2. Gene
  3. Pdia3 - protein disulfide isomerase associated 3 Gene

Pdia3 - protein disulfide isomerase associated 3 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：蛋白质二硫键异构酶相关3

种属: Mus musculus

同用名: Erp; PDI; Plca; 58kDa; ERp57; ERp60; ERp61; Grp58; PDI-Q2; PI-PLC; PLC[a]

基因 ID: 14827 | 基因类型: protein coding

关于 Pdia3

Chromosome 2: 121,244,256-121,269,168 forward strand.GRCm39:CM000995.3

This gene has 4 transcripts (splice variants), 225 orthologues, 13 paralogues and is associated with 10 phenotypes. Ubiquitous expression in placenta adult (RPKM 23.6), ovary adult (RPKM 132.6) and 28 other tissues.

功能概要

预计该基因编码的蛋白具有多种功能，包括相同的蛋白质结合活性；蛋白质二硫键异构酶活性；和蛋白质二硫化物还原酶（谷胱甘肽）活性。作用于细胞对白细胞介素 7 的反应的上游或内部，并积极调节外源性凋亡信号通路。位于细胞表面和内质网。以多种结构表达，包括消化系统；脑;泌尿生殖系统；淋巴系统腺体；和肢体部分。该基因的人类直系同源物与自身免疫性肝炎有关。与人类 PDIA3（蛋白质二硫键异构酶家族 A 成员 3）同源。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable several functions, including identical protein binding activity; protein disulfide isomerase activity; and protein-disulfide reductase (glutathione) activity. Acts upstream of or within cellular response to interleukin-7 and positive regulation of extrinsic apoptotic signaling pathway. Located in cell surface and endoplasmic reticulum. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and limb segment. Human ortholog(s) of this gene implicated in autoimmune hepatitis. Orthologous to human PDIA3 (protein disulfide isomerase family A member 3). [provided by Alliance of Genome Resources, Apr 2022]

Pdia3 基因产物(1)

mRNA Protein Name
NM_007952.2 NP_031978.2 protein disulfide-isomerase A3 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
21093319 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within cellular response to interleukin-7 IDA
IDA: 通过直接分析推断
29581031 MGI
acts upstream of extrinsic apoptotic signaling pathway IMP
IMP: 通过突变表型推断
15858817 MGI
acts upstream of or within platelet aggregation IMP
IMP: 通过突变表型推断
28576878 MGI
acts upstream of or within positive regulation of extrinsic apoptotic signaling pathway IMP
IMP: 通过突变表型推断
15858817 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cell surface IDA
IDA: 通过直接分析推断
19995400 MGI
located in endoplasmic reticulum IDA
IDA: 通过直接分析推断
9493907 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Pdia3 蛋白结构

ER_PDI_fam

ER_PDI_fam: cl36828 (25 - 486)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 505 a.a.
蛋白主名 其他名称

protein disulfide-isomerase A3

58 kDa glucose-regulated protein

58 kDa microsomal protein

ER protein 57

ER protein 60

disulfide isomerase ER-60

endoplasmic reticulum protein

endoplasmic reticulum resident protein 57

endoplasmic reticulum resident protein 60

glucose regulated protein, 58 kDa

p58

phospholipase C, alpha

相关产品

Pre-clinical Phase
生物活性分子 (8)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-N0177 Diosgenin Inhibitor 99.35% 否
HY-100432 LOC14 ≥98.0% 否
HY-122895 E64FC26 98.10% 否
HY-122895A (E/Z)-E64FC26 98.09% 否
HY-151286 Antitumor agent-73 Inhibitor / 否
HY-RS10266 PDIA3 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS10267 Pdia3 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS10268 Pdia3 Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Pdia3 NCBI NCBI:2923
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