ADH4 - alcohol dehydrogenase 4 (class II), pi polypeptide Gene

中文名称：醇脱氢酶 4 (II 类) ，pi 多肽

种属: Homo sapiens

同用名: ADH-2; HEL-S-4

基因 ID: 127 | 基因类型: protein coding

关于 ADH4

Cytogenetic location: 4q23 Genomic coordinates (GRCh38): 4:99,123,658-99,144,297 (from NCBI)

This gene has 11 transcripts (splice variants), 346 orthologues and 17 paralogues. Restricted expression toward liver (RPKM 940.8).

功能概要

该基因编码 II 类醇脱氢酶 4 pi 亚基，它是醇脱氢酶家族的成员。该酶家族的成员代谢多种底物，包括乙醇、视黄醇、其他脂肪醇、羟基类固醇和脂质过氧化产物。 II 类醇脱氢酶是由 2 个 pi 亚基组成的同型二聚体。它对长链脂肪醇和芳香醇表现出高氧化活性，对吡唑不太敏感。该基因定位于乙醇脱氢酶基因簇中的 4 号染色体。[RefSeq 提供，2008 年 7 月]

This gene encodes class II alcohol dehydrogenase 4 pi subunit, which is a member of the alcohol dehydrogenase family. Members of this Enzyme family metabolize a wide variety of substrates, including ethanol, retinol, Other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. Class II alcohol dehydrogenase is a homodimer composed of 2 pi subunits. It exhibits a high activity for oxidation of long-chain aliphatic alcohols and aromatic alcohols and is less sensitive to pyrazole. This gene is localized to chromosome 4 in the cluster of alcohol dehydrogenase genes. [provided by RefSeq, Jul 2008]

ADH4 基因产物(3)

mRNA	Protein	Name
NM_000670.5	NP_000661.2	all-trans-retinol dehydrogenase [NAD(+)] ADH4 isoform 2
NM_001306171.2	NP_001293100.1	all-trans-retinol dehydrogenase [NAD(+)] ADH4 isoform 1
NM_001306172.2	NP_001293101.1	all-trans-retinol dehydrogenase [NAD(+)] ADH4 isoform 1

基因本体论

分子功能
生物过程

分子功能 GO 注释	逻辑证据	参考文献	来源
enables NAD binding	IDA IDA: 通过直接分析推断	10407146	GOA
enables alcohol dehydrogenase (NAD+) activity	IDA IDA: 通过直接分析推断	3466164	GOA
enables all-trans retinal binding	IDA IDA: 通过直接分析推断	15369820	GOA
enables all-trans-retinol dehydrogenase (NAD+) activity	IDA IDA: 通过直接分析推断	10514444	GOA
enables benzaldehyde dehydrogenase (NAD+) activity	IDA IDA: 通过直接分析推断	3466164	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	32296183	GOA
enables retinol binding	IDA IDA: 通过直接分析推断	10407146	GOA
enables zinc ion binding	IDA IDA: 通过直接分析推断	10407146	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in alcohol metabolic process	IDA IDA: 通过直接分析推断	3466164	GOA
involved in cellular aldehyde metabolic process	IDA IDA: 通过直接分析推断	3466164	GOA
involved in fatty acid omega-oxidation	IDA IDA: 通过直接分析推断	16081420	GOA
involved in retinoid metabolic process	IDA IDA: 通过直接分析推断	15369820	GOA
involved in retinol metabolic process	IDA IDA: 通过直接分析推断	16787387	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ADH4 蛋白结构

ADH_N

ADH_zinc_N

0
100
200
300
380 a.a.

蛋白主名

其他名称

all-trans-retinol dehydrogenase [NAD(+)] ADH4

alcohol dehydrogenase class II pi chain

ADH4 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	ADH4	P08319	TRIM69	Homo sapiens	Q86WT6-2	Validated Y2H	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Alcohol Dependence

Alcoholism	Alcohol Dependence, Susceptibility To
Alcohol Dependence, Protection Against	Aerodigestive Tract Cancer, Squamous Cell, Alcohol-Related, Protection Against
Alcoholism, Susceptibility To	Alcoholic Intoxication, Chronic
Pharyngeal Neoplasms	Chronic Alcoholism
Dipsomania	Alcohol Addiction
Ethanol Dependence	Chronic Ethanolism
Chronic Alcoholic Disease Nos	Alcoholic Disease Nos
Alcoholic

Alcohol-Related Birth Defects

Arbd	Alcohol-Related Birth Defect
Alcohol Related Birth Defect	Fetal Alcohol Syndrome

Cluster Headache

Headache, Cluster

Hypocalciuric Hypercalcemia, Familial, Type Ii

HHC2	Familial Hypocalciuric Hypercalcemia 2
Fbh2	Familial Hypocalciuric Hypercalcemia Type 2
Hypocalciuric Hypercalcemia, Type Ii	Fhh Type 2
Familial Benign Hypercalcemia, Type Ii	Hypercalcemia, Familial Benign, Type Ii
Hypocalciuric Hypercalcemia Type Ii	Familial Benign Hypercalcemia, Type 2
Hypercalcemia, Familial Benign Type 2	Hypocalciuric Hypercalcemia, Familial, Type 2
Hypocalciuric Hypercalcemia, Familial 2	Familial Benign Hypercalcemia Type Ii
Hypocalciuric Hypercalcemia-2

Hypocalciuric Hypercalcemia, Familial, Type I

HHC1	Familial Hypocalciuric Hypercalcemia 1
Fhh1	Familial Benign Hypercalcemia 1
Fbh1	Hypocalciuric Hypercalcemia, Type I
Fhh Type 1	Hhc
Fhh	Hypercalcemia, Familial Benign
Hypocalciuric Hypercalcemia Type I	Familial Hypocalciuric Hypercalcemia Type 1
Hypocalciuric Hypercalcemia, Familial, Type 1	Familial Hypocalciuric Hypercalcemia Type I
Familial Benign Hypercalcemia Type 1	Hypercalcemia, Familial Benign Type 1
Hypocalciuric Hypercalcemia, Familial 1	Familial Benign Hypocalciuric Hypercalcemia 1
Fbhh1

Substance Dependence

Familial Hypocalciuric Hypercalcemia

Familial Benign Hypercalcemia	Fbh
Fbhh	Fhh
Familial Benign Hypocalciuric Hypercalcemia	Hypocalciuric Hypercalcemia, Familial, Type 1

Headache

Headache Disorder

Hypocalcemia, Autosomal Dominant 1

Autosomal Dominant Hypocalcemia	Autosomal Dominant Hypocalcemia 1
HYPOC1	Hypocalcemia, Autosomal Dominant
Hypercalciuric Hypocalcemia	Hypocalcemia, Autosomal Dominant, With Bartter Syndrome
Familial Hypocalcemia	Hypocalcemia, Familial
Hypoc	Adh
Autosomal Dominant Hypoparathyroidism	Familial Hypercalciuric Hypocalcemia
Ad Hypocalcemia	Autosomal Dominant Hypocalcemia With Bartter Syndrome
Hypoparathyroidism - Autosomal Dominant	Hypocalcemia

Familial Isolated Hypoparathyroidism

Fih

Fetal Alcohol Spectrum Disorder

Fetal Alcohol Spectrum Disorders

Fetal Alcohol Syndrome

Fetal Alcohol Spectrum Disorders	Arbd
Arnd	Alcohol-Related Birth Defects
Alcohol-Related Neurodevelopmental Disorder	Fas
Fasd	Fetus Or Newborn Affected By Alcohol Transmitted Via Placenta Or Breast Milk
Alcohol Related Birth Defect	Alcohol Related Neurodevelopmental Disorder
Alcohol Affecting Fetus Or Newborn Via Placenta Or Breast Milk	Fetus Or Newborn Affected By Alcohol Transmitted Via Placenta And/Or Breast Milk
Dysmorphism Due To Alcohol	Fetal Etoh Syndrome

Alcohol Use Disorder

Alcohol Abuse	Alcoholism
Ethanol Abuse	Alcohol Addiction
Alcohol Dependence	Alcoholic Intoxication, Chronic
Alcohol-Related Disorders

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS00369	ADH4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	ADH4	RGD	RGD:71028
Mus musculus	ADH4	MGD	MGI:1349472

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站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

ADH4 - alcohol dehydrogenase 4 (class II), pi polypeptide Gene

关于 ADH4

功能概要

ADH4 基因产物(3)

ADH4 蛋白结构

ADH4 蛋白互作信息

关联疾病

直系同源

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ADH4 - alcohol dehydrogenase 4 (class II), pi polypeptide Gene

关于 ADH4

功能概要

ADH4 基因产物(3)

ADH4 蛋白结构

ADH4 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

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B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z