Cckbr - cholecystokinin B receptor Gene

中文名称：胆囊收缩素B受体

种属: Mus musculus

同用名: CCK2R; CCK-BR; CCK2-R; CCKR-2

关于 Cckbr

功能概要

该基因编码在中枢神经系统和胃肠道中表达的多通道跨膜受体蛋白。胆囊收缩素和胃泌素与编码的蛋白质结合，刺激胃肠道中的胃酸分泌和粘膜生长，以及大脑中的焦虑、痛觉和记忆。缺乏编码蛋白的小鼠表现出基础胃 pH 值和血液中胃泌素水平升高，以及轻度低钙血症、继发性甲状旁腺功能亢进和骨吸收增加。 [RefSeq 提供，2015 年 4 月]

This gene encodes a multipass transmembrane receptor protein expressed in the central nervous system and gastrointestinal tract. Cholecystokinin and Gastrin bind to the encoded protein to stimulate gastric acid secretion and mucosal growth in the gastrointestinal tract, and anxiety, pain sensation and memory in the brain. Mice lacking the encoded protein exhibit an increase in the basal gastric pH and Gastrin levels in the bloodstream as well as mild hypocalcemia, secondary hyperparathyroidism and increased bone resorption. [provided by RefSeq, Apr 2015]