SLC31A1 - solute carrier family 31 member 1 Gene

中文名称：溶质载体家族 31 成员 1

种属: Homo sapiens

同用名: CTR1; COPT1

基因 ID: 1317 | 基因类型: protein coding

关于 SLC31A1

Cytogenetic location: 9q32 Genomic coordinates (GRCh38): 9:113,221,544-113,264,492 (from NCBI)

This gene has 2 transcripts (splice variants), 215 orthologues, 1 paralogue and is associated with 1 phenotype. Ubiquitous expression in liver (RPKM 33.0), duodenum (RPKM 22.8) and 25 other tissues.

功能概要

该基因编码的蛋白质是一种存在于细胞膜中的高亲和力铜转运蛋白。编码的蛋白质起到同源三聚体的作用，影响膳食铜的吸收。[RefSeq 提供，2011 年 8 月]

The protein encoded by this gene is a high-affinity copper transporter found in the cell membrane. The encoded protein functions as a homotrimer to effect the uptake of dietary copper. [provided by RefSeq, Aug 2011]

SLC31A1 基因产物(1)

mRNA	Protein	Name
NM_001859.4	NP_001850.1	high affinity copper uptake protein 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables copper ion binding	IDA IDA: 通过直接分析推断	26745413	GOA
enables copper ion transmembrane transporter activity	IDA IDA: 通过直接分析推断	11734551	GOA
enables identical protein binding	IPI IPI: 通过物理相互作用推断	16501047	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	24837030	GOA
enables silver ion transmembrane transporter activity	IDA IDA: 通过直接分析推断	20569931	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in angiogenesis	IMP IMP: 通过突变表型推断	35027734	GOA
involved in copper ion import	IDA IDA: 通过直接分析推断	16135512	GOA
involved in plasma membrane copper ion transport	IDA IDA: 通过直接分析推断	11734551	GOA
involved in protein complex oligomerization	IDA IDA: 通过直接分析推断	15326162	GOA
involved in silver ion transmembrane transport	IDA IDA: 通过直接分析推断	20569931	GOA
involved in vascular endothelial growth factor receptor-2 signaling pathway	IMP IMP: 通过突变表型推断	35027734	GOA
involved in xenobiotic transport	IDA IDA: 通过直接分析推断	20451502	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in early endosome membrane	IDA IDA: 通过直接分析推断	26945057	GOA
located in plasma membrane	IDA IDA: 通过直接分析推断	11734551	GOA
located in recycling endosome membrane	IDA IDA: 通过直接分析推断	26945057	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SLC31A1 蛋白结构

Ctr

0
100
190 a.a.

蛋白主名

其他名称

high affinity copper uptake protein 1

copper transport 1 homolog

SLC31A1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	SLC31A1	O15431	SLC31A1	Homo sapiens	O15431	GMS	16501047
种属内	SLC31A1	O15431	ABHD18	Homo sapiens	Q0P651	Anti Tag CoIP	33961781
种属内	SLC31A1	O15431	SLC31A1	Homo sapiens	O15431	GMS	19240214
种属内	SLC31A1	O15431	SLC31A1	Homo sapiens	O15431	3D-EM	19240214
种属内	SLC31A1	O15431	NCR3LG1	Homo sapiens	Q68D85	Anti Tag CoIP	33961781
种属内	SLC31A1	O15431	SLC31A1	Homo sapiens	O15431	3D-EM	16501047
种属内	SLC31A1	O15431	SLC31A1	Homo sapiens	O15431	Crosslink	19240214
种属内	SLC31A1	O15431	SLC31A1	Homo sapiens	O15431	Crosslink	16501047
种属内	SLC31A1	O15431	ABCB8	Homo sapiens	Q9NUT2	Anti Tag CoIP	33961781
种属内	SLC31A1	O15431	ACAD10	Homo sapiens	Q6JQN1	Anti Tag CoIP	33961781

种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 SLC31A1 蛋白

目录号	产品名	蛋白编号	纯度
HY-P72011	SLC31A1 Protein, Human (Cell-Free, His-SUMO)	O15431 (M1-H190)	≥95%

关联疾病

疾病名称

别名

Wilson Disease

Hepatolenticular Degeneration	WD
Wilson'S Disease	WND
Westphal-Strumpell Syndrome	Copper Storage Disease
Cerebral Pseudosclerosis	Westphal Pseudosclerosis
Hepatolenticular Degeneration Syndrome	Copper Retention
Hepatocerebral Degeneration	Kinnier-Wilson Disease
Neurohepatic Degeneration	Progressive Hepatolenticular Degeneration
Lenticular Degenerative Disease	Wilson'S Syndrome
Lenticular Syndrome

Combat Disorder

Combat Disorders

Combat Neurosis

Menkes Disease

Copper Transport Disease	Menkes Syndrome
MNK	Kinky Hair Disease
Steely Hair Disease	Menkes Kinky-Hair Syndrome
Mk	Steely Hair Syndrome
Menkea Syndrome	Md
Menkes Kinky Hair Syndrome	Hypocupremia, Congenital
Kinky Hair Syndrome	X-Linked Copper Deficiency
Menkes Kinky Hair Disease

Metal Metabolism Disorder

Metal Metabolism, Inborn Errors

Inborn Metal Metabolism Disorder

Deficiency Anemia

Anemia	Deficiency Anemias
Anaemia

Ovarian Cancer

Ovarian Carcinoma	Ovarian Neoplasm
Malignant Tumour Of Ovary	Cancer Of The Ovary
Epithelial Ovarian Cancer	Neoplasm Of Ovary
Ovarian Neoplasms	Ovarian Cancers
Malignant Neoplasm Of Ovary	Primary Malignant Neoplasm Of Ovary
Ovarian Cancer, Somatic	Malignant Ovarian Tumor
Ovary Neoplasm	Primary Ovarian Cancer
Tumor Of The Ovary	Malignant Neoplasm Of The Ovary
Malignant Tumor Of The Ovary	Ovarian Malignant Tumor
OC	Ovarian Carcinomas
Cancer, Ovarian	Cancer Of Ovary
Ovary Cancer	Ca Ovary

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS13188	SLC31A1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Macaca mulatta	SLC31A1	VGNC	VGNC:77455
Mus musculus	SLC31A1	MGD	MGI:1333843
Canis familiaris	SLC31A1	VGNC	VGNC:51761
Rattus norvegicus	SLC31A1	RGD	RGD:620059
Bos taurus	SLC31A1	VGNC	VGNC:34813
Felis catus	SLC31A1	VGNC	VGNC:102981
Others	SLC31A1	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

SLC31A1 - solute carrier family 31 member 1 Gene

关于 SLC31A1

功能概要

SLC31A1 基因产物(1)

SLC31A1 蛋白结构

SLC31A1 蛋白互作信息

重组 SLC31A1 蛋白

关联疾病

直系同源

热门区域

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SLC31A1 - solute carrier family 31 member 1 Gene

关于 SLC31A1

功能概要

SLC31A1 基因产物(1)

SLC31A1 蛋白结构

SLC31A1 蛋白互作信息

重组 SLC31A1 蛋白

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z