2. Gene
  3. Ptk2 - PTK2 protein tyrosine kinase 2 Gene

Ptk2 - PTK2 protein tyrosine kinase 2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：PTK2 蛋白酪氨酸激酶 2

种属: Mus musculus

同用名: FAK; FRNK; Fadk; FADK 1; p125FAK

基因 ID: 14083 | 基因类型: protein coding

关于 Ptk2

Chromosome 15: 73,076,951-73,295,129 reverse strand.GRCm39:CM001008.3

This gene has 16 transcripts (splice variants), 230 orthologues, 32 paralogues and is associated with 64 phenotypes. Ubiquitous expression in cortex adult (RPKM 12.3), CNS E11.5 (RPKM 11.8) and 28 other tissues.

功能概要

该基因编码的蛋白可启动非跨膜蛋白酪氨酸激酶活性。参与细胞群增殖的正调控；泛素依赖性蛋白质分解代谢过程的正调控；和蛋白质磷酸化。作用于多个过程的上游或内部，包括血管形态发生；神经元的产生；和肽基酪氨酸自磷酸化。位于几种细胞成分中，包括顶端质膜；粘着斑；和片状足。以多种结构表达，包括消化系统；中枢神经系统;眼睛;泌尿生殖系统；和卵黄囊。该基因的人类直系同源物与平滑肌瘤有关；肺小细胞癌；和肺动脉高压。与人 PTK2（蛋白酪氨酸激酶 2）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables non-membrane spanning protein tyrosine kinase activity. Involved in positive regulation of cell population proliferation; positive regulation of ubiquitin-dependent protein catabolic process; and protein phosphorylation. Acts upstream of or within several processes, including blood vessel morphogenesis; generation of neurons; and peptidyl-tyrosine autophosphorylation. Located in several cellular components, including apical plasma membrane; focal adhesion; and lamellipodium. Is expressed in several structures, including alimentary system; central nervous system; eye; genitourinary system; and yolk sac. Human ortholog(s) of this gene implicated in leiomyoma; lung small cell carcinoma; and pulmonary hypertension. Orthologous to human PTK2 (protein tyrosine kinase 2). [provided by Alliance of Genome Resources, Apr 2022]

Ptk2 基因产物(3)

mRNA Protein Name
NM_001358045.1 NP_001344974.1 focal adhesion kinase 1 isoform 3
NM_001358046.1 NP_001344975.1 focal adhesion kinase 1 isoform 4
NM_007982.2 NP_032008.2 focal adhesion kinase 1 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables non-membrane spanning protein tyrosine kinase activity IMP
IMP: 通过突变表型推断
18297732 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
7479864 MGI
enables protein tyrosine kinase activity EXP
EXP: 通过实验结果推断
16298995 MGI
enables protein tyrosine kinase activity IDA
IDA: 通过直接分析推断
7529876 MGI
enables protein tyrosine kinase activity IMP
IMP: 通过突变表型推断
25059660 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within angiogenesis IMP
IMP: 通过突变表型推断
15967814 MGI
acts upstream of axonogenesis IMP
IMP: 通过突变表型推断
15378065 MGI
acts upstream of or within blood vessel development IMP
IMP: 通过突变表型推断
12595342 MGI
acts upstream of or within cellular response to transforming growth factor beta stimulus IDA
IDA: 通过直接分析推断
21829547 MGI
acts upstream of or within central nervous system neuron axonogenesis IMP
IMP: 通过突变表型推断
15378065 MGI
acts upstream of or within endothelial cell migration IMP
IMP: 通过突变表型推断
15967814 MGI
acts upstream of or within extracellular matrix organization IMP
IMP: 通过突变表型推断
14642275 MGI
acts upstream of or within microtubule cytoskeleton organization IDA
IDA: 通过直接分析推断
12941275 MGI
acts upstream of or within negative regulation of autophagy IDA
IDA: 通过直接分析推断
27994061 MGI
acts upstream of or within negative regulation of autophagy IMP
IMP: 通过突变表型推断
27994061 MGI
acts upstream of or within negative regulation of axonogenesis IMP
IMP: 通过突变表型推断
15378065 MGI
acts upstream of or within negative regulation of organ growth IGI
IGI: 通过遗传相互作用推断
16374517 MGI
acts upstream of or within negative regulation of synapse assembly IMP
IMP: 通过突变表型推断
15378065 MGI
acts upstream of or within neuron migration IDA
IDA: 通过直接分析推断
12941275 MGI
acts upstream of or within neuron migration IMP
IMP: 通过突变表型推断
14642275 MGI
acts upstream of or within nuclear migration IDA
IDA: 通过直接分析推断
12941275 MGI
acts upstream of organ growth IGI
IGI: 通过遗传相互作用推断
16374517 MGI
acts upstream of or within peptidyl-tyrosine autophosphorylation IDA
IDA: 通过直接分析推断
27994061 MGI
acts upstream of or within peptidyl-tyrosine phosphorylation IDA
IDA: 通过直接分析推断
27994061 MGI
involved in peptidyl-tyrosine phosphorylation IDA
IDA: 通过直接分析推断
7529876 MGI
involved in peptidyl-tyrosine phosphorylation IMP
IMP: 通过突变表型推断
18297732 MGI
acts upstream of or within positive regulation of cardiac muscle hypertrophy IDA
IDA: 通过直接分析推断
27994061 MGI
involved in positive regulation of cell population proliferation IMP
IMP: 通过突变表型推断
18206965 MGI
involved in positive regulation of ubiquitin-dependent protein catabolic process IMP
IMP: 通过突变表型推断
18206965 MGI
involved in protein autophosphorylation IDA
IDA: 通过直接分析推断
7529876 MGI
acts upstream of or within protein autophosphorylation IMP
IMP: 通过突变表型推断
2132399 MGI
involved in regulation of modification of postsynaptic actin cytoskeleton IDA
IDA: 通过直接分析推断
19553453 MGI
involved in regulation of modification of postsynaptic actin cytoskeleton IMP
IMP: 通过突变表型推断
19553453 MGI
acts upstream of or within vasculogenesis IMP
IMP: 通过突变表型推断
15967814 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in apical plasma membrane IDA
IDA: 通过直接分析推断
10742111 MGI
located in focal adhesion IDA
IDA: 通过直接分析推断
10699171 MGI
is active in glutamatergic synapse IDA
IDA: 通过直接分析推断
19553453 MGI
is active in glutamatergic synapse IMP
IMP: 通过突变表型推断
19553453 MGI
located in lamellipodium IDA
IDA: 通过直接分析推断
15728191 MGI
located in nucleus IDA
IDA: 通过直接分析推断
18206965 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Ptk2 蛋白结构

FERM_N_2

FERM_N_2: pfam18038 (34 - 129)

B41

B41: smart00295 (35 - 257)

FERM_C_FAK1

FERM_C_FAK1: cd13190 (253 - 363)

PTKc_FAK

PTKc_FAK: cd05056 (414 - 683)

Focal_AT

Focal_AT: pfam03623 (915 - 1044)

  • 0
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  • 400
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  • 800
  • 1000
  • 1052 a.a.
蛋白主名 其他名称

focal adhesion kinase 1

focal adhesion kinase-related nonkinase

focal ashension kinase 1

pp125FAK

protein-tyrosine kinase 2

相关产品

Pre-clinical Phase
生物活性分子 (15)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-123919 TL13-112 Inhibitor 98.15% 否
HY-111546 BI-3663 Inhibitor 99.84% 否
HY-148063 DB0614 98.80% 否
HY-124625 BI-4464 Inhibitor 98.64% 否
HY-148061 DB1113 99.28% 否
HY-122582 TL13-12 Inhibitor 98.06% 否
HY-130422 Tos-PEG4-t-butyl ester / 否
HY-130521 Pomalidomide-amido-PEG3-C2-NH2 99.55% 否
HY-148065 FMF-06-098-1 98.02% 否
HY-RS11400 Ptk2 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-136194 TL13-22 Inhibitor 99.71% 否
HY-136195 TL13-110 Inhibitor / 否
HY-RS11399 PTK2 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS11401 Ptk2 Rat Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS11402 PTK2B Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Ptk2 NCBI NCBI:5747
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