2. Gene
  3. Cdk11b - cyclin-dependent kinase 11B Gene

Cdk11b - cyclin-dependent kinase 11B Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：细胞周期蛋白依赖性激酶 11B

种属: Mus musculus

同用名: p58; Cdk11; Cdc11b; Cdc2l1; Cdc2l2; CDK11-p46; CDK11-p58; CDK11-p110

基因 ID: 12537 | 基因类型: protein coding

关于 Cdk11b

Chromosome 4: 155,709,311-155,734,395 forward strand.GRCm39:CM000997.3

This gene has 8 transcripts (splice variants), 203 orthologues, 25 paralogues and is associated with 8 phenotypes. Ubiquitous expression in CNS E11.5 (RPKM 24.), large intestine adult (RPKM 15.5) and 28 other tissues.

功能概要

预计该基因编码的蛋白可启动 ATP 结合活性和细胞周期蛋白依赖性蛋白丝氨酸/苏氨酸激酶活性。作用于胚泡发育的上游或内部；凋亡信号通路的负调控；和有丝分裂核分裂的调节。位于核内。以多种结构表达，包括消化系统；胚泡;脑;早期胚胎；和外皮系统。与几个人类基因同源，包括 CDK11B（细胞周期蛋白依赖性激酶 11B）。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable ATP binding activity and cyclin-dependent protein serine/threonine kinase activity. Acts upstream of or within blastocyst development; negative regulation of apoptotic signaling pathway; and regulation of mitotic nuclear division. Located in nucleus. Is expressed in several structures, including alimentary system; blastocyst; brain; early embryo; and integumental system. Orthologous to several human genes including CDK11B (cyclin dependent kinase 11B). [provided by Alliance of Genome Resources, Apr 2022]

Cdk11b 基因产物(5)

mRNA Protein Name
NM_001347308.1 NP_001334237.1 cyclin-dependent kinase 11B isoform 2
NM_001355568.1 NP_001342497.1 cyclin-dependent kinase 11B isoform 2
NM_001355569.1 NP_001342498.1 cyclin-dependent kinase 11B isoform 4
NM_007661.4 NP_031687.2 cyclin-dependent kinase 11B isoform 1
NM_001355567.1 NP_001342496.1 cyclin-dependent kinase 11B isoform 3
基因本体论
  • 生物过程
  • 细胞组分
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within blastocyst development IMP
IMP: 通过突变表型推断
15060143 MGI
acts upstream of or within negative regulation of apoptotic signaling pathway IMP
IMP: 通过突变表型推断
15060143 MGI
acts upstream of or within regulation of mitotic nuclear division IMP
IMP: 通过突变表型推断
15060143 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nucleus IDA
IDA: 通过直接分析推断
15060143 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Cdk11b 蛋白结构

STKc_CDC2L1

STKc_CDC2L1: cd07843 (420 - 711)

  • 0
  • 200
  • 400
  • 600
  • 784 a.a.
蛋白主名 其他名称

cyclin-dependent kinase 11B

PITSLRE proteins

PITSLRE serine/threonine-protein kinase CDC2L1

cell division cycle 2 homolog-like 1

cell division cycle 2 homolog-like 2

cell division cycle 2-like 1

cell division cycle 2-like 2

cell division cycle 2-like protein kinase 1

cell division protein kinase 11

cyclin-dependent kinase 11

galactosyltransferase-associated protein kinase p58/GTA

相关产品

Pre-clinical Phase
生物活性分子 (8)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-12467 OTS964 hydrochloride 99.74% 否
HY-148063 DB0614 98.80% 否
HY-155874 ZNL-05-044 Inhibitor 99.91% 否
HY-148061 DB1113 99.28% 否
HY-19718 OTS964 / 否
HY-RS02353 CDK11B Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS02354 Cdk11b Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS02355 Cdk11b Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Cdk11b NCBI NCBI:984
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