2. Gene
  3. Fcgr2b - Fc receptor, IgG, low affinity IIb Gene

Fcgr2b - Fc receptor, IgG, low affinity IIb Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: CD32; Fcgr2; Fcr-2; Fcr-3; Ly-17; LyM-1; Lym-1; fcRII; FcgRII; Fcgr2a; Ly-m20; Fc[g]RII; F630109E10Rik

基因 ID: 14130 | 基因类型: protein coding

关于 Fcgr2b

功能概要

Enables IgG binding activity. Involved in several processes, including cellular response to amyloid-beta; nervous system development; and regulation of cellular response to stress. Acts upstream of or within several processes, including antigen processing and presentation of exogenous peptide antigen via MHC class II; negative regulation of immune effector process; and regulation of phagocytosis. Located in cell body; dendritic spine; and external side of plasma membrane. Is integral component of membrane. Is expressed in liver and spleen. Used to study malaria and systemic lupus erythematosus. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); dengue disease (multiple); hematologic Cancer (multiple); leukopenia (multiple); and malaria (multiple). Orthologous to several human genes including FCGR2B (Fc fragment of IgG receptor IIb). [provided by Alliance of Genome Resources, Apr 2022]

Fcgr2b 基因产物(2)

mRNA Protein Name
NM_001077189.1 NP_001070657.1 low affinity immunoglobulin gamma Fc region receptor II-b isoform 1
NM_010187.2 NP_034317.1 low affinity immunoglobulin gamma Fc region receptor II-b isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables IgG binding IDA
IDA: 通过直接分析推断
9551950 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
12893283 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of B cell proliferation IMP
IMP: 通过突变表型推断
12385742 MGI
involved in Fc receptor-mediated immune complex endocytosis IDA
IDA: 通过直接分析推断
28389502 MGI
acts upstream of or within antigen processing and presentation of exogenous peptide antigen via MHC class II IMP
IMP: 通过突变表型推断
14643301 MGI
acts upstream of or within cell surface receptor signaling pathway IMP
IMP: 通过突变表型推断
8552190 MGI
involved in cellular response to amyloid-beta IMP
IMP: 通过突变表型推断
23921129 MGI
acts upstream of or within cellular response to molecule of bacterial origin IMP
IMP: 通过突变表型推断
12385742 MGI
involved in cerebellum development IMP
IMP: 通过突变表型推断
17502348 MGI
acts upstream of or within defense response IMP
IMP: 通过突变表型推断
11994421 MGI
involved in dendrite development IMP
IMP: 通过突变表型推断
17502348 MGI
acts upstream of establishment of localization in cell IMP
IMP: 通过突变表型推断
12385742 MGI
acts upstream of or within immunoglobulin mediated immune response IMP
IMP: 通过突变表型推断
10395649 MGI
acts upstream of immunoglobulin production IMP
IMP: 通过突变表型推断
12385742 MGI
acts upstream of interleukin-10 production IMP
IMP: 通过突变表型推断
12385742 MGI
NOT acts upstream of or within mast cell activation IDA
IDA: 通过直接分析推断
8769481 MGI
acts upstream of or within negative regulation of B cell proliferation IMP
IMP: 通过突变表型推断
8552190 MGI
acts upstream of or within negative regulation of acute inflammatory response to antigenic stimulus IMP
IMP: 通过突变表型推断
12385742 MGI
acts upstream of or within negative regulation of humoral immune response mediated by circulating immunoglobulin IMP
IMP: 通过突变表型推断
12385742 MGI
acts upstream of or within negative regulation of immune response IMP
IMP: 通过突变表型推断
8552190 MGI
acts upstream of or within negative regulation of immunoglobulin production IMP
IMP: 通过突变表型推断
12385742 MGI
acts upstream of or within negative regulation of inflammatory response to antigenic stimulus IMP
IMP: 通过突变表型推断
16492738 MGI
acts upstream of or within negative regulation of interleukin-10 production IMP
IMP: 通过突变表型推断
12385742 MGI
acts upstream of or within negative regulation of phagocytosis IMP
IMP: 通过突变表型推断
12385742 MGI
acts upstream of or within negative regulation of type I hypersensitivity IMP
IMP: 通过突变表型推断
8552190 MGI
acts upstream of phagocytosis IMP
IMP: 通过突变表型推断
12385742 MGI
acts upstream of or within phagocytosis, engulfment IDA
IDA: 通过直接分析推断
8769481 MGI
involved in positive regulation of DNA-binding transcription factor activity IMP
IMP: 通过突变表型推断
23921129 MGI
involved in positive regulation of JNK cascade IMP
IMP: 通过突变表型推断
23921129 MGI
acts upstream of or within positive regulation of phagocytosis IDA
IDA: 通过直接分析推断
8769481 MGI
involved in positive regulation of response to endoplasmic reticulum stress IMP
IMP: 通过突变表型推断
23921129 MGI
involved in regulation of dendritic spine maintenance IMP
IMP: 通过突变表型推断
23921129 MGI
involved in regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway IMP
IMP: 通过突变表型推断
23921129 MGI
involved in regulation of long-term neuronal synaptic plasticity IMP
IMP: 通过突变表型推断
23921129 MGI
acts upstream of or within response to bacterium IMP
IMP: 通过突变表型推断
12385742 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cell body IDA
IDA: 通过直接分析推断
17502348 MGI
located in dendritic spine IDA
IDA: 通过直接分析推断
17502348 MGI
located in external side of plasma membrane IDA
IDA: 通过直接分析推断
8552190 MGI
located in membrane IDA
IDA: 通过直接分析推断
8552190 MGI
located in plasma membrane IDA
IDA: 通过直接分析推断
17502348 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

low affinity immunoglobulin gamma Fc region receptor II-b

Fc gamma RIIB

Fc-gamma-RII

FcgammaRIIB

fc gamma receptor IIB

fc-gamma RII

fc-gamma-RIIB

igG Fc receptor II beta

low affinity immunoglobulin gamma Fc region receptor II

lymphocyte antigen 17

重组 Fcgr2b 蛋白

目录号 产品名 蛋白编号 纯度
HY-P72735 Fc gamma RIIB/CD32b Protein, Mouse (HEK293, His) P08101 (T30-P210) ≥95%
HY-P75649 Fc gamma RIIB/CD32b Protein, Mouse (Biotinylated, HEK293, His-Avi) A0A0B4J1E6/NP_001070657 (M1-R217) ≥95%

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS04829 FCGR2B Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Fcgr2b NCBI NCBI:2213
Macaca fascicularis Fcgr2b NCBI NCBI:102139530
Rattus norvegicus Fcgr2b NCBI NCBI:289211
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