2. Gene
  3. CTSH - cathepsin H Gene

CTSH - cathepsin H Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：组织蛋白酶 H

种属: Homo sapiens

同用名: ACC4; ACC5; CPSB; ACC-4; ACC-5

基因 ID: 1512 | 基因类型: protein coding

关于 CTSH

Cytogenetic location: 15q25.1 Genomic coordinates (GRCh38): 15:78,921,058-78,945,046 (from NCBI)

This gene has 69 transcripts (splice variants), 225 orthologues, 12 paralogues and is associated with 1 phenotype. Broad expression in lung (RPKM 144.1), kidney (RPKM 97.7) and 24 other tissues.

功能概要

由该基因编码的蛋白质是溶酶体半胱氨酸蛋白酶，在溶酶体蛋白质的整体降解中很重要。它由二硫键连接的重链和轻链的二聚体组成，均由单一蛋白质前体产生。编码的蛋白质属于肽酶 C1 蛋白家族，既可以作为氨肽酶，也可以作为内肽酶。该基因表达的增加与前列腺肿瘤的恶性进展相关。该基因的交替剪接导致编码不同亚型的多个转录变体。[RefSeq 提供，2016 年 1 月]

The protein encoded by this gene is a lysosomal cysteine proteinase important in the overall degradation of lysosomal proteins. It is composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. The encoded protein, which belongs to the peptidase C1 protein family, can act both as an Aminopeptidase and as an endopeptidase. Increased expression of this gene has been correlated with malignant progression of prostate tumors. Alternate splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]

CTSH 基因产物(3)

mRNA Protein Name
NM_001319137.2 NP_001306066.1 pro-cathepsin H isoform c
NM_001411095.1 NP_001398024.1 pro-cathepsin H isoform d
NM_004390.5 NP_004381.2 pro-cathepsin H isoform a preproprotein
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables HLA-A specific activating MHC class I receptor activity IDA
IDA: 通过直接分析推断
16822283 GOA
enables aminopeptidase activity IDA
IDA: 通过直接分析推断
15127951 GOA
enables cysteine-type endopeptidase activator activity involved in apoptotic process IDA
IDA: 通过直接分析推断
20435891 GOA
enables cysteine-type endopeptidase activity IDA
IDA: 通过直接分析推断
6203523 GOA
enables cysteine-type peptidase activity IDA
IDA: 通过直接分析推断
8811434 GOA
enables endopeptidase activity IDA
IDA: 通过直接分析推断
14766755 GOA
enables peptidase activity IDA
IDA: 通过直接分析推断
18216060 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
6203523 GOA
enables thyroid hormone binding IDA
IDA: 通过直接分析推断
21217776 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in ERK1 and ERK2 cascade IDA
IDA: 通过直接分析推断
21217776 GOA
involved in adaptive immune response IEP
IEP: 通过表达模式推断
15196205 GOA
involved in bradykinin catabolic process IDA
IDA: 通过直接分析推断
15127951 GOA
involved in cellular response to thyroid hormone stimulus IEP
IEP: 通过表达模式推断
21217776 GOA
involved in immune response-regulating signaling pathway IDA
IDA: 通过直接分析推断
16822283 GOA
involved in membrane protein proteolysis IDA
IDA: 通过直接分析推断
14766755 GOA
involved in neuropeptide catabolic process IDA
IDA: 通过直接分析推断
15127951 GOA
involved in positive regulation of cell migration IDA
IDA: 通过直接分析推断
21217776 GOA
involved in positive regulation of gene expression IDA
IDA: 通过直接分析推断
21217776 GOA
involved in positive regulation of peptidase activity IDA
IDA: 通过直接分析推断
20435891 GOA
involved in protein destabilization IMP
IMP: 通过突变表型推断
17500053 GOA
involved in proteolysis IDA
IDA: 通过直接分析推断
6203523 GOA
involved in surfactant homeostasis IDA
IDA: 通过直接分析推断
18216060 GOA
involved in zymogen activation IDA
IDA: 通过直接分析推断
20435891 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in alveolar lamellar body IDA
IDA: 通过直接分析推断
18216060 GOA
located in cytosol IDA
IDA: 通过直接分析推断
9050938 GOA
located in extracellular space IDA
IDA: 通过直接分析推断
9050938 GOA
located in lysosome IDA
IDA: 通过直接分析推断
1837142 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CTSH 蛋白结构

Inhibitor_I29

Inhibitor_I29: Cathepsin propeptide inhibitor domain (I29) (35 - 89)

Peptidase_C1

Peptidase_C1: Papain family cysteine protease (117 - 332)

  • 0
  • 100
  • 200
  • 300
  • 335 a.a.
蛋白主名 其他名称

pro-cathepsin H

N-benzoylarginine-beta-naphthylamide hydrolase

CTSH 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
CTSH P09668 ATN1 Homo sapiens Q86V38
Validated Y2H
32814053
种属内
CTSH P09668 ATN1 Homo sapiens Q86V38
Y2H Array
32814053
种属内
CTSH P09668 ATN1 Homo sapiens Q86V38
Y2H Pooling
32814053
种属内
CTSH P09668 KLK6 Homo sapiens Q92876
Validated Y2H
32814053
种属内
CTSH P09668 KLK6 Homo sapiens Q92876
Y2H Pooling
32814053
种属内
CTSH P09668 KLK6 Homo sapiens Q92876
Y2H Array
32814053
种属间: 跨种属相互作用 种属内: 同种属相互作用

CTSH 抗体

目录号 产品名 应用 反应物种
HY-P82802 Cathepsin L/V/K/H Antibody (YA2547) WB, IHC-P, ICC/IF, FC Human, Mouse, Rat

关联疾病

疾病名称 别名
Narcolepsy 1

NRCLP1

Narcoleptic Syndrome 1

Gelineau Disease

Narcolepsy-Cataplexy

Narcolepsy-Cataplexy Syndrome

Narcolepsy, Type 1

Narcolepsy Type 1

Cataplexy

Gélineau'S Syndrome

Narcolepsy With Cataplexy And/Or Hypocretin Deficiency
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-E70227 Cathepsin G, human neutrophils 90.00% 否
HY-RS03336 CTSH Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus CTSH RGD RGD:2447
Bos taurus CTSH VGNC VGNC:27816
Canis familiaris CTSH VGNC VGNC:39713
Macaca mulatta CTSH VGNC VGNC:71558
Felis catus CTSH VGNC VGNC:61268
Mus musculus CTSH MGD MGI:107285
Others CTSH NCBI
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