PACRG - parkin coregulated Gene

中文名称：帕金共同调节

种属: Homo sapiens

同用名: GLUP; PACRG2.1; PARK2CRG; HAK005771

基因 ID: 135138 | 基因类型: protein coding

关于 PACRG

Cytogenetic location: 6q26 Genomic coordinates (GRCh38): 6:162,727,132-163,315,500 (from NCBI)

This gene has 10 transcripts (splice variants), 207 orthologues and 1 paralogue. Low expression observed in reference dataset.

功能概要

该基因编码一种跨后生动物保守的蛋白质。在脊椎动物中，该基因与相邻的帕金基因呈头对头排列，后者与常染色体隐性幼年帕金森病有关。这些基因在各种组织中共同调节，它们共享一个双向启动子。这两个基因都与麻风病的易感性有关。 parkin 共调节基因蛋白与伴侣蛋白形成大分子复合物，包括热休克蛋白 70 和 90，以及伴侣蛋白成分。这种蛋白质也是帕金森病患者路易体的组成部分，它抑制未折叠的 Pael 受体诱导的神经元细胞死亡。已发现该基因编码不同异构体的多个转录变体。[RefSeq 提供，2008 年 7 月]

This gene encodes a protein that is conserved across metazoans. In vertebrates, this gene is linked in a head-to-head arrangement with the adjacent parkin gene, which is associated with autosomal recessive juvenile Parkinson's disease. These genes are co-regulated in various tissues and they share a bi-directional promoter. Both genes are associated with susceptibility to leprosy. The parkin co-regulated gene protein forms a large molecular complex with chaperones, including heat shock proteins 70 and 90, and chaperonin components. This protein is also a component of Lewy bodies in Parkinson's disease patients, and it suppresses unfolded Pael receptor-induced neuronal cell death. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

PACRG 基因产物(3)

mRNA	Protein	Name
NM_001080378.2	NP_001073847.1	parkin coregulated gene protein isoform 2
NM_001080379.2	NP_001073848.1	parkin coregulated gene protein isoform 2
NM_152410.3	NP_689623.2	parkin coregulated gene protein isoform 1

基因本体论

分子功能
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables G protein-coupled receptor binding	IPI IPI: 通过物理相互作用推断	14532270	GOA
enables Hsp70 protein binding	IDA IDA: 通过直接分析推断	14532270	GOA
enables Hsp90 protein binding	IDA IDA: 通过直接分析推断	14532270	GOA
enables actin binding	IDA IDA: 通过直接分析推断	14532270	GOA
enables alpha-tubulin binding	IDA IDA: 通过直接分析推断	14532270	GOA
enables beta-tubulin binding	IDA IDA: 通过直接分析推断	14532270	GOA
enables heat shock protein binding	IPI IPI: 通过物理相互作用推断	14532270	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	32296183	GOA
enables protein-folding chaperone binding	IPI IPI: 通过物理相互作用推断	14532270	GOA
enables ubiquitin protein ligase binding	IPI IPI: 通过物理相互作用推断	14532270	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in axonemal microtubule	IDA IDA: 通过直接分析推断	36191189	GOA
located in cytosol	IDA IDA: 通过直接分析推断	14532270	GOA
located in neuron projection	IDA IDA: 通过直接分析推断	14532270	GOA
located in vesicle	IDA IDA: 通过直接分析推断	14532270	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PACRG 蛋白结构

ParcG

0
100
200
296 a.a.

蛋白主名

其他名称

parkin coregulated gene protein

PARK2 co-regulated

PACRG 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	PACRG	Q96M98	KLHL36	Homo sapiens	Q8N4N3	Anti Tag CoIP	33961781

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Parkinson Disease 2, Autosomal Recessive Juvenile

Young-Onset Parkinson Disease	PARK2
Pdj	Autosomal Recessive Juvenile Parkinson Disease 2
Epdf	Parkinson Disease, Juvenile, Type 2
Parkinson'S Disease 2	Autosomal Recessive Juvenile Parkinson Disease
Early-Onset Parkinson Disease	Parkinson Disease 2
Parkinson Disease, Juvenile, Autosomal Recessive	Parkinsonism, Early-Onset, With Diurnal Fluctuation
Autosomal Recessive Juvenile Parkinson'S Disease 2	Jp
Juvenile Parkinsonism	Parkinson Disease Autosomal Recessive, Early Onset
Parkinsonism, Early Onset, With Diurnal Fluctuation	Yopd
Autosomal Recessive Early-Onset Parkinson Disease Type 2	Chromosome 6-Linked Autosomal Recessive Parkinsonism
Early-Onset Parkinsonism With Diurnal Fluctuation	Parkinsonism Young Adult Onset
Parkinson Disease, Type 2	Parkinsonism, Juvenile

Parkin Type Of Early-Onset Parkinson Disease

Park-Parkin

Prkn Parkinson Disease

Parkinsonism

Parkinsonism-Plus	Idiopathic Parkinsonism
Primary Parkinsonism	Paralysis Agitans Syndrome
Parkinsonian Syndrome	Trembling Paralysis
Paralysis Agitans	Shaking Palsy
Shaking Paralysis

Leprosy 3

Leprosy	Leprosy, Susceptibility To, 3
Hansen'S Disease	Leprosy, Susceptibility To
Hansen Disease	Infection Due To Mycobacterium Leprae
LPRS3	Leprosy, Type 3
Anaesthesia Leprosy	Anaesthetic Leprosy
Maculoanaesthetic Leprosy	Macular Leprosy
Leprosy Unspecified

Dermatitis, Atopic, 3

ATOD3	Dermatitis, Atopic, Susceptibility To, 3
Atopic Dermatitis 3	Dermatitis, Atopic, With Asthma
Dermatitis, Atopic 3	Atopic Dermatitis With Asthma

Indeterminate Leprosy

Uncharacteristic Leprosy

Tuberculoid Leprosy

Smooth Leprosy	Type T Leprosy
Leprosy Tuberculoid	Leprosy, Tuberculoid

Hydrocephalus

Hydrocephalus, Nonsyndromic, Autosomal Recessive	Hydrocephalus, X-Linked
Hydrocephalus Adverse Event	Hydrocephaly Nos

Paratyphoid Fever

Paratyphoid B Fever	Paratyphoid C Fever
Paratyphoid Fever A	Paratyphoid Fever B
Paratyphoid Fever C	Paratyphoid
Paratyphoid A	Paratyphoid A Fever
Paratyphoid B	Paratyphoid C
Infection Due To Salmonella Paratyphi

Lepromatous Leprosy

Leprosy, Lepromatous	Type L Leprosy
Leprosy Lepromatous

Parkinson Disease, Late-Onset

Parkinson Disease	Parkinson'S Disease
PD	PARK
Parkinson Disease, Susceptibility To	Late Onset Parkinson'S Disease
Late Onset Parkinson Disease	Paralysis Agitans
Primary Parkinsonism	Idiopathic Parkinson Disease
Parkinson'S	Parkinson Disease, Late-Onset, Susceptibility To
Parkinson Disease, Age Of Onset, Modifier	Lewy Body Parkinson Disease
Idiopathic Parkinson'S Disease	Pd - [Parkinson Disease]
Parkinson Disease Nos	Parkinson, Nos
Primary Parkinson Disease

Epilepsy, Myoclonic Juvenile

Juvenile Myoclonic Epilepsy	Janz Syndrome
Jme	Myoclonic Epilepsy, Juvenile, Susceptibility To, 1
EJM	Myoclonic Epilepsy, Juvenile
Petit Mal, Impulsive	Myoclonic Epilepsy, Juvenile 1
Myoclonic Epilepsy, Juvenile, 1	Adolescent Myoclonic Epilepsy
Juvenile Myoclonus Epilepsy	Juvenile Myoclonic Epilepsy 1
EJM1	Petit Mal Impulsive
Susceptibility To Juvenile Myoclonic Epilepsy 1	Myoclonic Epilepsy Juvenile
Epilepsy, Myoclonic, Juvenile	Myoclonic Epilepsy Of Janz
Jme - [Juvenile Myoclonic Epilepsy]

Primary Ciliary Dyskinesia

Immotile Cilia Syndrome	Kartagener Syndrome
Dextrocardia Bronchiectasis And Sinusitis	Pcd
Ciliary Motility Disorders	Ciliary Motility Disorder
Immotile Ciliary Syndrome	Ciliary Dyskinesia Primary
Ics	Polynesian Bronchiectasis
Dextrocardia-Bronchiectasis-Sinusitis Syndrome	Immotile Cilia Syndrome, Kartagener Type
Primary Ciliary Dyskinesia And Situs Inversus	Primary Ciliary Dyskinesia, Kartagener Type
Siewert Syndrome	Dyskinesia, Ciliary, Primary

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS09954	PACRG Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Macaca mulatta	PACRG	VGNC	VGNC:75646
Bos taurus	PACRG	VGNC	VGNC:55070
Mus musculus	PACRG	MGD	MGI:1916560
Felis catus	PACRG	VGNC	VGNC:102479
Rattus norvegicus	PACRG	RGD	RGD:1561027

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。	站点地图隐私声明
沪ICP备15051369号-4 上海工商沪公网安备31011502019417 沪(浦)应急管危经许[2021]201709(QFYS) 营业执照（三证合一）
Copyright © 2013-2025 MedChemExpress. All Rights Reserved.

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

PACRG - parkin coregulated Gene

关于 PACRG

功能概要

PACRG 基因产物(3)

PACRG 蛋白结构

PACRG 蛋白互作信息

关联疾病

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

姓名
邮箱 *

Sorry, but the email address you supplied was invalid.

PACRG - parkin coregulated Gene

关于 PACRG

功能概要

PACRG 基因产物(3)

PACRG 蛋白结构

PACRG 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z