CRY1 - cryptochrome circadian regulator 1 Gene

中文名称：隐花色素昼夜节律调节器 1

种属: Homo sapiens

同用名: DSPD; PHLL1

基因 ID: 1407 | 基因类型: protein coding

关于 CRY1

Cytogenetic location: 12q23.3 Genomic coordinates (GRCh38): 12:106,991,364-107,093,549 (from NCBI)

This gene has 5 transcripts (splice variants), 262 orthologues, 1 paralogue and is associated with 1 phenotype. Broad expression in testis (RPKM 23.5), thyroid (RPKM 10.6) and 25 other tissues.

功能概要

该基因编码一种黄素腺嘌呤二核苷酸结合蛋白，它是调节生物钟的昼夜节律核心振荡器复合体的关键组成部分。该基因被 CLOCK/ARNTL 异二聚体上调，但随后使用 PER/CRY 异二聚体与 CLOCK/ARNTL 相互作用在反馈回路中抑制这种上调。该基因的多态性与睡眠模式的改变有关。编码的蛋白质在植物和动物中广泛保存。小鼠相关基因的缺失导致完全黑暗中的昼夜节律周期缩短。[RefSeq 提供，2014 年 1 月]

This gene encodes a flavin adenine dinucleotide-binding protein that is a key component of the circadian core oscillator complex, which regulates the circadian clock. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene have been associated with altered sleep patterns. The encoded protein is widely conserved across Plants and Animals. Loss of the related gene in mouse results in a shortened circadian cycle in complete darkness. [provided by RefSeq, Jan 2014]

CRY1 基因产物(14)

mRNA	Protein	Name
NM_001413458.1	NP_001400387.1	cryptochrome-1 isoform a
NM_001413459.1	NP_001400388.1	cryptochrome-1 isoform b
NM_001413460.1	NP_001400389.1	cryptochrome-1 isoform c
NM_001413461.1	NP_001400390.1	cryptochrome-1 isoform d
NM_001413462.1	NP_001400391.1	cryptochrome-1 isoform d
NM_001413463.1	NP_001400392.1	cryptochrome-1 isoform e
NM_001413464.1	NP_001400393.1	cryptochrome-1 isoform f
NM_001413465.1	NP_001400394.1	cryptochrome-1 isoform f
NM_001413466.1	NP_001400395.1	cryptochrome-1 isoform g
NM_001413467.1	NP_001400396.1	cryptochrome-1 isoform h
NM_001413468.1	NP_001400397.1	cryptochrome-1 isoform h
NM_001413469.1	NP_001400398.1	cryptochrome-1 isoform h
NM_001413470.1	NP_001400399.1	cryptochrome-1 isoform h
NM_004075.5	NP_004066.1	cryptochrome-1 isoform d

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
NOT enables DNA (6-4) photolyase activity	IDA IDA: 通过直接分析推断	8909283	GOA
NOT enables deoxyribodipyrimidine photo-lyase activity	IDA IDA: 通过直接分析推断	8909283	GOA
enables double-stranded DNA binding	IDA IDA: 通过直接分析推断	9801304	GOA
enables nuclear receptor binding	IPI IPI: 通过物理相互作用推断	22170608	GOA
enables phosphatase binding	IPI IPI: 通过物理相互作用推断	9383998	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	9383998	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in negative regulation of DNA-templated transcription	IDA IDA: 通过直接分析推断	12397359	GOA
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	12397359	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in nucleus	IDA IDA: 通过直接分析推断	26431207	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CRY1 蛋白结构

DNA_photolyase

FAD_binding_7

0
100
200
300
400
500
586 a.a.

蛋白主名

其他名称

cryptochrome-1

cryptochrome 1 (photolyase-like)

关联疾病

疾病名称

别名

Delayed Sleep Phase Disorder

Delayed Sleep Phase Syndrome	Delayed Sleep Phase Syndrome, Susceptibility To
DSPD	Delayed Sleep Phase Disorder, Susceptibility To
DSPS	Sleep Phase, Delayed, Disorder
Sleep Phase Syndrome, Delayed, Susceptibility To

Sleep Disorder

Sleep Disorders

Non-Organic Sleep Disorder

Advanced Sleep Phase Syndrome

Fasps	Familial Advanced Sleep-Phase Syndrome
Advanced Sleep Phase Syndrome, Familial	Familial Advanced Sleep Phase Syndrome
Sleep Phase Syndrome, Advanced, Familial	Advanced Sleep-Phase Syndrome, Familial

Sleep Apnea

Sleep Apnea Syndromes

Attention Deficit-Hyperactivity Disorder

Attention Deficit Hyperactivity Disorder	ADHD
Attention Deficit Disorder	Attention Deficit-Hyperactivity Disorder, Susceptibility To
Attention Deficit Disorder With Hyperactivity	Hyperkinetic Disorder
Hyperactivity Of Childhood	Attention-Deficit/Hyperactivity Disorder
Add	Addh
Attention Deficit	Attention Deficit Disorder Of Childhood With Hyperactivity
Attention Deficit Disorder With Hyperactivity Syndrome	Hyperkinetic Syndrome
Attention-Deficit Hyperactivity Disorder	Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type
Disturbance Of Activity And Attention	Disorder Of Activity And Attention
Adhd - [Attention Deficit Hyperactivity Disorder]	Hyperkinetic Disorders
Disorder Of Activity And Attention With Hyperkinesia	Attention Deficit Syndrome With Hyperactivity

Major Depressive Disorder

Seasonal Affective Disorder	Unipolar Depression
Depression	MDD
Depressive Disorder	Unipolar Depression, Susceptibility To
Major Depressive Disorder 1	Major Depressive Disorder, Response To Citalopram Therapy In
Major Depressive Disorder 2	Winter Depression
Single Major Depressive Episode	Sad
Clinical Depression	Major Depression
Depressive Syndrome	Major Depressive Disorder And Accelerated Response To Antidepressant Drug Treatment
Seasonal Affective Disorder, Susceptibility To	Recurrent Major Depression
Affective Disorder, Seasonal	Depression In A Seasonal Pattern
Depression	Seasonal
Major Depressive Disorder With A Seasonal Pattern	Seasonal Depression
Seasonal Mood Disorder	Mental Depression
Recurrent Major Depressive Episodes

Bipolar Disorder

Bipolar Depression	Manic Disorder
Depression, Bipolar	Bipolar Disorder Manic Phase
Depressive-Manic Psych.	Manic Bipolar Affective Disorder
Manic Bipolar I Disorder	Manic Depression
Manic Depressive Disorder	Mixed Bipolar Disorder
Bipolar Affective Disorder	Bipolar Affective Psychosis
Bipolar Spectrum Disorder	Manic Depressive Illness
Depression Bipolar	Bipolar Disorder, Mixed
Major Affective Disorder	Major Affective Disorder 1
Major Affective Disorder 2

Apnea, Obstructive Sleep

Obstructive Sleep Apnea Syndrome	Obstructive Sleep Apnea
Sleep Apnea, Obstructive	Osa
Osas	Sleep Apnea/Hypopnea Syndrome
Sahs	Upper Airway Resistance Sleep Apnea Syndrome
Apnea, Obstructive	Obstructive Apnea
Osahs	Sleep Apnea Hypopnea Syndrome
Sleep Apnea Syndrome, Obstructive	Sleep Apnea Obstructive
Sleep Apnea Syndromes	Obstructive Sleep Apnoea Syndrome
Obstructive Sleep Apnoea, Adult	Osa - [Obstructive Sleep Apnoea]
Obstructive Sleep Apnoea, Paediatric	Obstructive Sleep Apnoea Hypopnoea Syndrome
Osa Syndrome	Sleep Apnoea Nos
[Sas] - Sleep Apnoea Syndrome	Sleep Apnoea Syndrome
[Osahs] - Obstructive Sleep Apnoea-Hypopnea Syndrome	[Sahs] - Sleep Apnoea-Hypopnea Syndrome

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-108468	KL001		99.68%	否
HY-115672	KS15		99.40%	否
HY-134194	KL201		98.15%	否
HY-148764	M47	Inducer	99.90%	否
HY-RS03204	CRY1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Macaca mulatta	CRY1	VGNC	VGNC:71499
Bos taurus	CRY1	VGNC	VGNC:27730
Felis catus	CRY1	VGNC	VGNC:61195
Canis familiaris	CRY1	VGNC	VGNC:39633
Mus musculus	CRY1	MGD	MGI:1270841
Rattus norvegicus	CRY1	RGD	RGD:735083

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

CRY1 - cryptochrome circadian regulator 1 Gene

关于 CRY1

功能概要

CRY1 基因产物(14)

CRY1 蛋白结构

关联疾病

直系同源

热门区域

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CRY1 - cryptochrome circadian regulator 1 Gene

关于 CRY1

功能概要

CRY1 基因产物(14)

CRY1 蛋白结构

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z