IQGAP3 - IQ motif containing GTPase activating protein 3 Gene

中文名称：含 IQ 基序的 GTPase 激活蛋白 3

种属: Homo sapiens

基因 ID: 128239 | 基因类型: protein coding

关于 IQGAP3

This gene has 4 transcripts (splice variants), 213 orthologues and 2 paralogues. Broad expression in bone marrow (RPKM 5.6), duodenum (RPKM 3.0) and 16 other tissues.

功能概要

启用钙调蛋白结合活性和肌球蛋白 VI 轻链结合活性。预计参与肌动蛋白细胞骨架组织的调节。预计在多个过程的上游或内部起作用，包括细胞内信号转导；大分子代谢过程的正向调控；和乳腺上皮细胞增殖的正调节。预测位于胞质溶胶中。预计在细胞质中有活性。 [由基因组资源联盟提供，2022 年 4 月]

Enables Calmodulin binding activity and Myosin VI light chain binding activity. Predicted to be involved in regulation of actin Cytoskeleton organization. Predicted to act upstream of or within several processes, including intracellular signal transduction; positive regulation of macromolecule metabolic process; and positive regulation of mammary gland epithelial cell proliferation. Predicted to be located in cytosol. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

IQGAP3 基因产物(1)

mRNA	Protein	Name
NM_178229.5	NP_839943.3	ras GTPase-activating-like protein IQGAP3

基因本体论

分子功能

分子功能 GO 注释	逻辑证据	参考文献	来源
enables calmodulin binding	IPI IPI: 通过物理相互作用推断	21299499	GOA
enables myosin VI light chain binding	IPI IPI: 通过物理相互作用推断	21299499	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	32814053	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

IQGAP3 蛋白结构

RasGAP

RasGAP_C

0
300
600
900
1200
1500
1631 a.a.

蛋白主名

其他名称

ras GTPase-activating-like protein IQGAP3

IQGAP3 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	IQGAP3	Q86VI3	GSN	Homo sapiens	P06396	Y2H Array	32814053
种属内	IQGAP3	Q86VI3	GSN	Homo sapiens	P06396	Y2H Pooling	32814053
种属内	IQGAP3	Q86VI3	GSN	Homo sapiens	P06396	Validated Y2H	32814053

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Lung Papillary Adenocarcinoma

Papillary Lung Adenocarcinoma

Papillary Adenocarcinoma Of The Lung

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS06887	IQGAP3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	IQGAP3	VGNC	VGNC:53495
Bos taurus	IQGAP3	VGNC	VGNC:30260
Rattus norvegicus	IQGAP3	RGD	RGD:1305951
Felis catus	IQGAP3	VGNC	VGNC:62966
Macaca mulatta	IQGAP3	VGNC	VGNC:73634
Mus musculus	IQGAP3	MGD	MGI:3028642

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

IQGAP3 - IQ motif containing GTPase activating protein 3 Gene

关于 IQGAP3

功能概要

IQGAP3 基因产物(1)

IQGAP3 蛋白结构

IQGAP3 蛋白互作信息

关联疾病

直系同源

热门区域

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IQGAP3 - IQ motif containing GTPase activating protein 3 Gene

关于 IQGAP3

功能概要

IQGAP3 基因产物(1)

IQGAP3 蛋白结构

IQGAP3 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

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B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z