2. Gene
  3. Fxn - frataxin Gene

Fxn - frataxin Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: FA; X25; FARR; Frda

基因 ID: 14297 | 基因类型: protein coding

关于 Fxn

功能概要

Predicted to enable several functions, including 2 iron, 2 sulfur cluster binding activity; ferroxidase activity; and iron ion binding activity. Acts upstream of or within several processes, including adult walking behavior; negative regulation of organ growth; and proprioception. Located in mitochondrion. Is expressed in several structures, including brain; cartilage condensation; heart; hemolymphoid system; and lower jaw incisor. Used to study Friedreich ataxia. Human ortholog(s) of this gene implicated in Friedreich ataxia; Friedreich ataxia 1; and type 2 diabetes mellitus. Orthologous to human FXN (frataxin). [provided by Alliance of Genome Resources, Apr 2022]

Fxn 基因产物(1)

mRNA Protein Name
NM_008044.3 NP_032070.1 frataxin, mitochondrial precursor
基因本体论
  • 生物过程
  • 细胞组分
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in [4Fe-4S] cluster assembly IDA
IDA: 通过直接分析推断
25597503 MGI
acts upstream of or within adult walking behavior IMP
IMP: 通过突变表型推断
9405681 MGI
acts upstream of or within aerobic respiration IMP
IMP: 通过突变表型推断
9405681 MGI
acts upstream of or within embryo development ending in birth or egg hatching IMP
IMP: 通过突变表型推断
10767347 MGI
acts upstream of or within intracellular iron ion homeostasis IMP
IMP: 通过突变表型推断
9405681 MGI
acts upstream of or within iron-sulfur cluster assembly IMP
IMP: 通过突变表型推断
16278235 MGI
acts upstream of or within mitochondrion organization IMP
IMP: 通过突变表型推断
9405681 MGI
acts upstream of or within muscle cell cellular homeostasis IMP
IMP: 通过突变表型推断
9405681 MGI
acts upstream of or within negative regulation of multicellular organism growth IMP
IMP: 通过突变表型推断
17404227 MGI
acts upstream of or within negative regulation of organ growth IMP
IMP: 通过突变表型推断
9405681 MGI
acts upstream of organ growth IMP
IMP: 通过突变表型推断
9405681 MGI
acts upstream of or within oxidative phosphorylation IMP
IMP: 通过突变表型推断
16278235 MGI
acts upstream of or within proprioception IMP
IMP: 通过突变表型推断
11175786 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of mitochondrial [2Fe-2S] assembly complex IDA
IDA: 通过直接分析推断
21298097 MGI
located in mitochondrion IDA
IDA: 通过直接分析推断
17597094 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

frataxin, mitochondrial

Friedreich ataxia

重组 Fxn 蛋白

目录号 产品名 蛋白编号 纯度
HY-P71735 FXN Protein, Mouse (P.pastoris, His) O35943 (L78-T207) ≥95%
HY-P72199 FXN Protein, Mouse (His) O35943 (L78-T207) ≥95%

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS05162 FXN Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-149737 FXn / 否
HY-158740 1(R)-(Trifluoromethyl)oleyl alcohol Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Fxn NCBI NCBI:2395
Macaca fascicularis Fxn NCBI NCBI:102120656
Rattus norvegicus Fxn NCBI NCBI:499335
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