q9H4Y5 TFAP2A Homo sapiens P05549
Y2H Array
25416956
种属内
GSTO2 Q9H4Y5 MUM1 Homo sapiens Q9H6H2
Y2H Prey Pooling
25416956
种属内
GSTO2 Q9H4Y5 INCA1 Homo sapiens Q0VD86
Y2H Prey Pooling
32296183
种属内
GSTO2 Q9H4Y5 PFDN5 Homo sapiens Q99471
Y2H Array
32296183
种属内
GSTO2 Q9H4Y5 PFDN5 Homo sapiens Q99471
Y2H Prey Pooling
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Chronic Closed-Angle Glaucoma

Anatomical Narrow Angle Glaucoma

Chronic Angle-Closure Glaucoma

Chronic Narrow Angle Glaucoma

Secondary Angle-Closure Glaucoma - Synechial
Cataract

Cataracts

Cat - [Cataract]

Cataract Form

Lens Opacity

Lens Opacities
Parkinson Disease, Late-Onset

Parkinson Disease

Parkinson'S Disease

PD

PARK

Parkinson Disease, Susceptibility To

Late Onset Parkinson'S Disease

Late Onset Parkinson Disease

Paralysis Agitans

Primary Parkinsonism

Idiopathic Parkinson Disease

Parkinson'S

Parkinson Disease, Late-Onset, Susceptibility To

Parkinson Disease, Age Of Onset, Modifier

Lewy Body Parkinson Disease

Idiopathic Parkinson'S Disease

Pd - [Parkinson Disease]

Parkinson Disease Nos

Parkinson, Nos

Primary Parkinson Disease
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS05885 GSTO2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris GSTO2 VGNC VGNC:110343
Mus musculus GSTO2 MGD MGI:1915464
Macaca mulatta GSTO2 VGNC VGNC:106055
Bos taurus GSTO2 VGNC VGNC:29687
Felis catus GSTO2 VGNC VGNC:62732
Rattus norvegicus GSTO2 RGD RGD:1310764
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