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  2. AADAC - arylacetamide deacetylase Gene

AADAC - arylacetamide deacetylase Gene

中文名称:芳基乙酰胺脱乙酰酶

种属: Homo sapiens

同用名: DAC; CES5A1

基因 ID: 13 | 基因类型: protein coding

关于 AADAC

Cytogenetic location: 3q25.1 Genomic coordinates (GRCh38): 3:151,814,116-151,828,488 (from NCBI)

This gene has 2 transcripts (splice variants), 214 orthologues and 5 paralogues. Biased expression in liver (RPKM 174.6), small intestine (RPKM 100.2) and 4 other tissues.

功能概要

微粒体芳基乙酰胺脱乙酰酶与细胞溶质芳胺 N-乙酰转移酶的活性竞争,后者催化芳胺和杂环胺致癌物的初始生物转化途径之一[RefSeq 提供,2008 年 7 月]

Microsomal arylacetamide deacetylase competes against the activity of cytosolic arylamine N-acetyltransferase, which catalyzes one of the initial biotransformation pathways for arylamine and heterocyclic amine carcinogens [provided by RefSeq, Jul 2008]

AADAC 基因产物(1)

mRNA Protein Name
NM_001086.3 NP_001077.2 arylacetamide deacetylase
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables deacetylase activity IDA
IDA: 通过直接分析推断
9665742 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
enables serine hydrolase activity IDA
IDA: 通过直接分析推断
17936933 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in endoplasmic reticulum membrane IDA
IDA: 通过直接分析推断
10318829 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

AADAC 蛋白结构

Abhydrolase_3

Abhydrolase_3: alpha/beta hydrolase fold (107 - 259)

Abhydrolase_3

Abhydrolase_3: alpha/beta hydrolase fold (316 - 376)

  • 0
  • 100
  • 200
  • 300
  • 399 a.a.
蛋白主名 其他名称

arylacetamide deacetylase

arylacetamide deacetylase (esterase)

AADAC 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
AADAC P22760 APPBP2 Homo sapiens Q92624
Y2H Prey Pooling
32296183
种属内
AADAC P22760 APPBP2 Homo sapiens Q92624
Validated Y2H
32296183
种属内
AADAC P22760 APPBP2 Homo sapiens Q92624
Y2H Array
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 AADAC 蛋白

目录号 产品名 蛋白编号 纯度
HY-P72067 AADAC Protein, Human (His-SUMO) P22760 (P24-L399) ≥95%

关联疾病

疾病名称 别名
Chronic Tic Disorder

Chronic Motor Or Vocal Tic Disorder

Tic Disorders

Tic Disorder

Tic Disorder Nos

Tic Nos

Tic Spasm Nos

Tic Disorder

Tics

Behavioral Tic

Gilles De La Tourette Syndrome

Tourette Syndrome

Tourette Disorder

GTS

Ts

Gilles De La Tourette'S Syndrome

Motor-Verbal Tic Disorder

Guinon'S Disease

Psychogenic Tics

Tourette'S Syndrome

Chronic Motor And Vocal Tic Disorder

Td

Tourette'S Disease

Combined Vocal And Multiple Motor Tic Disorder [De La Tourette]

Combined Vocal And Multiple Motor Tic Disorder

Tic De La Tourette

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta AADAC VGNC VGNC:81172
Mus musculus AADAC MGD MGI:1915008
Canis familiaris AADAC VGNC VGNC:37404
Rattus norvegicus AADAC RGD RGD:631440
Others AADAC NCBI