Tlr3 - toll-like receptor 3 Gene

中文名称：Toll样受体 3

种属: Mus musculus

关于 Tlr3

功能概要

预测该基因编码的蛋白可实现双链 RNA 结合活性；相同的蛋白质结合活性；和信号受体活性。涉及几个进程，包括JNK级联；血管生成的正向调节；和细胞因子产生的正调节。作用于多个过程的上游或内部，包括对 NF-kappaB 转录因子活性的正向调节；细胞内信号转导的正向调节；和调节细胞因子的产生。预测位于细胞表面和细胞质中。预计是质膜的组成部分。在大脑中表达；大脑皮层；大脑皮层脑室层；前脑;和颌下腺原基。该基因的人类直系同源基因与多种疾病有关，包括乙型肝炎；丙型肝炎;人类免疫缺陷病毒传染病；肝硬化;和 1 型糖尿病。与人类 TLR3（toll 样受体 3）同源。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable double-stranded RNA binding activity; identical protein binding activity; and signaling receptor activity. Involved in several processes, including JNK cascade; positive regulation of angiogenesis; and positive regulation of cytokine production. Acts upstream of or within several processes, including positive regulation of NF-kappaB transcription factor activity; positive regulation of intracellular signal transduction; and regulation of cytokine production. Predicted to be located in cell surface and cytoplasm. Predicted to be integral component of plasma membrane. Is expressed in brain; cerebral cortex; cerebral cortex ventricular layer; forebrain; and submandibular gland primordium. Human ortholog(s) of this gene implicated in several diseases, including hepatitis B; hepatitis C; human immunodeficiency virus infectious disease; liver cirrhosis; and type 1 diabetes mellitus. Orthologous to human TLR3 (toll like receptor 3). [provided by Alliance of Genome Resources, Apr 2022]