PIK3R6 - phosphoinositide-3-kinase regulatory subunit 6 Gene

中文名称：磷酸肌醇 3 激酶调节亚基 6

种属: Homo sapiens

同用名: C17orf38; HsT41028; p87PIKAP; p84 PIKAP; p87(PIKAP)

关于 PIK3R6

功能概要

磷酸肌醇 3-激酶 γ 是一种脂质激酶，可产生脂质第二信使磷脂酰肌醇 3,4,5-三磷酸。该激酶由一个催化亚基和几个调节亚基之一组成，主要由 G 蛋白偶联受体激活。该基因编码一个调节亚基，与磷酸肌醇 3 激酶、调节亚基 5 基因远相关，后者位于 7 号染色体上与该基因相邻的位置。小鼠中的直系同源蛋白与催化亚基和 G ( beta/gamma) ，并介导 G 蛋白偶联受体下游激酶亚基的激活。可变剪接导致多个转录本变体。[RefSeq 提供，2014 年 2 月]

Phosphoinositide 3-kinase gamma is a lipid kinase that produces the lipid second messenger phosphatidylinositol 3,4,5-trisphosphate. The kinase is composed of a catalytic subunit and one of several regulatory subunits, and is chiefly activated by G protein-coupled receptors. This gene encodes a regulatory subunit, and is distantly related to the phosphoinositide-3-kinase, regulatory subunit 5 gene which is located adjacent to this gene on chromosome 7. The orthologous protein in the mouse binds to both the catalytic subunit and to G(beta/gamma), and mediates activation of the kinase subunit downstream of G protein-coupled receptors. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]