ACMSD - aminocarboxymuconate semialdehyde decarboxylase Gene

中文名称：氨基羧基粘康酸半醛脱羧酶

种属: Homo sapiens

基因 ID: 130013 | 基因类型: protein coding

关于 ACMSD

Cytogenetic location: 2q21.3 Genomic coordinates (GRCh38): 2:134,838,616-134,902,034 (from NCBI)

This gene has 4 transcripts (splice variants) and 199 orthologues. Biased expression in kidney (RPKM 17.3), liver (RPKM 10.7) and 1 other tissue.

功能概要

神经元兴奋毒素喹啉酸盐是色氨酸从头合成 NAD 途径中的中间体，与多种神经退行性疾病的发病机制有关。喹啉酸盐衍生自 α-氨基-β-羧基-粘康酸盐-ε-半醛 (ACMS) 。 ACMSD (ACMS 脱羧酶；EC 4.1.1.45) 可以将 ACMS 转化为良性分解代谢物，从而防止 ACMS 中喹啉酸盐的积累。[OMIM 提供，2004 年 10 月]

The neuronal excitotoxin quinolinate is an intermediate in the de novo synthesis pathway of NAD from tryptophan, and has been implicated in the pathogenesis of several neurodegenerative disorders. Quinolinate is derived from alpha-amino-beta-carboxy-muconate-epsilon-semialdehyde (ACMS). ACMSD (ACMS decarboxylase; EC 4.1.1.45) can divert ACMS to a benign catabolite and thus prevent the accumulation of quinolinate from ACMS.[supplied by OMIM, Oct 2004]

ACMSD 基因产物(2)

mRNA	Protein	Name
NM_001307983.2	NP_001294912.1	2-amino-3-carboxymuconate-6-semialdehyde decarboxylase isoform 2
NM_138326.3	NP_612199.2	2-amino-3-carboxymuconate-6-semialdehyde decarboxylase isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
NOT enables aminocarboxymuconate-semialdehyde decarboxylase activity	IDA IDA: 通过直接分析推断	17288562	GOA
enables aminocarboxymuconate-semialdehyde decarboxylase activity	IDA IDA: 通过直接分析推断	12140278	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	25416956	GOA
enables zinc ion binding	IDA IDA: 通过直接分析推断	19843166	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in negative regulation of quinolinate biosynthetic process	IDA IDA: 通过直接分析推断	12140278	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cytosol	IDA IDA: 通过直接分析推断	12140278	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ACMSD 蛋白结构

Amidohydro_2

0
100
200
300
336 a.a.

蛋白主名

其他名称

2-amino-3-carboxymuconate-6-semialdehyde decarboxylase

picolinate carboxylase

ACMSD 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	ACMSD	Q8TDX5	MAGEA11	Homo sapiens	P43364-2	Validated Y2H	25416956

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Pellagra

Niacin Deficiency	Niacin-Tryptophan Deficiency
Pellagroid Syndrome

Hydroxykynureninuria

Xanthurenic Aciduria	Kynureninase Deficiency
Kynureninase Deficiency, Partial	HYXKY
Partial Kynureninase Deficiency

Epilepsy, Familial Adult Myoclonic, 2

FAME2	Benign Adult Familial Myoclonic Epilepsy 2
Bafme2	Fcmte2
Adcme	Cortical Myoclonic Tremor With Epilepsy, Familial, 2
Cortical Myoclonus And Epilepsy, Autosomal Dominant	Familial Adult Myoclonic Epilepsy 2
Epilepsy, Myoclonic, Benign Adult Familial, Type 2	Autosomal Dominant Cortical Myoclonus And Epilepsy
Familial Cortical Myoclonic Tremor And Epilepsy 2	Epilepsy, Myoclonic, Familial Adult, Type 2

Epilepsy, Familial Adult Myoclonic, 5

FAME5	Fcmte5
Cortical Myoclonic Tremor With Epilepsy, Familial, 5	Familial Adult Myoclonic Epilepsy 5
Epilepsy, Myoclonic, Familial Adult, 5	Familial Cortical Myoclonic Tremor And Epilepsy 5
Familial Cortical Myoclonic Tremor With Epilepsy 5	Epilepsy, Myoclonic, Familial Adult, Type 5

Familial Adult Myoclonic Epilepsy

Benign Adult Familial Myoclonus Epilepsy	Bafme
Benign Adult Familial Myoclonic Epilepsy	Fame
Familial Cortical Myoclonic Tremor And Epilepsy	Fcmte
Adcme	Autosomal Dominant Cortical Myoclonus And Epilepsy
Fam	Epilepsy, Myoclonic, Familial Adult
Epilepsy, Myoclonic, Benign Adult Familial, Type 2

Parkinson Disease, Late-Onset

Parkinson Disease	Parkinson'S Disease
PD	PARK
Parkinson Disease, Susceptibility To	Late Onset Parkinson'S Disease
Late Onset Parkinson Disease	Paralysis Agitans
Primary Parkinsonism	Idiopathic Parkinson Disease
Parkinson'S	Parkinson Disease, Late-Onset, Susceptibility To
Parkinson Disease, Age Of Onset, Modifier	Lewy Body Parkinson Disease
Idiopathic Parkinson'S Disease	Pd - [Parkinson Disease]
Parkinson Disease Nos	Parkinson, Nos
Primary Parkinson Disease

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-111365	TES-1025	Inhibitor	98.12%	否
HY-112619	TES-991	Inhibitor	99.65%	否
HY-RS00169	ACMSD Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	ACMSD	MGD	MGI:2386323
Bos taurus	ACMSD	VGNC	VGNC:25544
Canis familiaris	ACMSD	VGNC	VGNC:37512
Felis catus	ACMSD	VGNC	VGNC:59514
Rattus norvegicus	ACMSD	RGD	RGD:620868
Macaca mulatta	ACMSD	VGNC	VGNC:69476

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。	站点地图隐私声明
沪ICP备15051369号-4 上海工商沪公网安备31011502019417 沪(浦)应急管危经许[2021]201709(QFYS) 营业执照（三证合一）
Copyright © 2013-2025 MedChemExpress. All Rights Reserved.

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

ACMSD - aminocarboxymuconate semialdehyde decarboxylase Gene

关于 ACMSD

功能概要

ACMSD 基因产物(2)

ACMSD 蛋白结构

ACMSD 蛋白互作信息

关联疾病

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

姓名
邮箱 *

Sorry, but the email address you supplied was invalid.

ACMSD - aminocarboxymuconate semialdehyde decarboxylase Gene

关于 ACMSD

功能概要

ACMSD 基因产物(2)

ACMSD 蛋白结构

ACMSD 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z