ADRA2B - adrenoceptor alpha 2B Gene

中文名称：肾上腺素受体α2B

种属: Homo sapiens

同用名: FAME2; ADRA2L1; ADRARL1; ADRA2RL1; ALPHA2BAR; alpha-2BAR

基因 ID: 151 | 基因类型: protein coding

关于 ADRA2B

Cytogenetic location: 2q11.2 Genomic coordinates (GRCh38): 2:96,112,876-96,116,571 (from NCBI)

This gene has 1 transcript (splice variant), 222 orthologues, 18 paralogues and is associated with 2 phenotypes.

功能概要

这种无内含子的基因编码一种七次跨膜蛋白。这种蛋白质是 G 蛋白偶联受体亚家族的成员，可调节中枢神经系统中交感神经和肾上腺素能神经元的神经递质释放。[RefSeq 提供，2014 年 4 月]

This intronless gene encodes a seven-pass transmembrane protein. This protein is a member of a subfamily of G protein-coupled receptors that regulate neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. [provided by RefSeq, Apr 2014]

ADRA2B 基因产物(1)

mRNA	Protein	Name
NM_000682.7	NP_000673.2	alpha-2B adrenergic receptor

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables alpha2-adrenergic receptor activity	IDA IDA: 通过直接分析推断	17215105	GOA
enables epinephrine binding	IDA IDA: 通过直接分析推断	17215105	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	16531006	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in G protein-coupled receptor signaling pathway	IDA IDA: 通过直接分析推断	17215105	GOA
involved in activation of protein kinase B activity	IDA IDA: 通过直接分析推断	17215105	GOA
involved in adrenergic receptor signaling pathway	IDA IDA: 通过直接分析推断	17215105	GOA
involved in positive regulation of MAPK cascade	IDA IDA: 通过直接分析推断	17215105	GOA
involved in positive regulation of neuron differentiation	IDA IDA: 通过直接分析推断	17215105	GOA
involved in receptor transactivation	IDA IDA: 通过直接分析推断	17215105	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cell surface	IDA IDA: 通过直接分析推断	27901063	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ADRA2B 蛋白结构

7tm_1

0
100
200
300
400
447 a.a.

蛋白主名

其他名称

alpha-2B adrenergic receptor

ADRA2B adrenergic, alpha-2B-, receptor

ADRA2B 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	ADRA2B	P18089	RAB26	Homo sapiens	Q9ULW5	Pull Down	23105096

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Familial Adult Myoclonic Epilepsy

Benign Adult Familial Myoclonus Epilepsy	Bafme
Benign Adult Familial Myoclonic Epilepsy	Fame
Familial Cortical Myoclonic Tremor And Epilepsy	Fcmte
Adcme	Autosomal Dominant Cortical Myoclonus And Epilepsy
Fam	Epilepsy, Myoclonic, Familial Adult
Epilepsy, Myoclonic, Benign Adult Familial, Type 2

Mild Cognitive Impairment

Epilepsy, Familial Adult Myoclonic, 2

FAME2	Benign Adult Familial Myoclonic Epilepsy 2
Bafme2	Fcmte2
Adcme	Cortical Myoclonic Tremor With Epilepsy, Familial, 2
Cortical Myoclonus And Epilepsy, Autosomal Dominant	Familial Adult Myoclonic Epilepsy 2
Epilepsy, Myoclonic, Benign Adult Familial, Type 2	Autosomal Dominant Cortical Myoclonus And Epilepsy
Familial Cortical Myoclonic Tremor And Epilepsy 2	Epilepsy, Myoclonic, Familial Adult, Type 2

Resting Heart Rate, Variation In

Resting Heart Rate	Rhr
Resting Heart Rate, Variation

Coronary Restenosis

Hypertension, Essential

Essential Hypertension	Hypertension
High Blood Pressure	Hypertension, Essential, Susceptibility To
Hypertensive Disease	Primary Hypertension
EHT	Hypertension, Salt-Sensitive Essential, Susceptibility To
Hyperpiesia	Idiopathic Hypertension
Hypertensive Disorder	Hypertension, Essential, Susceptibility To, 3
Hypertension, Essential 3	Hypertension, Essential, Salt-Sensitive
Hypertension, Essential, Susceptibility To, 6	Hypertension, Essential 6
Hypertension, Salt-Sensitive Essential	Hypertension, Susceptibility To
Hypertension, Essential, Susceptibility To, 4	Hypertension, Essential 4
Hypertension, Essential, Susceptibility To, 2	Hypertension, Essential 2
Hypertension, Essential, Susceptibility To, 1	Hypertension, Essential 1
Hypertension, Essential, Susceptibility To, 5	Hypertension, Essential 5
Htn	Vascular Hypertensive Disorder
Systemic Primary Arterial Hypertension	Hbp - [High Blood Pressure]
Systemic Arterial Hypertensive Disorder	Elevated Blood Pressure
Arterial Hypertension Nos	Hypertension Nos
Benign Hypertension	Systemic Arterial Hypertension
Systemic Hypertension	Artery Htn
Benign Htn	Vascular Htn
Vascular Hypertension	Cholesterol Hypertension
Cholesterol Htn	Idiopathic Htn
Malignant Hypertension	Malignant Htn
Raised Blood Pressure	Cardiovascular Hypertension
Primary Htn - [Hypertension]	High Arterial Tension
High Blood Pressure Disorder	Ht - [Hypertension]
Htn - [Hypertension]	Hypertensive Vascular Disease
Hypertensive Vascular Degeneration

Epilepsy

Epilepsy Syndrome	Epileptic Syndrome
Epilepsies	Symptomatic Epilepsies
Post Traumatic Epilepsy	Traumatic Epilepsy
Traumatic Epileptic	Epilepsy Due To Hippocampal Sclerosis
Epilepsy With Ammon'S Horn Sclerosis	Epilepsy Due To Cortical Dysplasia
Epilepsy Due To Neuronal Migration Disorders

Myocardial Infarction

Heart Attack	Myocardial Infarction, Susceptibility To
Myocardial Infarction 1	Myocardial Infarction, Protection Against
Myocardial Infarction, Decreased Susceptibility To	Myocardial Infarction, Decreased
Myocardial Infarct	MCI1
Premature Myocardial Infarction	Myocardial Infarction, Susceptibility To, Type 1

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS00412	ADRA2B Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	ADRA2B	VGNC	VGNC:37675
Mus musculus	ADRA2B	MGD	MGI:87935
Macaca mulatta	ADRA2B	VGNC	VGNC:69724
Felis catus	ADRA2B	VGNC	VGNC:59656
Bos taurus	ADRA2B	VGNC	VGNC:25696
Rattus norvegicus	ADRA2B	RGD	RGD:2057

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。	站点地图隐私声明
沪ICP备15051369号-4 上海工商沪公网安备31011502019417 沪(浦)应急管危经许[2021]201709(QFYS) 营业执照（三证合一）
Copyright © 2013-2025 MedChemExpress. All Rights Reserved.

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

ADRA2B - adrenoceptor alpha 2B Gene

关于 ADRA2B

功能概要

ADRA2B 基因产物(1)

ADRA2B 蛋白结构

ADRA2B 蛋白互作信息

关联疾病

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

姓名
邮箱 *

Sorry, but the email address you supplied was invalid.

ADRA2B - adrenoceptor alpha 2B Gene

关于 ADRA2B

功能概要

ADRA2B 基因产物(1)

ADRA2B 蛋白结构

ADRA2B 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z