2. Gene
  3. MIB2 - MIB E3 ubiquitin protein ligase 2 Gene

MIB2 - MIB E3 ubiquitin protein ligase 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：MIB E3 泛素蛋白连接酶 2

种属: Homo sapiens

同用名: ZZZ5; ZZANK1

基因 ID: 142678 | 基因类型: protein coding

关于 MIB2

Cytogenetic location: 1p36.33 Genomic coordinates (GRCh38): 1:1,613,731-1,630,605 (from NCBI)

This gene has 32 transcripts (splice variants), 200 orthologues, 1 paralogue and is associated with 1 phenotype. Ubiquitous expression in spleen (RPKM 6.7), fat (RPKM 5.7) and 25 other tissues.

功能概要

该基因编码的蛋白质是一种 E3 泛素蛋白连接酶，可介导 Notch 信号通路中蛋白质的泛素化。编码的蛋白质可能是黑色素瘤侵袭的抑制因子。[RefSeq 提供，2017 年 3 月]

The protein encoded by this gene is an E3 ubiquitin protein Ligase that mediates ubiquitination of proteins in the Notch signaling pathway. The encoded protein may be a suppressor of melanoma invasion. [provided by RefSeq, Mar 2017]

MIB2 基因产物(5)

mRNA Protein Name
NM_001170686.4 NP_001164157.3 E3 ubiquitin-protein ligase MIB2 isoform 2
NM_001170687.4 NP_001164158.3 E3 ubiquitin-protein ligase MIB2 isoform 1
NM_001170688.2 NP_001164159.2 E3 ubiquitin-protein ligase MIB2 isoform 4
NM_001170689.2 NP_001164160.1 E3 ubiquitin-protein ligase MIB2 isoform 5
NM_080875.5 NP_543151.4 E3 ubiquitin-protein ligase MIB2 isoform 1
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
21903422 GOA
enables ubiquitin-protein transferase activity EXP
EXP: 通过实验结果推断
31366726 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

MIB2 蛋白结构

MIB_HERC2

MIB_HERC2: Mib_herc2 (127 - 195)

ZZ

ZZ: Zinc finger, ZZ type (202 - 237)

MIB_HERC2

MIB_HERC2: Mib_herc2 (275 - 340)

Ank_5

Ank_5: Ankyrin repeats (many copies) (566 - 620)

Ank_2

Ank_2: Ankyrin repeats (3 copies) (624 - 703)

Ank_4

Ank_4: Ankyrin repeats (many copies) (716 - 769)

Ank_2

Ank_2: Ankyrin repeats (3 copies) (774 - 828)

zf-C3HC4_3

zf-C3HC4_3: Zinc finger, C3HC4 type (RING finger) (945 - 987)

zf-C3HC4_3

zf-C3HC4_3: Zinc finger, C3HC4 type (RING finger) (1024 - 1064)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1070 a.a.
蛋白主名 其他名称

E3 ubiquitin-protein ligase MIB2

RING-type E3 ubiquitin transferase MIB2

MIB2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
MIB2 Q96AX9 TBK1 Homo sapiens Q9UHD2
Anti Tag CoIP
21903422
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Left Ventricular Noncompaction

Noncompaction Cardiomyopathy

Left Ventricular Hypertrabeculation

Lvnc

Spongy Myocardium

Isolated Noncompaction Of The Ventricular Myocardium

Left Ventricular Myocardial Noncompaction Cardiomyopathy

Fetal Myocardium

Honeycomb Myocardium

Hypertrabeculation Syndrome

Left Ventricular Non-Compaction

Lvht

Non-Compaction Of The Left Ventricular Myocardium

Ventricular Noncompaction, Left

Non-Compaction Cardiomyopathy
Melanoma

Malignant Melanoma

Cutaneous Melanoma

Naevocarcinoma

Malignant Melanomas
Autosomal Recessive Alport Syndrome

Alport Syndrome, Recessive Type

Alport Syndrome, Autosomal Recessive

Alport Syndrome Autosomal Recessive

Alport Syndrome Recessive Type

Nephropathy And Deafness
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS08423 MIB2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus MIB2 MGD MGI:2679684
Rattus norvegicus MIB2 RGD RGD:1359469
Macaca mulatta MIB2 VGNC VGNC:74627
Felis catus MIB2 VGNC VGNC:80282
Canis familiaris MIB2 VGNC VGNC:43218
Bos taurus MIB2 VGNC VGNC:31456
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