2. Gene
  3. DUSP19 - dual specificity phosphatase 19 Gene

DUSP19 - dual specificity phosphatase 19 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：双特异性磷酸酶 19

种属: Homo sapiens

同用名: SKRP1; DUSP17; LMWDSP3; TS-DSP1

基因 ID: 142679 | 基因类型: protein coding

关于 DUSP19

Cytogenetic location: 2q32.1 Genomic coordinates (GRCh38): 2:183,078,747-183,100,008 (from NCBI)

This gene has 3 transcripts (splice variants), 264 orthologues and 30 paralogues. Low expression observed in reference dataset.

功能概要

双特异性磷酸酶 (DUSP) 构成了 I 型基于半胱氨酸的蛋白酪氨酸磷酸酶超家族的一个大的异质亚群。 DUSP 的特征在于它们能够使酪氨酸和丝氨酸/苏氨酸残基去磷酸化。它们被认为是关键信号通路的主要调节剂。 DUSP19 包含共有 DUSP C 端催化结构域的变体，最后一个丝氨酸残基被丙氨酸取代，并且缺少在 MKP (丝裂原活化蛋白激酶磷酸酶) 类 DUSP 中发现的 N 端 CH2 结构域 (参见 MIM 600714 ) (Patterson 等人总结，2009 [PubMed 19228121]) 。[OMIM 提供，2009 年 12 月]

Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based protein-tyrosine Phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine and serine/threonine residues. They have been implicated as major modulators of critical signaling pathways. DUSP19 contains a variation of the consensus DUSP C-terminal catalytic domain, with the last serine residue replaced by alanine, and lacks the N-terminal CH2 domain found in the MKP (mitogen-activated protein kinase Phosphatase) class of DUSPs (see MIM 600714) (summary by Patterson et al., 2009 [PubMed 19228121]).[supplied by OMIM, Dec 2009]

DUSP19 基因产物(3)

mRNA Protein Name
NM_001142314.2 NP_001135786.1 dual specificity protein phosphatase 19 isoform 2
NM_001321519.2 NP_001308448.1 dual specificity protein phosphatase 19 isoform 3
NM_080876.4 NP_543152.1 dual specificity protein phosphatase 19 isoform 1
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
21516116 GOA
enables protein tyrosine/serine/threonine phosphatase activity IDA
IDA: 通过直接分析推断
12479873 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

DUSP19 蛋白结构

DSPc

DSPc: Dual specificity phosphatase, catalytic domain (74 - 202)

  • 0
  • 100
  • 200
  • 217 a.a.
蛋白主名 其他名称

dual specificity protein phosphatase 19

SAPK pathway-regulating phosphatase 1

DUSP19 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
DUSP19 Q8WTR2 ACTB Homo sapiens P60709
Anti Tag CoIP
28514442
种属内
DUSP19 Q8WTR2 ALAS1 Homo sapiens P13196
Anti Tag CoIP
33961781
种属内
DUSP19 Q8WTR2 ALAS1 Homo sapiens P13196
Validated Y2H
25416956
种属内
DUSP19 Q8WTR2 ALAS1 Homo sapiens P13196
Y2H Array
32296183
种属内
DUSP19 Q8WTR2 ALAS1 Homo sapiens P13196
Anti Tag CoIP
28514442
种属内
DUSP19 Q8WTR2 ALAS1 Homo sapiens P13196
Y2H Array
25416956
种属内
DUSP19 Q8WTR2 ALAS1 Homo sapiens P13196
Y2H Prey Pooling
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Ichthyosis, Congenital, Autosomal Recessive 4b

Harlequin Ichthyosis

Autosomal Recessive Congenital Ichthyosis 4b

Hi

Harlequin Fetus

ARCI4B

Ichthyosis Congenita, Harlequin Fetus Type

Harlequin Type Ichthyosis

'Harlequin Fetus'

Harlequin Type Ichthyosis Congenita

Harlequin Type Ichthyosis Fetalis

Harlequin Baby Syndrome

Ichthyosis Congenita, Harlequin Type

Ichthyosis Fetalis, Harlequin Type

Ichthyosis Congenita Harlequin Fetus Type

Ichthyosis, Harlequin

Ichthyosis, Congenital, Autosomal Recessive, Type 4b
Myoclonic Epilepsy Of Lafora

Lafora Disease

Epilepsy, Progressive Myoclonic 2b

EPM2

Melf

Epilepsy, Progressive Myoclonic 2a

Epm2a

Lafora'S Disease

Lafora Body Disease

Lbd

Epilepsy, Progressive Myoclonic, 2a

Lafora Progressive Myoclonic Epilepsy

Epilepsy Progressive Myoclonic 2

Lafora Body Disorder

Pme Type 2

Progressive Myoclonic Epilepsy Type 2

Progressive Myoclonus Epilepsy Type 2

Epilepsy, Progressive Myoclonic 2

Epm2b

Ld

Progressive Myoclonic Epilepsy 2

Progressive Myoclonic Epilepsy 2a

Progressive Myoclonic Epilepsy 2b

Progressive Myoclonic Epilepsy Lafora Type

Epilepsy, Myoclonic, Of Lafora
Cowden Syndrome

Cowden Disease

Multiple Hamartoma Syndrome

Cowden'S Disease

Lhermitte-Duclos Disease

Cd

Cs

Mham

Dysplastic Gangliocytoma Of Cerebellum

Cowden'S Syndrome

Hamartoma Syndrome, Multiple
Skin Disease

Skin Diseases

Genodermatosis

Abnormality Of The Skin

Skin Diseases, Genetic

Skin And Subcutaneous Tissue Disease

Dermatologic Disorders
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS04059 DUSP19 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus DUSP19 VGNC VGNC:61665
Canis familiaris DUSP19 VGNC VGNC:40131
Bos taurus DUSP19 VGNC VGNC:28254
Mus musculus DUSP19 MGD MGI:1915332
Rattus norvegicus DUSP19 RGD RGD:1307457
Macaca mulatta DUSP19 VGNC VGNC:99357
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