SELENOM - selenoprotein M Gene

中文名称：硒蛋白 M

种属: Homo sapiens

同用名: SELM; SEPM

关于 SELENOM

功能概要

该基因编码的蛋白质属于硒蛋白 M/SEP15 家族。这种蛋白质的确切功能尚不清楚。它定位于核周区域，在大脑中高度表达，并可能与神经退行性疾病有关。靶向删除该基因的转基因小鼠体重增加增加，表明该基因在调节体重和能量代谢中发挥作用。这种蛋白质是一种硒蛋白，含有稀有氨基酸硒代半胱氨酸 (Sec) 。 Sec 由 UGA 密码子编码，通常表示翻译终止。硒蛋白 mRNA 的 3' UTR 包含一个保守的茎环结构，称为 Sec 插入序列 (SECIS) 元件，这是将 UGA 识别为 Sec 密码子而不是终止信号所必需的。[RefSeq 提供，2016 年 12 月]

The protein encoded by this gene belongs to the selenoprotein M/SEP15 family. The exact function of this protein is not known. It is localized in the perinuclear region, is highly expressed in the brain, and may be involved in neurodegenerative disorders. Transgenic mice with targeted deletion of this gene exhibit increased weight gain, suggesting a role for this gene in the regulation of body weight and energy metabolism. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. [provided by RefSeq, Dec 2016]