Erbb4 - erb-b2 receptor tyrosine kinase 4 Gene

中文名称：erb-b2 受体酪氨酸激酶4

种属: Mus musculus

同用名: Her4; c-erbB-4

关于 Erbb4

功能概要

该基因编码的蛋白可启动蛋白酪氨酸激酶活性。参与多个过程，包括乳腺发育；神经系统发育；氮化合物代谢过程的正向调控。在几个过程的上游或内部起作用，包括细胞对表皮生长因子刺激的反应；肽基酪氨酸自磷酸化；和细胞凋亡过程的调节。位于 GABA 能突触和谷氨酸能突触中。是突触后密度膜的组成部分。是突触前膜的组成部分。以多种结构表达，包括大脑；早孕;胚胎外胚层；心;和乳腺原基。该基因的人类直系同源物与 19 型肌萎缩侧索硬化有关；结直肠癌；食道鳞状细胞癌；肝细胞癌；和肺腺癌。与人 ERBB4（erb-b2 受体酪氨酸激酶 4）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables protein tyrosine kinase activity. Involved in several processes, including mammary gland development; nervous system development; and positive regulation of nitrogen compound metabolic process. Acts upstream of or within several processes, including cellular response to epidermal growth factor stimulus; peptidyl-tyrosine autophosphorylation; and regulation of apoptotic process. Located in GABA-ergic synapse and glutamatergic synapse. Is integral component of postsynaptic density membrane. Is integral component of presynaptic membrane. Is expressed in several structures, including brain; early conceptus; embryo ectoderm; heart; and mammary gland primordium. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis type 19; colorectal cancer; esophagus squamous cell carcinoma; hepatocellular carcinoma; and lung adenocarcinoma. Orthologous to human ERBB4 (erb-b2 receptor tyrosine kinase 4). [provided by Alliance of Genome Resources, Apr 2022]