CLDN3 - claudin 3 Gene

中文名称：密蛋白 3

种属: Homo sapiens

同用名: RVP1; HRVP1; C7orf1; CPE-R2; CPETR2

基因 ID: 1365 | 基因类型: protein coding

关于 CLDN3

Cytogenetic location: 7q11.23 Genomic coordinates (GRCh38): 7:73,768,997-73,770,270 (from NCBI)

This gene has 1 transcript (splice variant), 151 orthologues and 22 paralogues.

功能概要

紧密连接代表上皮或内皮细胞片中细胞间粘附的一种模式，在细胞周围形成连续密封，并作为物理屏障防止溶质和水自由通过细胞旁空间。这些连接由面向外的细胞质小叶中的多组连续网络链组成，在面向内的胞质外小叶中具有互补的凹槽。由这种无内含子基因编码的蛋白质是密蛋白家族的一员，是一种完整的膜蛋白，是紧密连接链的一个组成部分。它也是产气荚膜梭菌肠毒素的低亲和力受体，并且与大鼠中发现的假定细胞凋亡相关蛋白具有序列相似性。[RefSeq 提供，2008 年 7 月]

Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this intronless gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. It is also a low-affinity receptor for Clostridium perfringens enterotoxin, and shares aa sequence similarity with a putative apoptosis-related protein found in rat. [provided by RefSeq, Jul 2008]

CLDN3 基因产物(1)

mRNA	Protein	Name
NM_001306.4	NP_001297.1	claudin-3

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables identical protein binding	IDA IDA: 通过直接分析推断	28028216	GOA
enables identical protein binding	IPI IPI: 通过物理相互作用推断	25849148	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	25849148	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in actin cytoskeleton organization	IMP IMP: 通过突变表型推断	27593915	GOA
involved in bicellular tight junction assembly	IMP IMP: 通过突变表型推断	25849148	GOA
involved in negative regulation of cell migration	IMP IMP: 通过突变表型推断	27593915	GOA
involved in negative regulation of cell population proliferation	IMP IMP: 通过突变表型推断	27593915	GOA
involved in negative regulation of gene expression	IMP IMP: 通过突变表型推断	27593915	GOA
involved in negative regulation of wound healing	IMP IMP: 通过突变表型推断	27593915	GOA
involved in positive regulation of bicellular tight junction assembly	IMP IMP: 通过突变表型推断	20655293	GOA
involved in positive regulation of cell junction assembly	IMP IMP: 通过突变表型推断	27593915	GOA
involved in positive regulation of cell migration	IMP IMP: 通过突变表型推断	16103090	GOA
involved in positive regulation of gene expression	IMP IMP: 通过突变表型推断	27593915	GOA
involved in positive regulation of metallopeptidase activity	IMP IMP: 通过突变表型推断	16103090	GOA
involved in positive regulation of protein phosphorylation	IMP IMP: 通过突变表型推断	27593915	GOA
involved in positive regulation of wound healing	IMP IMP: 通过突变表型推断	16103090	GOA
involved in regulation of cell morphogenesis	IMP IMP: 通过突变表型推断	16103090	GOA
involved in regulation of membrane permeability	IMP IMP: 通过突变表型推断	20655293	GOA
involved in regulation of transepithelial transport	IMP IMP: 通过突变表型推断	27593915	GOA
involved in response to hypoxia	IEP IEP: 通过表达模式推断	15174142	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in apical junction complex	IMP IMP: 通过突变表型推断	27593915	GOA
located in bicellular tight junction	IDA IDA: 通过直接分析推断	25849148	GOA
located in cell-cell junction	IDA IDA: 通过直接分析推断	18774778	GOA
part of protein-containing complex	IDA IDA: 通过直接分析推断	25849148	GOA
located in tight junction	IDA IDA: 通过直接分析推断	30734065	GOA
located in tight junction	IMP IMP: 通过突变表型推断	20655293	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CLDN3 蛋白结构

PMP22_Claudin

0
100
200
220 a.a.

蛋白主名

其他名称

claudin-3

CPE-R 2

重组 CLDN3 蛋白

目录号	产品名	蛋白编号	纯度
HY-P72146	Claudin-3/CLDN3 Protein, Human (His-B2M)	O15551 (R30-R80)	≥95%
HY-P700472	Claudin-3/CLDN3 Protein-VLP, Human (HEK293, His)	O15551 (M1-V220)	/

关联疾病

疾病名称

别名

Papillary Carcinoma

Carcinoma, Papillary

Carcinoma Papillary

Williams-Beuren Syndrome

Williams Syndrome	WBS
Wms	Deletion 7q11.23
Monosomy 7q11.23	Chromosome 7q11.23 Deletion Syndrome, 1.5- To 1.8-Mb
Fanconi Schlesinger Syndrome	Beuren Syndrome
Elfin Facies Syndrome	Elfin Facies With Hypercalcemia
Hypercalcemia-Supravalvar Aortic Stenosis	Ws

Endometrial Cancer

Endometrial Carcinoma	Endometrial Neoplasm
Malignant Neoplasm Of Endometrium	Endometrioid Carcinoma
Endometrial Neoplasms	Carcinoma, Endometrioid
Endometrial Cancer, Familial	Endometrial Carcinoma, Somatic
Endometrial Cancer, Susceptibility To	Endometrial Ca
Malignant Endometrial Neoplasm	Neoplasm Of Endometrium
Primary Malignant Neoplasm Of Endometrium	Tumor Of Endometrium
Carcinoma Of The Endometrium	Endometrioid Carcinoma Of Female Reproductive System
ENDMC	Carcinoma Endometrioid
Endometrial Cancers	Cancer, Endometrial
Uterine Corpus Cancer

Ovarian Cancer

Ovarian Carcinoma	Ovarian Neoplasm
Malignant Tumour Of Ovary	Cancer Of The Ovary
Epithelial Ovarian Cancer	Neoplasm Of Ovary
Ovarian Neoplasms	Ovarian Cancers
Malignant Neoplasm Of Ovary	Primary Malignant Neoplasm Of Ovary
Ovarian Cancer, Somatic	Malignant Ovarian Tumor
Ovary Neoplasm	Primary Ovarian Cancer
Tumor Of The Ovary	Malignant Neoplasm Of The Ovary
Malignant Tumor Of The Ovary	Ovarian Malignant Tumor
OC	Ovarian Carcinomas
Cancer, Ovarian	Cancer Of Ovary
Ovary Cancer	Ca Ovary

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Gastric Cancer

Stomach Cancer	Gastric Carcinoma
Stomach Carcinoma	Gastric Cancer, Somatic
Gastric Neoplasm	Carcinoma Of Stomach
Stomach Neoplasms	Malignant Neoplasm Of Stomach
Gastric Cancer Risk After H. Pylori Infection	Cancer Of The Stomach
Adult Stomach Cancer	Adult Stomach Carcinoma
GASC	Gastric Cancer Intestinal
Gastric Cancers	Gastric Carcinomas
Cancer, Gastric	Stomach Neoplasm
Malignant Neoplasm Of Body Of Stomach	Malignant Tumor Of Lesser Curve Of Stomach
Gastrocarcinoma Of Unspecified Site	Leather Bottle Stomach
Carcinoma Of Fundus Of Stomach	Cancer Of Fundus Of Stomach
Primary Malignant Neoplasm Of Body Of Stomach	Cancer Of Body Of Stomach
Primary Malignant Neoplasm Of Pyloric Antrum	Pyloric Antrum Cancer
Malignant Tumour Of Stomach

Deafness, Autosomal Recessive 29

DFNB29	Autosomal Recessive Nonsyndromic Deafness 29
Autosomal Recessive Deafness 29	Deafness, Autosomal Recessive, 29
Non-Syndromic Neurosensory Deafness Autosomal Recessive Type 29	Non-Syndromic Sensorineural Deafness Autosomal Recessive Type 29
Deafness, Autosomal Recessive, Type 29

Perinatal Necrotizing Enterocolitis

Necrotizing Enterocolitis	Enterocolitis Necrotizing
Enterocolitis, Necrotizing	Necrotizing Enterocolitis In Fetus Or Newborn
Perinatal Necrotising Enterocolitis	Pseudomembranous Enterocolitis In Newborn
Nec

Ovarian Cystadenoma

Cystoma Serosum Simplex	Simple Cystoma Of Ovary
Simple Cystoma Of The Ovary

Celiac Disease 1

Celiac Disease	Coeliac Disease
Celiac Sprue	Celiac Disease, Susceptibility To
Gluten-Sensitive Enteropathy	Nontropical Sprue
Sprue	CELIAC1
Celiac Disease, Susceptibility To, 1	Celiac Sprue 1
Celiac Sprue, Susceptibility To, 1	Gluten-Sensitive Enteropathy 1
Gluten-Sensitive Enteropathy, Susceptibility To, 1	Idiopathic Steatorrhea
Cœliac Disease	Gluten Intolerance
Gluten-Induced Enteropathy	Gluten Enteropathy
Celiac Disease, Susceptibility To, Type 1	Childhood Celiac Disease
Coeliac Rickets	Gee Disease
Gee-Herter Disease	Heubner-Herter Disease
Idiopathic Steatorrhoea	Thaysen'S Disease
Herter Gee Syndrome

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS02771	CLDN3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	CLDN3	MGD	MGI:1329044
Canis familiaris	CLDN3	VGNC	VGNC:39319
Bos taurus	CLDN3	VGNC	VGNC:27414
Rattus norvegicus	CLDN3	RGD	RGD:68425
Felis catus	CLDN3	VGNC	VGNC:107750
Macaca mulatta	CLDN3	VGNC	VGNC:71250
Others	CLDN3	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

CLDN3 - claudin 3 Gene

关于 CLDN3

功能概要

CLDN3 基因产物(1)

CLDN3 蛋白结构

重组 CLDN3 蛋白

关联疾病

直系同源

热门区域

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CLDN3 - claudin 3 Gene

关于 CLDN3

功能概要

CLDN3 基因产物(1)

CLDN3 蛋白结构

重组 CLDN3 蛋白

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z