2. Gene
  3. Ezh1 - enhancer of zeste 1 polycomb repressive complex 2 subunit Gene

Ezh1 - enhancer of zeste 1 polycomb repressive complex 2 subunit Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：zeste 1 多梳抑制复合物 2 亚基的增强子

种属: Mus musculus

同用名: ENX-2

基因 ID: 14055 | 基因类型: protein coding

关于 Ezh1

Chromosome 11: 101,081,941-101,117,289 reverse strand.GRCm39:CM001004.3

This gene has 9 transcripts (splice variants), 234 orthologues, 20 paralogues and is associated with 13 phenotypes. Ubiquitous expression in lung adult (RPKM 16.7), kidney adult (RPKM 16.3) and 28 other tissues.

功能概要

该基因编码 Polycomb 组 (PcG) 家族的成员。编码的蛋白质可与相关的 zeste 增强子 2 (EZH2) 蛋白质互换，作为多梳抑制复合物 2 (PRC2) 的核心成分，后者在赖氨酸 27 甲基化组蛋白 H3 并导致受影响靶基因的转录抑制。该复合体参与胚胎干细胞分化过程中的细胞命运决定。 [RefSeq 提供，2014 年 9 月]

This gene encodes a member of the Polycomb-group (PcG) family. The encoded protein is interchangeable with the related Enhancer of zeste 2 (EZH2) protein as a core component of the polycomb repressive complex 2 (PRC2), which methylates histone H3 at lysine 27 and results in the transcriptional repression of affected target genes. This complex is involved in carrying out cell-fate decisions during embryonic stem cell differentiation. [provided by RefSeq, Sep 2014]

Ezh1 基因产物(13)

mRNA Protein Name
NM_001403815.1 NP_001390744.1 histone-lysine N-methyltransferase EZH1 isoform 9
NM_001403812.1 NP_001390741.1 histone-lysine N-methyltransferase EZH1 isoform 6
NM_001403811.1 NP_001390740.1 histone-lysine N-methyltransferase EZH1 isoform 5
NM_001403809.1 NP_001390738.1 histone-lysine N-methyltransferase EZH1 isoform 3
NM_001403822.1 NP_001390751.1 histone-lysine N-methyltransferase EZH1 isoform 4
NM_001403807.1 NP_001390736.1 histone-lysine N-methyltransferase EZH1 isoform 2
NM_001403821.1 NP_001390750.1 histone-lysine N-methyltransferase EZH1 isoform 1
NM_001403814.1 NP_001390743.1 histone-lysine N-methyltransferase EZH1 isoform 8
NM_001403816.1 NP_001390745.1 histone-lysine N-methyltransferase EZH1 isoform 10
NM_001403810.1 NP_001390739.1 histone-lysine N-methyltransferase EZH1 isoform 4
NM_001403818.1 NP_001390747.1 histone-lysine N-methyltransferase EZH1 isoform 11
NM_001403813.1 NP_001390742.1 histone-lysine N-methyltransferase EZH1 isoform 7
NM_007970.4 NP_031996.1 histone-lysine N-methyltransferase EZH1 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
NOT enables DNA binding IDA
IDA: 通过直接分析推断
19026781 MGI
enables histone H3K27 methyltransferase activity IDA
IDA: 通过直接分析推断
19303854 MGI
contributes to histone binding IDA
IDA: 通过直接分析推断
19026781 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
9584197 MGI
enables transcription corepressor activity IDA
IDA: 通过直接分析推断
19026781 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in chromatin remodeling IDA
IDA: 通过直接分析推断
19026781 MGI
involved in facultative heterochromatin formation IDA
IDA: 通过直接分析推断
20064376 MGI
acts upstream of or within hepatocyte homeostasis IGI
IGI: 通过遗传相互作用推断
25477280 MGI
involved in heterochromatin formation IDA
IDA: 通过直接分析推断
19026781 MGI
acts upstream of or within liver regeneration IGI
IGI: 通过遗传相互作用推断
25477280 MGI
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
19026781 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
19303854 MGI
acts upstream of or within response to tetrachloromethane IGI
IGI: 通过遗传相互作用推断
25477280 MGI
involved in subtelomeric heterochromatin formation IGI
IGI: 通过遗传相互作用推断
9214638 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of ESC/E(Z) complex IDA
IDA: 通过直接分析推断
19026781 MGI
located in chromosome, telomeric region IGI
IGI: 通过遗传相互作用推断
9214638 MGI
located in heterochromatin IDA
IDA: 通过直接分析推断
19026781 MGI
located in nucleus IDA
IDA: 通过直接分析推断
9584197 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Ezh1 蛋白结构

EZH2_WD-Binding

EZH2_WD-Binding: pfam11616 (41 - 70)

PRC2_HTH_1

PRC2_HTH_1: pfam18118 (161 - 264)

SANT

SANT: cd00167 (435 - 476)

SET

SET: cl34524 (465 - 729)

SET_EZH1

SET_EZH1: cd19217 (610 - 745)

  • 0
  • 200
  • 400
  • 600
  • 750 a.a.
蛋白主名 其他名称

histone-lysine N-methyltransferase EZH1

enhancer of zeste homolog 1

Ezh1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
Ezh1 P70351 Mtf2 Mus musculus Q02395
Anti Tag CoIP
20064376
种属内
Ezh1 P70351 Jarid2 Mus musculus Q62315
Anti Tag CoIP
20064376
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Approval
生物活性分子 (2)
目录号 产品名 作用方式
纯度 是否罕见病
HY-109108 Valemetostat Inhibitor 99.84% 否
HY-109108A Valemetostat tosylate Inhibitor 98.14% 否
Clinical Phase
生物活性分子 (1)
目录号 产品名 作用方式
纯度 Phase
HY-145602 Tulmimetostat Inhibitor 99.79% Phase 2
Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-15646 UNC1999 Inhibitor 99.83% 否
HY-144881 (S)-HH2853 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Ezh1 NCBI NCBI:2145
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