1. Gene
  2. SLC43A2 - solute carrier family 43 member 2 Gene

SLC43A2 - solute carrier family 43 member 2 Gene

中文名称:溶质载体家族 43 成员 2

种属: Homo sapiens

同用名: LAT4

基因 ID: 124935 | 基因类型: protein coding

关于 SLC43A2

Cytogenetic location: 17p13.3 Genomic coordinates (GRCh38): 17:1,569,254-1,630,088 (from NCBI)

This gene has 12 transcripts (splice variants), 1 gene allele, 283 orthologues and 1 paralogue. Broad expression in placenta (RPKM 24.5), kidney (RPKM 14.0) and 16 other tissues.

功能概要

该基因编码 L-氨基酸转运蛋白 3 或 SLC43 转运蛋白家族的成员。编码的蛋白质介导中性氨基酸 L 异构体 (包括亮氨酸、苯丙氨酸、缬氨酸和甲硫氨酸) 的钠、氯和 pH 独立转运。这种蛋白质可能有助于将氨基酸通过胎盘膜转移给胎儿。[RefSeq 提供,2016 年 3 月]

This gene encodes a member of the L-amino acid transporter-3 or SLC43 family of transporters. The encoded protein mediates sodium-, chloride-, and pH-independent transport of L-isomers of neutral Amino acids, including leucine, phenylalanine, valine and methionine. This protein may contribute to the transfer of Amino acids across the placental membrane to the fetus. [provided by RefSeq, Mar 2016]

SLC43A2 基因产物(5)

mRNA Protein Name
NM_001284498.2 NP_001271427.1 large neutral amino acids transporter small subunit 4 isoform 1
NM_001284499.1 NP_001271428.1 large neutral amino acids transporter small subunit 4 isoform 3
NM_001321364.2 NP_001308293.1 large neutral amino acids transporter small subunit 4 isoform 1
NM_001321365.2 NP_001308294.1 large neutral amino acids transporter small subunit 4 isoform 1
NM_152346.3 NP_689559.1 large neutral amino acids transporter small subunit 4 isoform 2
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables L-isoleucine transmembrane transporter activity IDA
IDA: 通过直接分析推断
15659399 GOA
enables L-leucine transmembrane transporter activity IDA
IDA: 通过直接分析推断
15659399 GOA
enables L-methionine transmembrane transporter activity IDA
IDA: 通过直接分析推断
15659399 GOA
enables L-phenylalanine transmembrane transporter activity IDA
IDA: 通过直接分析推断
30379325 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in L-leucine transport IDA
IDA: 通过直接分析推断
15659399 GOA
involved in isoleucine transport IDA
IDA: 通过直接分析推断
15659399 GOA
involved in methionine transport IDA
IDA: 通过直接分析推断
15659399 GOA
acts upstream of or within negative regulation of L-leucine import across plasma membrane IDA
IDA: 通过直接分析推断
26305885 GOA
acts upstream of or within negative regulation of amino acid transport IDA
IDA: 通过直接分析推断
26305885 GOA
involved in phenylalanine transport IDA
IDA: 通过直接分析推断
30379325 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

SLC43A2 蛋白结构

MFS_1

MFS_1: Major Facilitator Superfamily (87 - 387)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 569 a.a.
蛋白主名 其他名称

large neutral amino acids transporter small subunit 4

L-type amino acid transporter 4

SLC43A2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
SLC43A2 Q8N370 KRT35 Homo sapiens Q92764 32296183
种属内
SLC43A2 Q8N370 KRT35 Homo sapiens Q92764 32296183
种属内
SLC43A2 Q8N370 KRT35 Homo sapiens Q92764 32296183
种属内
SLC43A2 Q8N370 KRTAP1-3 Homo sapiens Q8IUG1 32296183
种属内
SLC43A2 Q8N370 KRTAP1-3 Homo sapiens Q8IUG1 32296183
种属内
SLC43A2 Q8N370 KRTAP1-1 Homo sapiens Q07627 32296183
种属内
SLC43A2 Q8N370 KRTAP1-1 Homo sapiens Q07627 32296183
种属内
SLC43A2 Q8N370 NOTCH2NLC Homo sapiens P0DPK4 32296183
种属内
SLC43A2 Q8N370 NOTCH2NLC Homo sapiens P0DPK4 32296183
种属内
SLC43A2 Q8N370 CYSRT1 Homo sapiens A8MQ03 32296183
种属内
SLC43A2 Q8N370 CYSRT1 Homo sapiens A8MQ03 32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus SLC43A2 RGD RGD:1305819
Mus musculus SLC43A2 MGD MGI:2442746
Macaca mulatta SLC43A2 VGNC VGNC:77554
Bos taurus SLC43A2 VGNC VGNC:34875
Felis catus SLC43A2 VGNC VGNC:65370
Canis familiaris SLC43A2 VGNC VGNC:46416