1. Gene
  2. Dll3 - delta like canonical Notch ligand 3 Gene

Dll3 - delta like canonical Notch ligand 3 Gene

种属: Mus musculus

同用名: pu; pudgy

基因 ID: 13389 | 基因类型: protein coding

关于 Dll3

功能概要

Predicted to enable Notch binding activity. Involved in skeletal system development. Acts upstream of or within anterior/posterior pattern specification; negative regulation of neurogenesis; and paraxial mesoderm development. Predicted to be located in membrane. Predicted to be integral component of membrane. Is expressed in several structures, including blastocyst; central nervous system; future brain; paraxial mesenchyme; and sensory organ. Used to study spondylocostal dysostosis. Human ortholog(s) of this gene implicated in dysostosis and spondylocostal dysostosis. Orthologous to human DLL3 (delta like canonical Notch ligand 3). [provided by Alliance of Genome Resources, Apr 2022]

Dll3 基因产物(1)

mRNA Protein Name
NM_007866.2 NP_031892.2 delta-like protein 3 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
16000382 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within compartment pattern specification IMP
IMP: 通过突变表型推断
12001066 MGI
acts upstream of or within negative regulation of neurogenesis IDA
IDA: 通过直接分析推断
9272948 MGI
acts upstream of or within paraxial mesoderm development IMP
IMP: 通过突变表型推断
15170697 MGI
involved in skeletal system development IMP
IMP: 通过突变表型推断
11923214 MGI
acts upstream of or within somitogenesis IDA
IDA: 通过直接分析推断
9272948 MGI
acts upstream of or within somitogenesis IMP
IMP: 通过突变表型推断
15170697 MGI
acts upstream of or within tissue development IDA
IDA: 通过直接分析推断
9272948 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in plasma membrane IDA
IDA: 通过直接分析推断
34635817 MGI
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断
蛋白主名 其他名称

delta-like protein 3

M-Delta-3

delta-like 3

delta3

drosophila Delta homolog 3

重组 Dll3 蛋白

目录号 产品名 蛋白编号 纯度
HY-P77916 Delta-like protein 3/DLL3 Protein, Mouse (HEK293, His) O88516-1 (A25-R488) ≥95%

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Dll3 NCBI NCBI:10683
Macaca fascicularis Dll3 NCBI NCBI:102115332
Macaca mulatta Dll3 NCBI NCBI:697453