CSH2 - chorionic somatomammotropin hormone 2 Gene

中文名称：绒毛膜促生长激素 2

种属: Homo sapiens

同用名: PL; CSB; CS-2; GHB1; hCS-B

基因 ID: 1443 | 基因类型: protein coding

关于 CSH2

Cytogenetic location: 17q23.3 Genomic coordinates (GRCh38): 17:63,872,012-63,873,729 (from NCBI)

This gene has 7 transcripts (splice variants), 206 orthologues and 5 paralogues. Restricted expression toward placenta (RPKM 5535.3).

功能概要

由该基因编码的蛋白质是生长激素/催乳素激素家族的成员，在生长控制中起着重要作用。该基因位于 17 号染色体上的生长激素位点，与其他四个转录方向相同的相关基因一起；一种被认为是由一系列基因复制进化而来的排列。虽然这五个基因具有非常高的序列同一性，但它们在不同组织中有选择性地表达。选择性剪接会产生五种生长激素中每一种的额外亚型。这个特殊的家族成员主要在胎盘中表达并利用多个转录起始位点。绒毛膜促生长素激素 1 和 2 的相同成熟蛋白的表达在发育过程中被上调，而 1 与 2 的比例随足月增加。结构和表达差异为发育调控和组织特异性提供了途径。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is a member of the somatotropin/Prolactin family of Hormones and plays an important role in growth control. The gene is located at the growth hormone locus on chromosome 17 along with four Other related genes in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. Although the five genes share a remarkably high degree of sequence identity, they are expressed selectively in different tissues. Alternative splicing generates additional isoforms of each of the five growth Hormones. This particular family member is expressed mainly in the placenta and utilizes multiple transcription initiation sites. Expression of the identical mature proteins for chorionic somatomammotropin Hormones 1 and 2 is upregulated during development, while the ratio of 1 to 2 increases by term. Structural and expression differences provide avenues for developmental regulation and tissue specificity. [provided by RefSeq, Jul 2008]

CSH2 基因产物(3)

mRNA	Protein	Name
NM_020991.4	NP_066271.1	chorionic somatomammotropin hormone 2 isoform 1 precursor
NM_022644.3	NP_072170.1	chorionic somatomammotropin hormone 2 isoform 2 precursor
NM_022645.2	NP_072171.1	chorionic somatomammotropin hormone 2 isoform 3 precursor

基因本体论

分子功能
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	32296183	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in endoplasmic reticulum	IDA IDA: 通过直接分析推断	6930851	GOA
located in vesicle	IDA IDA: 通过直接分析推断	6930851	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CSH2 蛋白结构

Hormone_1

0
100
200
217 a.a.

蛋白主名

其他名称

chorionic somatomammotropin hormone 2

choriomammotropin

CSH2 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	CSH2	P0DML3	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183
种属内	CSH2	P0DML3	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
种属内	CSH2	P0DML3	MEOX2	Homo sapiens	Q6FHY5	Validated Y2H	32296183
种属内	CSH2	P0DML3	SGTB	Homo sapiens	Q96EQ0	Y2H Prey Pooling	32296183
种属内	CSH2	P0DML3	SGTB	Homo sapiens	Q96EQ0	Validated Y2H	32296183
种属内	CSH2	P0DML3	SGTB	Homo sapiens	Q96EQ0	Y2H Array	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

CSH2 抗体

目录号	产品名	应用	反应物种
HY-P81446	Placental lactogen Antibody (YA1191)	IHC-P	Human

关联疾病

疾病名称

别名

Choriocarcinoma

Chorioepithelioma

Epithelioid Trophoblastic Tumor

Trophoblastic Tumor, Epithelioid

Testicular Trophoblastic Tumor

Choriocarcinoma Of Ovary

Ovarian Choriocarcinoma

Gestational Choriocarcinoma

Gestational Chorionepithelioma

Molar Pregnancy With Choriocarcinoma

Non-Gestational Choriocarcinoma

Choriocarcinoma, Non-Gestational

Placental Site Trophoblastic Tumor

Trophoblastic Tumor Placental Site	Trophoblastic Tumor, Placental Site
Placental Site Trophoblastic Tumour	Placental-Site Gestational Trophoblastic Neoplasm
Placenta Neoplasm	Psst
Deciduoma	Placental Cancer
Primary Malignant Neoplasm Of Placenta

Persistent Fetal Circulation Syndrome

Persistent Fetal Circulation	Fetal Circulation
Persistent Pulmonary Hypertension Of The Newborn	Congenital Alveolar Capillary Dysplasia With Misalignment Of Pulmonary Veins
Persistent Foetal Circulation	Persistent Foetal Circulation Syndrome
Pfc - [Persistent Fetal Circulation] Syndrome	Pphn - [Persistent Pulmonary Hypertension Of The Newborn]
Newborn Pulmonary Hypertension	Primary Pulmonary Hypertension Of Newborn

Non-Gestational Ovarian Choriocarcinoma

Gestational Ovarian Choriocarcinoma

Placental Choriocarcinoma

Choriocarcinoma Of The Placenta

Supine Hypotensive Syndrome

Maternal Hypotension Syndrome	Antepartum Maternal Hypotension Syndrome
Postpartum Maternal Hypotension Syndrome	Maternal Hypotension Syndrome, Antepartum Condition Or Complication
Maternal Hypotension Syndrome, Postpartum Condition Or Complication	Maternal Hypotension Syndrome, Unspecified Trimester

Rete Ovarii Benign Neoplasm

Rete Ovarii Adenoma

Adenoma Of Rete Ovarii

Trophoblastic Neoplasm

Trophoblastic Tumor

Trophoblastic Neoplasms

Corpus Luteum Cyst

Cystic Corpus Luteum	Luteal Cystic Ovary Disease
Lutein Cyst	Granulosa Lutein Cyst

Mixed Germ Cell Cancer

Mixed Germ Cell Tumor	Mixed Germ Cell Neoplasm
Mixed Germ Cell Tumour	Mixed Teratoma And Seminoma

Gestational Trophoblastic Neoplasm

Hydatidiform Mole	Molar Pregnancy
Gestational Trophoblastic Neoplasia	Gestational Trophoblastic Tumor
Gtn	Gestational Trophoblastic Disease
Gestational Trophoblastic Neoplasms	Hydatidiform Mole, Recurrent, 1
Hydatidiform Mole Benign	Trophoblastic Disease
Trophoblastic Disease Nos	Trophoblastic Disorder
Vesicular Mole Nos	Vesicular Mole
Hydatidiform Mole Nos

Rh Isoimmunization

Rh Incompatibility Affecting Management Of Mother

Placenta Disease

Placenta Diseases	Placenta Disorder
Pregnancy Complications	Placenta Disorders

Immunodeficiency 36

IMD36	Activated Phosphoinositide 3-Kinase Delta Syndrome 2
Immunodeficiency, Type 36

Ectopic Pregnancy

Eccyesis	Pregnancy Ectopic
Pregnancy, Ectopic	Ectopic Pregnancies
Extrauterine Gestation Or Pregnancy	Extrauterine Pregnancy
Ep - [Ectopic Pregnancy]	Ectopic Mole
Aborted Ectopic Pregnancy	Ruptured Ectopic Pregnancy

Pre-Eclampsia

Preeclampsia	Gestational Hypertension
Hypertension Induced By Pregnancy	Pre-Eclamptic Toxaemia
Pregnancy Associated Hypertension	Proteinuric Hypertension Of Pregnancy
Hypertension, Pregnancy-Induced, Susceptibility To	Preeclampsia/Eclampsia
Pregnancy Toxemia	Toxaemia Of Pregnancy
Gestational Proteinuric Hypertension	Pregnancy-Induced Hypertension
Toxemia Of Pregnancy	Preeclampsia, Susceptibility To
Transient Hypertension Of Pregnancy	Gestational [Pregnancy-Induced] Hypertension Without Significant Proteinuria
Gestational Hypertension Nos	Mild Proteinuric Hypertension Of Pregnancy
Pih - [Pregnancy-Induced Hypertension]	Pregnancy-Induced Hypertension Nos
Gestational [Pregnancy-Induced] Hypertension With Significant Proteinuria	Pe - [Pre-Eclampsia]
Pre-Eclampsia Nos	Pre-Eclamptic Nos
Pregnancy Pre-Eclampsia	Puerperal Pre-Eclampsia
Pre-Eclampsia Toxaemia	Toxaemia In Pregnancy
Pet - [Pre-Eclamptic Toxaemia]	Maternal Toxaemia

Noonan Syndrome With Multiple Lentigines

Leopard Syndrome	Multiple Lentigines Syndrome
Moynahan Syndrome	Cardiomyopathic Lentiginosis
Progressive Cardiomyopathic Lentiginosis	Cardio-Cutaneous Syndrome
Lentiginosis Profusa	Capute-Rimoin-Konigsmark-Esterly-Richardson Syndrome
Generalized Lentiginosis	Gorlin Syndrome Ii
Lentiginosis Profusa Syndrome	Lentigines, Electrocardiographic Conduction Abnormalities, Ocular Hypertelorism, Pulmonic Stenosis, Abnormal Genitalia, Retardation Of Growth, Deafnes
Diffuse Lentiginosis	Nsml
Familial Multiple Lentigines Syndrome	Alopecia-Epilepsy-Intellectual Disability Syndrome, Moynahan Type
Progressive Cardiomyopathic Lentiginosis Syndrome	Alopecia Epilepsy Oligophrenia Syndrome Of Moynahan

Rasopathy

Ras/Mitogen-Activated Protein Kinase Syndrome

Germ Cell And Embryonal Cancer

Germ Cell And Embryonal Neoplasm

Juvenile Myelomonocytic Leukemia

Leukemia, Juvenile Myelomonocytic	JMML
Leukemia, Juvenile Myelomonocytic, Somatic	Juvenile Chronic Myelomonocytic Leukemia
Juvenile Chronic Myelogenous Leukemia	Leukemia, Myelomonocytic, Juvenile
Juvenile Myelomonocytic Leukaemia Without Mention Of Remission

Noonan Syndrome 1

Noonan Syndrome	NS1
Male Turner Syndrome	Female Pseudo-Turner Syndrome
Turner Phenotype With Normal Karyotype	Noonan Syndrome With Pigmented Villonodular Synovitis
Turner'S Phenotype, Karyotype Normal	Familial Turner Syndrome
Noonan'S Syndrome	Noonan-Ehmke Syndrome
Ns	Pseudo-Ullrich-Turner Syndrome
Turner Syndrome In Female With X Chromosome	Turner-Like Syndrome
Ullrich-Noonan Syndrome	Noonan-Like/Multiple Giant Cell Lesion Syndrome
Noonan Syndrome-Like Disorder With Multiple Giant Cell Lesions	Pterygium Colli Syndrome
Noonan Syndrome, Type 1	Turner Syndrome, Male

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS03237	CSH2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	CSH2	MGD	MGI:95707

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

CSH2 - chorionic somatomammotropin hormone 2 Gene

关于 CSH2

功能概要

CSH2 基因产物(3)

CSH2 蛋白结构

CSH2 蛋白互作信息

CSH2 抗体

关联疾病

直系同源

热门区域

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CSH2 - chorionic somatomammotropin hormone 2 Gene

关于 CSH2

功能概要

CSH2 基因产物(3)

CSH2 蛋白结构

CSH2 蛋白互作信息

CSH2 抗体

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z