2. Gene
  3. PDE3B - phosphodiesterase 3B Gene

PDE3B - phosphodiesterase 3B Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：磷酸二酯酶 3B

种属: Homo sapiens

同用名: HcGIP1; cGIPDE1

基因 ID: 5140 | 基因类型: protein coding

关于 PDE3B

Cytogenetic location: 11p15.2 Genomic coordinates (GRCh38): 11:14,643,804-14,872,044 (from NCBI)

This gene has 5 transcripts (splice variants), 204 orthologues and 20 paralogues. Biased expression in fat (RPKM 53.0), lymph node (RPKM 8.6) and 12 other tissues.

功能概要

启用 3',5'-环状核苷酸磷酸二酯酶活性。参与血管生成的负调节；细胞粘附的负调节；和脂质分解代谢过程的负调节。位于膜内。部分胍基核苷酸交换因子复合物。 [由基因组资源联盟提供，2022 年 4 月]

Enables 3',5'-cyclic-nucleotide phosphodiesterase activity. Involved in negative regulation of angiogenesis; negative regulation of cell adhesion; and negative regulation of lipid catabolic process. Located in membrane. Part of guanyl-nucleotide exchange factor complex. [provided by Alliance of Genome Resources, Apr 2022]

PDE3B 基因产物(3)

mRNA Protein Name
NM_000922.4 NP_000913.2 cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B isoform 2
NM_001363569.2 NP_001350498.1 cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B isoform 3
NM_001363570.2 NP_001350499.1 cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables 3',5'-cyclic-AMP phosphodiesterase activity IDA
IDA: 通过直接分析推断
14592490 GOA
enables 3',5'-cyclic-nucleotide phosphodiesterase activity EXP
EXP: 通过实验结果推断
8562305 GOA
enables 3',5'-cyclic-nucleotide phosphodiesterase activity IDA
IDA: 通过直接分析推断
14592490 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
17255105 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of angiogenesis IMP
IMP: 通过突变表型推断
21393242 GOA
involved in negative regulation of cell adhesion IMP
IMP: 通过突变表型推断
17884339 GOA
involved in negative regulation of lipid catabolic process IMP
IMP: 通过突变表型推断
11641262 GOA
involved in regulation of angiogenesis IMP
IMP: 通过突变表型推断
21840392 GOA
involved in regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
IMP: 通过突变表型推断
21840392 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of guanyl-nucleotide exchange factor complex IDA
IDA: 通过直接分析推断
17884339 GOA
located in membrane IDA
IDA: 通过直接分析推断
18586889 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PDE3B 蛋白结构

PDEase_I

PDEase_I: 3'5'-cyclic nucleotide phosphodiesterase (806 - 1002)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1112 a.a.
蛋白主名 其他名称

cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B

cGMP-inhibited 3',5'-cyclic phosphodiesterase B

CGI-PDE B

PDE3B 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
PDE3B Q13370 PIK3CG Homo sapiens P48736
Anti Bait CoIP
21393242
种属内
PDE3B Q13370 RAPGEF3 Homo sapiens O95398
Peptide Array
21393242
种属内
PDE3B Q13370 RAPGEF3 Homo sapiens O95398
Imaging
21393242
种属内
PDE3B Q13370 RAPGEF3 Homo sapiens O95398
Anti Bait CoIP
21393242
种属内
PDE3B Q13370 RAPGEF3 Homo sapiens O95398
Pull Down
21393242
种属内
PDE3B Q13370 PIK3R6 Homo sapiens Q5UE93
Anti Bait CoIP
21393242
种属内
PDE3B Q13370 PIK3R6 Homo sapiens Q5UE93
Anti Tag CoIP
21393242
种属内
PDE3B Q13370 LNX1 Homo sapiens Q8TBB1
Validated Y2H
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Pelizaeus-Merzbacher Disease

PMD

HLD1

Pelizaeus-Merzbacher Brain Sclerosis

Leukodystrophy, Hypomyelinating, 1

Diffuse Familial Brain Sclerosis

Pelizaeus Merzbacher Brain Sclerosis

Sudanophilic Leukodystrophy, Paelizeus-Merzbacher Type

Cockayne-Pelizaeus-Merzbacher Disease

Hypomyelinating Leukodystrophy 1

Leukodystrophy, Sudanophilic

Pelizaeus Merzbacher Disease

Hypomyelinating Leukodystrophy, 1

Sudanophilic Leukodystrophy

Pelizaeus-Merzbacher Disease, Connatal Form

Connatal Pmd

Pelizaeus-Merzbacher Disease Type Ii

Severe Pmd

Null Syndrome

Plp1 Null Syndrome

Pelizaeus-Merzbacher Disease, Null Syndrome

Brain Sclerosis Diffuse Familial

Sudanophilic Leukodystrophy Paelizeus-Merzbacher Type

Leukodystrophy Hypomyelinating 1

Diffuse Cerebral Sclerosis Of Schilder
Impotence

Erectile Dysfunction

Sexual Impotence

Erectile Dysfunction Adverse Event
Brachydactyly
Type 2 Diabetes Mellitus

Insulin Resistance

NIDDM

Type 2 Diabetes

Diabetes Mellitus, Non-Insulin-Dependent

T2D

Noninsulin-Dependent Diabetes Mellitus

Diabetes Mellitus, Type Ii

Maturity-Onset Diabetes

Insulin Resistance, Severe, Digenic

Diabetes Mellitus, Type 2

Diabetes Mellitus, Noninsulin-Dependent

Diabetes Mellitus, Noninsulin-Dependent, Association With

Diabetes Mellitus, Noninsulin-Dependent, Late Onset

Hypertension, Insulin Resistance-Related, Susceptibility To

Insulin Resistance, Susceptibility To

Non-Insulin-Dependent Diabetes Mellitus

Type Ii Diabetes Mellitus

Adult-Onset Diabetes Mellitus

Maturity-Onset Diabetes Mellitus

Diabetes Mellitus Type 2

Type Ii Diabetes

Type 2 Diabetes Mellitus, Susceptibility To

Diabetes, Type 2

Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To

Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To

Diabetes Mellitus, Type 2, Susceptibility To

Diabetes Mellitus, Noninsulin-Dependent, 2

Diabetes Mellitus, Type Ii, Susceptibility To

Hypertension, Insulin Resistance-Related

Adult-Onset Diabetes

Aodm

Diabetes Mellitus, Adult-Onset

Diabetes Mellitus Type Ii

Diabetes Mellitus Type 2, Susceptibility To

Diabetes, Type Ii, Susceptibility To

Diabetes Type 2

Diabetes Mellitus

Adult Onset Diabetes

Maturity Onset Diabetes

Nonketotic Diabetes

Non-Insulin Dependent Diabetes Mellitus

T2dm - [Type 2 Diabetes Mellitus]

Niddm - [Non Insulin Dependent Diabetes Mellitus]

Dm2

Dm Type Ii

Diabetic Type 2

Insulin Requiring Type 2 Diabetes

Noninsulin Dependent Diabetes

Non-Insulin-Dependent Diabetes Mellitus Without Complications

Diabetes Due To Insulin Secretory Defect

Diabetes Mellitus Due To Insulin Secretory Defect

Non-Insulin-Dependent Diabetes Of The Young

Senile Diabetes

Nonketotic Hyperglycaemia

Stable Diabetes
Asthma

Chronic Obstructive Asthma

Asthma, Diminished Response To Antileukotriene Treatment In

Bronchial Hyperreactivity

Asthma, Susceptibility To

Asthma, Bronchial

Asthma, Protection Against

Asthma, Nocturnal, Susceptibility To

Nocturnal Asthma

Asthma-Related Traits

Asthma-Related Traits, Susceptibility To

Asthma, Nocturnal

Chronic Obstructive Asthma With Acute Exacerbation

Chronic Obstructive Asthma With Status Asthmaticus

Exercise Induced Asthma

Exercise-Induced Asthma

Bronchial Asthma

Asthma, Exercise-Induced

Idiosyncratic Asthma

Unspecified Asthma With Acute Exacerbation

Asthma, Unspecified, With Stated Status Asthmaticus

Status Asthmaticus Nos

Acute Severe Asthma

Acute Severe Bronchial Asthma

Status Asthma

Status Post Asthmaticus
Diabetes Mellitus

Diabetes
Leukemia, Chronic Lymphocytic

Chronic Lymphocytic Leukemia

B-Cell Chronic Lymphocytic Leukemia

CLL

B-Cell Chronic Lymphoid Leukemia

Chronic Lymphatic Leukemia

Chronic Lymphocytic Leukaemia

Lymphoplasmacytic Leukemia

Small Lymphocytic Lymphoma

Leukemia, Chronic Lymphatic

B-Cell Chronic Lymphocytic Leukaemia

Chronic Lymphatic Leukaemia

Lymphoplasmacytic Leukaemia

B Cell Chronic Lymphocytic Leukemia

Chronic B-Cell Lymphocytic Leukemia

Leukemia, Lymphocytic, Chronic

B-Cll

Chronic Lymphoid Leukemia

Leukemia Lymphocytic Chronic

Lymphoma Small Lymphocytic

Leukemia, Lymphocytic, Chronic, B-Cell
Body Mass Index Quantitative Trait Locus 11

OBESITY

Obesity, Susceptibility To

Leanness, Inherited

Obesity, Susceptibility To, Bmiq11

Obesity, Mild, Early-Onset

Obesity, Association With

Obesity, Early-Onset, Susceptibility To

Obesity, Severe

Obesity, Severe, And Type Ii Diabetes

Obesity, Late-Onset

Obesity , Susceptibility To

BMIQ11

Obesity Bmiq11

Obesity, Early-Onset

Simple Obesity Nos

Excess Fat

Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified

Adiposis
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Clinical Phase
生物活性分子 (2)
目录号 产品名 作用方式
纯度 Phase
HY-U00186 K134 Inhibitor 99.84% Phase 2
HY-145924 BAY 2666605 Inhibitor 99.74% Phase 1
Pre-clinical Phase
生物活性分子 (5)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-101312 Cilostamide Inhibitor 99.64% 否
HY-136350 BRD9500 Modulator 99.46% 否
HY-136350B (S)-BRD9500 99.67% 否
HY-163285 PDE3B-IN-1 Inhibitor / 否
HY-RS10219 PDE3B Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus PDE3B VGNC VGNC:32675
Felis catus PDE3B VGNC VGNC:68757
Macaca mulatta PDE3B VGNC VGNC:75914
Mus musculus PDE3B MGD MGI:1333863
Canis familiaris PDE3B VGNC VGNC:52287
Rattus norvegicus PDE3B RGD RGD:61943
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