2. Gene
  3. Cd44 - CD44 antigen Gene

Cd44 - CD44 antigen Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Ly-24; Pgp-1; HERMES

基因 ID: 12505 | 基因类型: protein coding

关于 Cd44

功能概要

Enables hyaluronic acid binding activity and type II transforming growth factor beta receptor binding activity. Contributes to cytokine binding activity and cytokine receptor activity. Involved in several processes, including negative regulation of T cell activation; positive regulation of protein phosphorylation; and regulation of intracellular signal transduction. Acts upstream of or within several processes, including Wnt signaling pathway; morphogenesis of a branching epithelium; and wound healing involved in inflammatory response. Located in basolateral plasma membrane; external side of plasma membrane; and microvillus. Part of macrophage migration inhibitory factor receptor complex. Is expressed in several structures, including alimentary system; branchial arch; central nervous system; genitourinary system; and limb. Human ortholog(s) of this gene implicated in breast carcinoma (multiple); carcinoma (multiple); and prostate Cancer. Orthologous to human CD44 (CD44 molecule (Indian blood group)). [provided by Alliance of Genome Resources, Apr 2022]

Cd44 基因产物(6)

mRNA Protein Name
NM_001039150.1 NP_001034239.1 CD44 antigen isoform b precursor
NM_001039151.1 NP_001034240.1 CD44 antigen isoform c precursor
NM_001177785.1 NP_001171256.1 CD44 antigen isoform d precursor
NM_001177786.1 NP_001171257.1 CD44 antigen isoform e precursor
NM_001177787.1 NP_001171258.1 CD44 antigen isoform f precursor
NM_009851.2 NP_033981.2 CD44 antigen isoform a precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables cargo receptor activity IDA
IDA: 通过直接分析推断
1703543 MGI
enables cargo receptor activity IMP
IMP: 通过突变表型推断
26528478 MGI
contributes to cytokine binding IDA
IDA: 通过直接分析推断
18056708 MGI
contributes to cytokine receptor activity IDA
IDA: 通过直接分析推断
17045821 MGI
enables hyaluronic acid binding IMP
IMP: 通过突变表型推断
10926769 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
7535771 MGI
enables type II transforming growth factor beta receptor binding IPI
IPI: 通过物理相互作用推断
25065622 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within Wnt signaling pathway IDA
IDA: 通过直接分析推断
19056892 MGI
acts upstream of or within branching involved in prostate gland morphogenesis IMP
IMP: 通过突变表型推断
9374396 MGI
acts upstream of or within branching involved in ureteric bud morphogenesis IMP
IMP: 通过突变表型推断
10926769 MGI
involved in hyaluronan catabolic process IDA
IDA: 通过直接分析推断
26528478 MGI
involved in hyaluronan catabolic process IMP
IMP: 通过突变表型推断
26528478 MGI
involved in negative regulation of CD4-positive, alpha-beta T cell proliferation IMP
IMP: 通过突变表型推断
25065622 MGI
involved in negative regulation of DNA damage response, signal transduction by p53 class mediator IMP
IMP: 通过突变表型推断
17045821 MGI
involved in negative regulation of inflammatory response IMP
IMP: 通过突变表型推断
25065622 MGI
involved in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IMP
IMP: 通过突变表型推断
17045821 MGI
involved in negative regulation of mature B cell apoptotic process IDA
IDA: 通过直接分析推断
18056708 MGI
involved in negative regulation of regulatory T cell differentiation IMP
IMP: 通过突变表型推断
25065622 MGI
involved in positive regulation of ERK1 and ERK2 cascade IMP
IMP: 通过突变表型推断
17045821 MGI
acts upstream of or within positive regulation of gene expression IGI
IGI: 通过遗传相互作用推断
9847236 MGI
involved in receptor-mediated endocytosis IDA
IDA: 通过直接分析推断
26528478 MGI
involved in receptor-mediated endocytosis IMP
IMP: 通过突变表型推断
26528478 MGI
acts upstream of or within wound healing involved in inflammatory response IMP
IMP: 通过突变表型推断
11935029 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in basolateral plasma membrane IDA
IDA: 通过直接分析推断
10027409 MGI
located in cell surface IDA
IDA: 通过直接分析推断
9324354 MGI
located in external side of plasma membrane IDA
IDA: 通过直接分析推断
7538697 MGI
part of macrophage migration inhibitory factor receptor complex IDA
IDA: 通过直接分析推断
17045821 MGI
located in microvillus IDA
IDA: 通过直接分析推断
9472040 MGI
located in plasma membrane IDA
IDA: 通过直接分析推断
9374396 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

CD44 antigen

ECMR-III

GP90 lymphocyte homing/adhesion receptor

HUTCH-I

PGP-I

extracellular matrix receptor III

hermes antigen

hyaluronate receptor

lymphocyte antigen 24

phagocytic glycoprotein 1

phagocytic glycoprotein I

重组 Cd44 蛋白

目录号 产品名 蛋白编号 纯度
HY-P74291 CD44 Protein, Mouse (HEK293, His) NP_001034240.1 (Q25-T224) ≥95%

相关产品

Pre-clinical Phase
生物活性分子 (11)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-P2230 Angstrom6 Inhibitor 99.01% 否
HY-149898 HA-CD44 interaction inhibitor 1 Inhibitor 98.93% 否
HY-149897 HA-CD44 interaction inhibitor 2 99.04% 否
HY-RS02248 CD44 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-100914 A-7 hydrochloride Antagonist 99.09% 否
HY-143491 VS 8 / 否
HY-148918 E722-2648 Inhibitor / 否
HY-156096 HDAC3-IN-2 / 否
HY-E70290 N-Acetylgalactosaminyltransferase 1 Agonist / 否
HY-122585 proMMP-9 inhibitor-3c Inhibitor / 否
HY-164480 GTCpFE Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Cd44 NCBI NCBI:960
Macaca fascicularis Cd44 NCBI NCBI:101867504
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