COPA - COPI coat complex subunit alpha Gene

中文名称：COPI 外壳复杂亚基 alpha

种属: Homo sapiens

同用名: AILJK; HEP-COP; alpha-COP

关于 COPA

功能概要

在真核细胞中，内质网和高尔基体之间的蛋白质转运部分由非网格蛋白包被的囊泡外壳蛋白 (COP) 介导。已经鉴定出七种外壳蛋白，它们代表称为外壳体的复合物的亚基。这些亚基被命名为 alpha-COP、beta-COP、beta-prime-COP、gamma-COP、delta-COP、epsilon-COP 和 zeta-COP。由 COPA 编码的 alpha-COP 与酵母中 coatomer 复合体的 alpha 亚基 RET1P 具有高度序列相似性。此外，α-COP 的 N 端 25 个氨基酸编码生物活性肽 xenin，它可刺激胰腺外分泌并可作为胃肠激素。可变剪接导致编码不同亚型的多种剪接形式。[RefSeq 提供，2008 年 7 月]

In eukaryotic cells, protein transport between the endoplasmic reticulum and Golgi compartments is mediated in part by non-clathrin-coated vesicular coat proteins (COPs). Seven coat proteins have been identified, and they represent subunits of a complex known as coatomer. The subunits are designated alpha-COP, beta-COP, beta-prime-COP, gamma-COP, delta-COP, epsilon-COP, and zeta-COP. The alpha-COP, encoded by COPA, shares high sequence similarity with RET1P, the alpha subunit of the coatomer complex in yeast. Also, the N-terminal 25 Amino acids of alpha-COP encode the bioactive peptide, xenin, which stimulates exocrine pancreatic secretion and may act as a gastrointestinal hormone. Alternative splicing results in multiple splice forms encoding distinct isoforms. [provided by RefSeq, Jul 2008]