2. Gene
  3. BPIFA2 - BPI fold containing family A member 2 Gene

BPIFA2 - BPI fold containing family A member 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：含 BPI 折叠家族 A 成员 2

种属: Homo sapiens

同用名: PSP; SPLUNC2; C20orf70; bA49G10.1

基因 ID: 140683 | 基因类型: protein coding

关于 BPIFA2

This gene has 2 transcripts (splice variants), 89 orthologues and 12 paralogues. Restricted expression toward salivary gland (RPKM 1129.7).

功能概要

该基因编码上颚、肺和鼻上皮细胞克隆 (Plunc) 蛋白质家族的成员。该家族的成员已被提议在鼻子、嘴巴和上呼吸道的局部抗菌反应中发挥作用。编码的可溶性唾液蛋白结合细菌脂多糖 (LPS) 并抑制细菌生长。该基因存在于 20 号染色体上的基因簇中。可变剪接导致多个转录本变体。[RefSeq 提供，2016 年 1 月]

This gene encodes a member of the palate, lung and nasal epithelium clone (Plunc) family of proteins. Members of this family have been proposed to play a role in the local Antibacterial response in nose, mouth and upper respiratory pathways. The encoded soluble salivary protein binds Bacterial lipopolysaccharide (LPS) and inhibits Bacterial growth. This gene is present in a gene cluster on chromosome 20. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

BPIFA2 基因产物(2)

mRNA Protein Name
NM_001319164.2 NP_001306093.1 BPI fold-containing family A member 2 precursor
NM_080574.4 NP_542141.1 BPI fold-containing family A member 2 precursor
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables lipopolysaccharide binding IDA
IDA: 通过直接分析推断
21833535 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
25416956 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in extracellular region IDA
IDA: 通过直接分析推断
19499239 GOA
located in extracellular space IDA
IDA: 通过直接分析推断
28775000 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

BPIFA2 蛋白结构

LBP_BPI_CETP

LBP_BPI_CETP: LBP / BPI / CETP family, N-terminal domain (62 - 227)

  • 0
  • 100
  • 200
  • 249 a.a.
蛋白主名 其他名称

BPI fold-containing family A member 2

parotid secretory protein

重组 BPIFA2 蛋白

目录号 产品名 蛋白编号 纯度
HY-P76749 BPIFA2 Protein, Human (HEK293, Fc) Q96DR5 (E19-I249) ≥95%
HY-P76750 BPIFA2 Protein, Human (HEK293, His) Q96DR5 (E19-I249) ≥95%

关联疾病

疾病名称 别名
Papillary Cystadenocarcinoma

Cystadenocarcinoma, Papillary
Xerophthalmia

Conjunctival Xerosis
Parotid Disease

Parotid Diseases
Lacrimal Apparatus Disease

Lacrimal Apparatus Diseases
Filamentary Keratitis
Sialadenitis

Sialoadenitis

Adenitis, Salivary Gland

Salivary Gland Inflammation

Salivary Gland Adenitis

Sialitis

Inflammation Of Salivary Gland

Inflammation Of Salivary Duct Or Gland

Salivary Glandular Adenitis

Sialoangiitis

Sialoangitis

Sialodochitis
Parotitis
Dry Eye Syndrome

Dry Eye Syndromes

Dry Eye Disease

Tear Film Insufficiency

Xerophthalmia
Lagophthalmos

Defective Lid Closure

Poor Closure Eyelids
Keratoconjunctivitis Sicca

Kcs

Dry Eye Syndromes

Keratitis Sicca

Xerophthalmia
Dacryoadenitis

Dacryocystitis
Autoimmune Disease Of Exocrine System
Potocki-Shaffer Syndrome

Proximal 11p Deletion Syndrome

Chromosome 11p11.2 Deletion Syndrome

Pss

11p11.2 Deletion

P11pds

Defect11 Syndrome

Deletion Of Chromosome 11p11.2

POSHS
Salivary Gland Disease

Salivary Gland Disorders

Salivary Gland Diseases

Non-Neoplastic Salivary Gland Disease

Non-Neoplastic Salivary Gland Disorder

Disorder Of Salivary Gland

Lesion Of Salivary Gland Nos
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS01582 BPIFA2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta BPIFA2 VGNC VGNC:107773
Rattus norvegicus BPIFA2 RGD RGD:3431
Mus musculus BPIFA2 MGD MGI:97787
Canis familiaris BPIFA2 VGNC VGNC:38505
Others BPIFA2 NCBI
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