2. Gene
  3. Cd3e - CD3 antigen, epsilon polypeptide Gene

Cd3e - CD3 antigen, epsilon polypeptide Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: CD3; T3e; CD3epsilon

基因 ID: 12501 | 基因类型: protein coding

关于 Cd3e

功能概要

Predicted to enable several functions, including SH3 domain binding activity; identical protein binding activity; and protein heterodimerization activity. Involved in nervous system development and positive regulation of cell adhesion. Acts upstream of or within several processes, including positive regulation of T cell activation; positive regulation of cytokine production; and regulation of signal transduction. Located in several cellular components, including dendritic spine; external side of plasma membrane; and immunological synapse. Part of alpha-beta T cell receptor complex. Is expressed in colon and hemolymphoid system. Human ortholog(s) of this gene implicated in immunodeficiency 18. Orthologous to human CD3e (CD3e molecule). [provided by Alliance of Genome Resources, Apr 2022]

Cd3e 基因产物(1)

mRNA Protein Name
NM_007648.5 NP_031674.1 T-cell surface glycoprotein CD3 epsilon chain precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
8196616 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of CD4-positive, alpha-beta T cell proliferation IDA
IDA: 通过直接分析推断
8125140 MGI
acts upstream of T cell activation IDA
IDA: 通过直接分析推断
12874832 MGI
acts upstream of T cell anergy IDA
IDA: 通过直接分析推断
14973438 MGI
acts upstream of or within T cell costimulation IGI
IGI: 通过遗传相互作用推断
23793062 MGI
acts upstream of T cell proliferation IDA
IDA: 通过直接分析推断
10072077 MGI
acts upstream of or within T cell receptor signaling pathway IDA
IDA: 通过直接分析推断
10485657 MGI
acts upstream of or within apoptotic signaling pathway IDA
IDA: 通过直接分析推断
8666928 MGI
acts upstream of calcium-mediated signaling IDA
IDA: 通过直接分析推断
7630421 MGI
acts upstream of or within cell surface receptor signaling pathway IDA
IDA: 通过直接分析推断
7630421 MGI
involved in cerebellum development IMP
IMP: 通过突变表型推断
17502348 MGI
involved in dendrite development IMP
IMP: 通过突变表型推断
17502348 MGI
acts upstream of interleukin-4 production IDA
IDA: 通过直接分析推断
11894097 MGI
acts upstream of or within lymphocyte activation IMP
IMP: 通过突变表型推断
15843560 MGI
acts upstream of or within negative regulation of smoothened signaling pathway IDA
IDA: 通过直接分析推断
10981962 MGI
acts upstream of or within negative thymic T cell selection IDA
IDA: 通过直接分析推断
7630421 MGI
acts upstream of peptidyl-tyrosine phosphorylation IDA
IDA: 通过直接分析推断
10485657 MGI
acts upstream of or within positive regulation of CD4-positive, alpha-beta T cell proliferation IDA
IDA: 通过直接分析推断
8125140 MGI
acts upstream of or within positive regulation of T cell activation IDA
IDA: 通过直接分析推断
12874832 MGI
acts upstream of or within positive regulation of T cell anergy IDA
IDA: 通过直接分析推断
14973438 MGI
acts upstream of or within positive regulation of T cell proliferation IDA
IDA: 通过直接分析推断
10072077 MGI
acts upstream of or within positive regulation of calcium-mediated signaling IDA
IDA: 通过直接分析推断
7630421 MGI
involved in positive regulation of cell-cell adhesion mediated by integrin IGI
IGI: 通过遗传相互作用推断
12652296 MGI
involved in positive regulation of cell-matrix adhesion IGI
IGI: 通过遗传相互作用推断
12652296 MGI
acts upstream of or within positive regulation of interleukin-2 production IDA
IDA: 通过直接分析推断
12874832 MGI
acts upstream of or within positive regulation of interleukin-4 production IDA
IDA: 通过直接分析推断
11894097 MGI
acts upstream of or within positive regulation of peptidyl-tyrosine phosphorylation IDA
IDA: 通过直接分析推断
10485657 MGI
acts upstream of or within positive regulation of type II interferon production IDA
IDA: 通过直接分析推断
11894097 MGI
acts upstream of smoothened signaling pathway IDA
IDA: 通过直接分析推断
10981962 MGI
acts upstream of type II interferon production IDA
IDA: 通过直接分析推断
11894097 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of alpha-beta T cell receptor complex IDA
IDA: 通过直接分析推断
9064344 MGI
located in cell body IDA
IDA: 通过直接分析推断
17502348 MGI
located in cell-cell junction IDA
IDA: 通过直接分析推断
23793062 MGI
located in dendritic spine IDA
IDA: 通过直接分析推断
17502348 MGI
located in external side of plasma membrane IDA
IDA: 通过直接分析推断
7630421 MGI
located in immunological synapse IDA
IDA: 通过直接分析推断
14635057 MGI
located in plasma membrane IDA
IDA: 通过直接分析推断
17502348 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

T-cell surface glycoprotein CD3 epsilon chain

T-cell surface antigen T3/Leu-4 epsilon chain

重组 Cd3e 蛋白

目录号 产品名 蛋白编号 纯度
HY-P71723 CD3 epsilon Protein, Mouse (P.pastoris, His) P22646 (D23-D108) ≥95%
HY-P75414 CD3E-CD3G Heterodimer Protein, Mouse (HEK293, Fc) NP_031674.1 (D23-D108)&NP_033980.1 (Q23-S116) ≥95%
HY-P75415 CD3D-CD3E Heterodimer Protein, Mouse (HEK293, Flag-His) P04235 (F22-A105)&P22646 (D22-D108) ≥95%
HY-P75416 CD3D-CD3E Heterodimer Protein, Mouse (HEK293) P04235 (F22-A105)&P22646 (D22-D108) ≥95%
HY-P77614 CD3D-CD3E Heterodimer Protein, Mouse (HEK293, Fc) P04235 (F22-A105)&P22646 (D23-D108) ≥95%

相关产品

Approval
抗体抑制剂 (2)
目录号 产品名 作用方式
纯度 是否罕见病
HY-P9963 Blinatumomab Inhibitor 98.78% 否
HY-P99909 Elranatamab 97% 否
Clinical Phase
抗体抑制剂 (6)
目录号 产品名 作用方式
纯度 Phase
HY-P99332 Visilizumab Inducer 98.48% Phase 3
HY-P990688 Xaluritamig Inhibitor 98.00% Phase 3
HY-P990717 Brenetafusp Inhibitor / Phase 3
HY-P99896 Runimotamab 99.00% Phase 1
HY-P99868 Duvortuxizumab ≥99.0% Phase 1
HY-P99798 Pacanalotamab Chemical 97.04% Phase 1
Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS02243 CD3E Human Pre-designed siRNA Set A Pre-designed Sets / 否
抗体抑制剂 (22)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-P990095 Vonsetamig Inhibitor 95.00% 否
HY-P990903 Avitotamig Inhibitor / 否
HY-P990920 Gocatamig Inhibitor / 否
HY-P990925 Linclatamig Inhibitor / 否
HY-P990928 Mipletamig Inhibitor / 否
HY-P990932 Obrixtamig Inhibitor / 否
HY-P990939 Podentamig Inhibitor / 否
HY-P990953 Zubotamig Inhibitor / 否
HY-P990955 Ebribafusp alfa Inhibitor / 否
HY-P990969 Amtabafusp alfa Inhibitor / 否
HY-P991015 Pasritamig Inhibitor / 否
HY-P991028 Surovatamig Inhibitor / 否
HY-P991034 Trevotamig Inhibitor / 否
HY-P991036 Velinotamig Inhibitor / 否
HY-P99914 Emfizatamab / 否
HY-P99916 Emirodatamab / 否
HY-P990692 Ciduvectamig Inhibitor / 否
HY-P990698 Umizortamig / 否
HY-P990714 Obertamig Inhibitor / 否
HY-P990759 Rezetamig / 否
HY-P99948 Etevritamab / 否
HY-P991044 Anti-Mouse CD3E Antibody (1E11.D) Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Cd3e NCBI NCBI:916
Canis familiaris Cd3e NCBI NCBI:442981
Macaca fascicularis Cd3e NCBI NCBI:102133065
Rattus norvegicus Cd3e NCBI NCBI:315609
Macaca mulatta Cd3e NCBI NCBI:699467
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