DUSP18 - dual specificity phosphatase 18 Gene

中文名称：双特异性磷酸酶 18

种属: Homo sapiens

同用名: DSP18; DUSP20; LMWDSP20

关于 DUSP18

功能概要

双特异性磷酸酶 (DUSP) 构成了 I 型基于半胱氨酸的蛋白酪氨酸磷酸酶超家族的一个大的异质亚群。 DUSP 的特征在于它们能够使酪氨酸和丝氨酸/苏氨酸残基去磷酸化。它们被认为是关键信号通路的主要调节剂。 DUSP18 包含一致的 DUSP C 端催化结构域，但缺少在 MKP (丝裂原活化蛋白激酶磷酸酶) 类 DUSP 中发现的 N 端 CH2 结构域 (参见 MIM 600714) (Patterson 等人总结，2009 [PubMed 19228121 ]) .[OMIM 提供，2009 年 12 月]

Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based protein-tyrosine Phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine and serine/threonine residues. They have been implicated as major modulators of critical signaling pathways. DUSP18 contains the consensus DUSP C-terminal catalytic domain but lacks the N-terminal CH2 domain found in the MKP (mitogen-activated protein kinase Phosphatase) class of DUSPs (see MIM 600714) (summary by Patterson et al., 2009 [PubMed 19228121]).[supplied by OMIM, Dec 2009]