2. Gene
  3. Epo - erythropoietin Gene

Epo - erythropoietin Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

基因 ID: 13856 | 基因类型: protein coding

关于 Epo

功能概要

This gene encodes the glycoprotein hormone erythropoietin that regulates the production of red blood cells and biosynthesis of hemoglobin. The predominant expression of this gene shifts from the liver during fetal development to kidney in adults. A complete lack of the encoded protein causes embryonic lethal anemia in mice. The conditional inactivation of this gene in adult mice results in a chronic, normocytic and normochromic anemia. Transgenic mice expressing the human ortholog of this gene exhibit polycythemia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2015]

Epo 基因产物(2)

mRNA Protein Name
NM_001312875.1 NP_001299804.1 erythropoietin isoform 2 precursor
NM_007942.2 NP_031968.1 erythropoietin isoform 1 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein kinase activator activity IDA
IDA: 通过直接分析推断
21095239 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within apoptotic process IDA
IDA: 通过直接分析推断
17300687 MGI
acts upstream of or within embryo implantation IDA
IDA: 通过直接分析推断
17300687 MGI
acts upstream of or within erythrocyte differentiation IDA
IDA: 通过直接分析推断
15591122 MGI
acts upstream of or within hemoglobin biosynthetic process IDA
IDA: 通过直接分析推断
17300687 MGI
acts upstream of myeloid cell apoptotic process IDA
IDA: 通过直接分析推断
17981124 MGI
involved in negative regulation of apoptotic process IDA
IDA: 通过直接分析推断
21095239 MGI
acts upstream of or within negative regulation of myeloid cell apoptotic process IDA
IDA: 通过直接分析推断
17981124 MGI
involved in peptidyl-serine phosphorylation IDA
IDA: 通过直接分析推断
21095239 MGI
involved in positive regulation of protein kinase activity IDA
IDA: 通过直接分析推断
21095239 MGI
acts upstream of or within regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
17300687 MGI
acts upstream of or within response to hypoxia IDA
IDA: 通过直接分析推断
15016652 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in extracellular space IDA
IDA: 通过直接分析推断
15016652 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

erythropoietin

重组 Epo 蛋白

目录号 产品名 蛋白编号 纯度
HY-P70409 Erythropoietin/EPO Protein, Mouse (HEK293, His) Q0VED9 (A27-R192) ≥95%
HY-P73038 Erythropoietin/EPO Protein, Mouse (HEK293, solution) NP_031968.1 (A27-R192) ≥95%

相关产品

Clinical Phase
生物活性分子 (2)
目录号 产品名 作用方式
纯度 Phase
HY-12654 Molidustat Inhibitor 98.75% Phase 3
HY-17029 Epothilone B 99.91% Phase 3
Pre-clinical Phase
生物活性分子 (15)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-145405 C12-200 99.91% 否
HY-13503 Epothilone A 99.75% 否
HY-W062700 STS-E412 Activator 99.72% 否
HY-N0403 2,3,4',5-Tetrahydroxystilbene 2-O-β-D-glucoside Inhibitor 99.78% 否
HY-136185 Atorvastatin Epoxy Tetrahydrofuran Impurity / 否
HY-141625 TRC160334 Inhibitor ≥95.0% 否
HY-141625A TRC160334 sodium Inhibitor / 否
HY-155009 PHD2-IN-1 Inhibitor / 否
HY-156526 PHD-IN-1 Inhibitor / 否
HY-161660 DS44470011 Inhibitor / 否
HY-162438 PHD2-IN-2 Inhibitor / 否
HY-163839 DS-1093a Inhibitor / 否
HY-16444 Sagopilone / 否
HY-RS04446 EPO Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-W747868 Molidustat sodium Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Epo NCBI NCBI:2056
Macaca fascicularis Epo NCBI NCBI:101925524
Susscrofa domestica Epo NCBI
Rattus norvegicus Epo NCBI NCBI:24335
Macaca mulatta Epo NCBI NCBI:719294
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